Histopathological Changes in surgically excised mitral valves from patients with rheumatic heart disease

2020 ◽  
Vol 15 (1) ◽  
pp. 08-11
Author(s):  
M Suresh ◽  
◽  
P Suganthi ◽  
Keyword(s):  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Histopathological Changes ◽  
Mitral Valves ◽  
Rheumatic Heart

Immediate outcome following valve surgery for rheumatic heart disease: the first local experience from Ethiopia

2020 ◽  
Vol 30 (9) ◽  
pp. 1281-1287
Author(s):  
Fekede A. Debel ◽  
Belete Zekarias ◽  
Tomasa Centella ◽  
Atnafu M. Tekleab
Keyword(s):  
Heart Disease ◽  
Mitral Valve ◽  
Rheumatic Heart Disease ◽  
Surgical Outcome ◽  
Addis Ababa ◽  
Mitral Valve Surgery ◽  
Valve Surgery ◽  
Mitral Valves ◽  
Excellent Outcome ◽  
Rheumatic Heart

AbstractBackground:Rheumatic heart disease is the most common cardiac diseases in developing countries including Ethiopia. The current study aimed to describe the immediate surgical outcome following valve surgery for rheumatic heart disease in Ethiopia.Methods:Data were collected through chart abstraction from two centres in Addis Ababa, Ethiopia: the Cardiac Center of Ethiopia and El Ouzier cardiac centre. Included were all patients who were operated for rheumatic valvular heart disease in the mentioned centres by local cardiac surgical team during the period from June 2017 to April 2020. Demographic and clinical characteristics of the study population at admission and within 30 days of the index cardiac surgery were collected. Statistical Package for Social Sciences version 20.0 for windows was used to analyse the data.Result:Of the 114 patients included in the study (median age 31 years with interquartile range of 23–40), 62 (54.4%) of them were female. Surgical procedures done were triple valve surgery 9 (7.9%) patients, mitral and tricuspid valves 26 (22.8%) patients, double-valve 16 (14.0%) patients, single-valve surgery 50.9% (11 aortic and 47 mitral valves) of patients, redo mitral valve surgery 3 (2.6%) patients, and left maze with mitral valve surgery 2 (1.8%) patients. Of the total, 103 (90.4%) of them had mitral valve surgery. Post-operatively, 5 (4.4%) patients died within 30 days following the index surgery.Conclusion:Immediate surgical outcome following valve surgery for rheumatic heart disease had excellent outcome in our setting. This evidence can be taken as a show of success in building local capacity to manage rheumatic heart disease surgically.

scholarly journals Circulating level and tissue distribution of sclerostin in calcified mitral valves of rheumatic heart disease

2017 ◽  
Vol 69 ◽  
pp. S4
Author(s):  
S. Mukhopadhyay ◽  
A. Bhauwala ◽  
R.K. Saran ◽  
J. Yusuf ◽  
M. Subberwal ◽  
...  
Keyword(s):  
Heart Disease ◽  
Tissue Distribution ◽  
Rheumatic Heart Disease ◽  
Mitral Valves ◽  
Rheumatic Heart

scholarly journals Treating Children With Advanced Rheumatic Heart Disease in Sub-Saharan Africa: The NGO EMERGENCY's Project at the Salam Centre for Cardiac Surgery in Sudan

2021 ◽  
Vol 9 ◽  
Author(s):  
Rossella Miccio ◽  
Maria Quattrociocchi ◽  
Lorenzo Valgoi ◽  
Liliane Chatenoud ◽  
Salvatore Lentini ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Open Heart Surgery ◽  
Sub Saharan Africa ◽  
Mitral Valves ◽  
Operative Care ◽  
Sub Saharan ◽  
Rheumatic Heart

Rheumatic heart disease is endemic in Sub-Saharan Africa and while efforts are under way to boost prophylaxis and early diagnosis, access to cardiac surgery is rarely affordable. In this article, we report on a humanitarian project by the NGO EMERGENCY, to build and run the Salam Centre for Cardiac Surgery in Sudan. This hospital is a center of excellence offering free-of-charge, high-quality treatment to patients needing open-heart surgery for advanced rheumatic and congenital heart disease. Since it opened in 2007, more than 8,000 patients have undergone surgery there; most of them Sudanese, but ~20% were admitted from other countries, an example of inter-African cooperation. The program is not limited to surgical procedures. It guarantees long-term follow-up and anticoagulant treatment, where necessary. By way of example, we report clinical features and outcome data for the pediatric cohort: 1,318 children under the age of 15, operated on for advanced rheumatic heart disease between 2007 and 2019. The overall 5-year survival rate was 85.0% (95% CI 82.7–87.3). The outcomes for patients with mitral valves repaired and with mitral valves replaced are not statistically different. Nevertheless, observing the trend of patients undergoing valve repair, a better outcome for this category might be assumed. RHD in children is an indicator of poor socio-economic conditions and an inadequate health system, which clearly will not be cured by cardiac surgery alone. Nevertheless, the results achieved by EMERGENCY, with the crucial involvement and participation of the Sudanese government over the years, show that building a hospital, introducing free cardiac surgery, and offering long-term post-operative care may help spread belief in positive change in the future.

scholarly journals Microbiota in Gut, Oral Cavity, and Mitral Valves Are Associated With Rheumatic Heart Disease

2021 ◽  
Vol 11 ◽  
Author(s):  
Xue-Rui Shi ◽  
Bo-Yan Chen ◽  
Wen-Zhen Lin ◽  
Yu-Lin Li ◽  
Yong-Li Wang ◽  
...  
Keyword(s):  
Heart Disease ◽  
Oral Cavity ◽  
Rheumatic Heart Disease ◽  
Heart Valves ◽  
16S Rrna Gene Sequencing ◽  
Autoimmune Response ◽  
Rrna Gene ◽  
Mitral Valves ◽  
Control Subjects ◽  
Rheumatic Heart

Rheumatic heart disease refers to the long-term damage of heart valves and results from an autoimmune response to group A Streptococcus infection. This study aimed to analyze the microbiota composition of patients with rheumatic heart disease and explore potential function of microbiota in this disease. First, we revealed significant alterations of microbiota in feces, subgingival plaques, and saliva of the patients compared to control subjects using 16S rRNA gene sequencing. Significantly different microbial diversity was observed in all three types of samples between the patients and control subjects. In the gut, the patients possessed higher levels of genera including Bifidobacterium and Eubacterium, and lower levels of genera including Lachnospira, Bacteroides, and Faecalibacterium. Coprococcus was identified as a super-generalist in fecal samples of the patients. Significant alterations were also observed in microbiota of subgingival plaques and saliva of the patients compared to control subjects. Second, we analyzed microbiota in mitral valves of the patients and identified microbes that could potentially transmit from the gut or oral cavity to heart valves, including Streptococcus. Third, we further analyzed the data using random forest model and demonstrated that microbiota in the gut, subgingival plaque or saliva could distinguish the patients from control subjects. Finally, we identified gut/oral microbes that significantly correlated with clinical indices of rheumatic heart disease. In conclusion, patients with rheumatic heart disease manifested important alterations in microbiota that might distinguish the patients from control subjects and correlated with severity of this disease.

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