The biological role of the unique molecule RCAS1: a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis

10.2741/2748 ◽  
2008 ◽  
Vol 13 (13) ◽  
pp. 1106 ◽  
Author(s):  
Kenzo Sonoda
Keyword(s):  
Connective Tissue ◽  
Tissue Remodeling ◽  
Biological Role ◽  
Lymphocyte Apoptosis ◽  
Connective Tissue Remodeling

scholarly journals Synaptic activity and connective tissue remodeling in denervated frog muscle.

1994 ◽  
Vol 127 (5) ◽  
pp. 1435-1445 ◽  
Author(s):  
E A Connor ◽  
K Qin ◽  
H Yankelev ◽  
D DeStefano
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Connective Tissue ◽  
Muscle Activity ◽  
Tissue Remodeling ◽  
Interstitial Cells ◽  
Frog Muscle ◽  
Connective Tissue Remodeling ◽  
Denervated Frog Muscle

Denervation of skeletal muscle results in dramatic remodeling of the cellular and molecular composition of the muscle connective tissue. This remodeling is concentrated in muscle near neuromuscular junctions and involves the accumulation of interstitial cells and several extracellular matrix molecules. Given the role of extracellular matrix in neurite outgrowth and synaptogenesis, we predict that this remodeling of the junctional connective tissue directly influences the regeneration of the neuromuscular junction. As one step toward understanding the role of this denervation-induced remodeling in synapse formation, we have begun to look for the signals that are involved in initiating the junctional accumulations of interstitial cells and matrix molecules. Here, the role of muscle inactivity as a signal was examined. The distributions of interstitial cells, fibronectin, and tenascin were determined in muscles inactivated by presynaptic blockade of muscle activity with tetrodotoxin. We found that blockade of muscle activity for up to 4 wk produced neither the junctional accumulation of interstitial cells nor the junctional concentrations of tenascin and fibronectin normally present in denervated frog muscle. In contrast, the muscle inactivity induced the extrajunctional appearance of two synapse-specific molecules, the acetylcholine receptor and a muscle fiber antigen, mAb 3B6. These results demonstrate that the remodeling of the junctional connective tissue in response to nerve injury is a unique response of muscle to denervation in that it is initiated by a mechanism that is independent of muscle activity. Thus connective tissue remodeling in denervated skeletal muscle may be induced by signals released from or associated with the nerve other than the evoked release of neurotransmitter.

scholarly journals Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1

2001 ◽  
Vol 116 (3) ◽  
pp. 417-425 ◽  
Author(s):  
Xu Shi-wen ◽  
Christopher P. Denton ◽  
Alan M. Holmes ◽  
Carol M. Black ◽  
David J. Abraham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Connective Tissue ◽  
Tissue Remodeling ◽  
Endothelin 1 ◽  
Matrix Gene ◽  
Connective Tissue Remodeling

Markers of connective tissue remodeling in genital prolapse

GYNECOLOGY ◽  
2016 ◽  
Vol 18 (3) ◽  
Author(s):  
M.L Khanzadyan ◽  
V.E. Radzinskiy ◽  
T.A. Demura ◽  
A.V. Donnikov
Keyword(s):  
Connective Tissue ◽  
Tissue Remodeling ◽  
Genital Prolapse ◽  
Connective Tissue Remodeling

scholarly journals Morphological features and the functional state of connective tissue of the uterine rudiments in reproductive age patients with Mayer–Rokitansky–Küster–Hauser syndrome

2020 ◽  
Vol 9 (4) ◽  
pp. 24-30
Author(s):  
A.V. Asaturova ◽  
◽  
N.M. Faizullina ◽  
M.V. Bobkova ◽  
A.S. Arakelyan ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Collagen Type ◽  
Tissue Remodeling ◽  
Collagen Type I ◽  
Morphological Features ◽  
Control Group ◽  
Type I ◽  
Variable Degree ◽  
Collagen Iii ◽  
Connective Tissue Remodeling

Introduction. Female patients with Mayer–Rokitansky–Küster–Hauser syndrome (MRKH) have high stigma scores; the condition severely affects the reproductive system. The study aimed at specification of morphological features and assessment of the maturity of connective tissues of the uterine rudiments in MRKH. Patients and methods. The study included 42 patients with vaginal and uterine aplasia having functioning uterine rudiments and 47 patients of the control group without genital malformations. Age of the patients was 20-24 years in 67.2% of the cases, and 31.2% of the patients were aged ≤ 19, inclusive. Immunohistochemi-cal assay was applied to determine expression levels of collagen I, collagen III, ММР2, ММР9, TIMP1, fibronectin and laminin proteins within the functioning uterine rudiments in comparison with levels of the same proteins in normally developed uterine tissues. Results. Decreased expression of collagen type I and elevated levels of MMP2 and MMP9 proteins in uterine tissues were observed for the group of patients with MRKH. Conclusions. 1) Uterine rudiments in patients with MRKH show variable degree of morphological similarity with the normally developed uterus; 2) The functioning uterine rudiments are subject to the same pathological processes as the normally developed uterus (myoma, endometriosis). 3) The functioning uterine rudiments in patients with MRKH show altered patterns of connective tissue remodeling, with decreased expression of collagen type I and increased expression of matrix metalloproteinases MMP2 and MMP9. Keywords: Müllerian aplasia, uterine rudiments, metalloproteinases, connective tissue remodeling, ММР2, ММР9

Influence of laser photobiomodulation upon connective tissue remodeling during wound healing

2008 ◽  
Vol 92 (3) ◽  
pp. 144-152 ◽  
Author(s):  
Alena P. Medrado ◽  
Ana Prates Soares ◽  
Elisângela T. Santos ◽  
Sílvia Regina A. Reis ◽  
Zilton A. Andrade
Keyword(s):  
Wound Healing ◽  
Connective Tissue ◽  
Tissue Remodeling ◽  
Connective Tissue Remodeling
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