Rheumatic heart disease hits developing countries hardest

2014 ◽  
Author(s):  
Biplab Das
Keyword(s):  
Developing Countries ◽  
Heart Disease ◽  
Rheumatic Heart Disease ◽  
Rheumatic Heart

scholarly journals Standard echocardiography versus handheld echocardiography for the detection of subclinical rheumatic heart disease: protocol for a systematic review

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e020140 ◽  
Author(s):  
Lisa H Telford ◽  
Leila H Abdullahi ◽  
Eleanor A Ochodo ◽  
Liesl J Zühlke ◽  
Mark E Engel
Keyword(s):  
Systematic Review ◽  
Developing Countries ◽  
Heart Disease ◽  
Diagnostic Accuracy ◽  
Rheumatic Heart Disease ◽  
Sensitivity And Specificity ◽  
Meta Analysis ◽  
High Specificity ◽  
Asymptomatic Patients ◽  
Rheumatic Heart

IntroductionRheumatic heart disease (RHD) is a preventable and treatable chronic condition which persists in many developing countries largely affecting impoverished populations. Handheld echocardiography presents an opportunity to address the need for more cost-effective methods of diagnosing RHD in developing countries, where the disease continues to carry high rates of morbidity and mortality. Preliminary studies have demonstrated moderate sensitivity as well as high specificity and diagnostic odds for detecting RHD in asymptomatic patients. We describe a protocol for a systematic review on the diagnostic performance of handheld echocardiography compared to standard echocardiography using the 2012 World Heart Federation criteria for diagnosing subclinical RHD.Methods and analysisElectronic databases including PubMed, Scopus, Web of Science and EBSCOhost as well as reference lists and citations of relevant articles will be searched from 2012 to date using a predefined strategy incorporating a combination of Medical Subject Heading terms and keywords. The methodological validity and quality of studies deemed eligible for inclusion will be assessed against review specific Quality Assessment of Diagnostic Accuracy Studies 2 criteria and information on metrics of diagnostic accuracy and demographics extracted. Forest plots of sensitivity and specificity as well as scatter plots in receiver operating characteristic (ROC) space will be used to investigate heterogeneity. If possible, a meta-analysis will be conducted to produce summary results of sensitivity and specificity using the Hierarchical Summary ROC method. In addition, a sensitivity analysis will be conducted to investigate the effect of studies with a high risk of bias.Ethics and disseminationEthics approval is not required for this systematic review of previously published literature. The planned review will provide a summary of the diagnostic accuracy of handheld echocardiography. Results may feed into evidence-based guidelines and should the findings of this review warrant a change in clinical practice, a summary report will be disseminated among leading clinicians and healthcare professionals in the field.PROSPERO registration numberCRD42016051261.

scholarly journals INFECTIVE ENDOCARDITIS DUE T O SALMONELLA TYPHI

1970 ◽  
Vol 43 (156) ◽  
Author(s):  
Basudha Khanal ◽  
S K Sharma ◽  
M Deb
Keyword(s):  
Developing Countries ◽  
Heart Disease ◽  
Infective Endocarditis ◽  
Rheumatic Heart Disease ◽  
Salmonella Typhi ◽  
Clinical Criteria ◽  
Rheumatic Heart

Rheumatic Heart Disease (RHD) remains an important predisposing lesion for infective endocarditis (IE)in developing countries. IE due to Salmonella typhi is rare but associated with potentially morbidcomplications.We report a case of Salmonella typhi in a patient with rheumatic heart disease. The diagnosisof IE was confirmed on the basis of Duke’s clinical criteria. She responded to ciprofloxacin and gentamicin.Key Words: Rheumatic Heart Disease, Infective endocarditis, Salmonella typhi.

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