Association between mean platelet volume with risk factors of myocardial infarction

2020 ◽  
Vol 14 (2) ◽  
pp. 59-64
Author(s):  
Ranjith K ◽  
◽  
Ganesh Jadhao ◽  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Platelet Volume

Mean Platelet Volume (MPV) Analysis In Patients with Coronary Arterial Disease

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3172-3172
Author(s):  
Bianca Rodrigues ◽  
Hudson Hubner França ◽  
Jose R Maiello ◽  
Soraia Romanini ◽  
Fernanda Pasuld ◽  
...  
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Disease ◽  
Mean Platelet Volume ◽  
Female Group ◽  
Platelet Volume ◽  
Coronary Arterial Disease ◽  
Coronary Diseases ◽  
History Of ◽  
The Mean

Abstract Abstract 3172 Platelets have a predominant role in the pathogenesis of Acute Coronary Syndromes (ACS). It is believed that the mean platelet size, evaluated by the mean platelet volume (MPV), is a sensitive indicator of platelet reactivity and thrombogenicity potential. Many studies found association between the MPV and the ACS or the occurrence of Acute Myocardial Infarction (AMI). The reasons for this are not well known, but may be due to platelet aggregation or consumption. The aim of this study was to evaluate the MPV in Coronary diseases patients and correlate it with risk factors to these diseases. The patients included were those who would be submitted to procedures like coronariography, angioplasty and myocardial bypass. They were evaluated by a hemogram with the MPV and answered to a questionary about risk factors to coronary disease. We observed that all patients (N=72) had an elevated MPV, ranging from 9.1 to 13,7 and a mean of 11,57fL. The mean age was 63,4 years, being 32% women and 68% men. The mean MPV in the female group was slightly higher than in the men group (11,95 fL vs 11,39), but not statistically significant.(p=0,09) The relation between risk factors and the MPV was as follows: High Corporeal Mass Index had a higher mean MPV (11,63 vs 11,46fl), but no statistically significance was found.(p=0,24) When asked about Hypertension, Diabetes and Dislipidemia, 88,9% confirmed at least one of these diseases, and had a mean MPV higher than those without them. (11,6vs11,3fl) (p<0,0001) When each group, with one of these diseases were compared with the group without them, we observed that the group with diabetes had a higher MPV (11,46 vs 11,30fl)(p=0,01), the same happening with the hypertension group (11,60 vs 11,30fl)(p<0,0001), and in the group of dislipidemic patients, in whom we observed the higher mean value (12,3 vs 11,30 fl)(p=0,019) We could not find differences between the MPV of smokers and no smokers (11,60 vs 11,63 fL)(p=0,9080). The history of previous Myocardial Infarction did not correlate with a higher MPV (11,56 vs 11,61fl)(p=0,41) The family history of coronary diseases did correlate with a higher mean MPV. (11,61vs11,46)(p=0,0201). At last, the use o one anti-aggregating agent was associated with a lower MPV (11,57vs11,59)(p=0,0012). It was expected that all patients had an elevated MPV, and this is observed in some publications. The explanation for these results is linked to the fact that all patients in the study had coronary arterial diseases and probably higher platelet consumption. This consumption stimulates the production of larger platelets, increasing the MPV. The risk factors are highly associated with coronary diseases and that is why they were associated with a higher mean MPV too. The MPV comes with a simple hemogram and is easily done, has no contra-indications, and with a very low cost can be used as a marker of coronary disease. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Study of the Relationship Between Mean Platelet Volume and LAD as a Culprit Vessel in NSTEMI

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Ahmad Separham ◽  
Alireza Shahsavani ◽  
Ali Heidari Sarvestani
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Complete Blood Count ◽  
St Elevation Myocardial Infarction ◽  
Platelet Volume ◽  
Good Tool ◽  
Cross Sectional ◽  
Significant Difference ◽  
St Elevation

Background: Among acute coronary patients, the ratio of non ST-elevation myocardial infarction (NSTEMI) is increasing and according to recent studies, less than 30% of myocardial infarctions (MIs) are due to ST-elevation myocardial infarction (STEMI). Unlike STEMI, in NSTEMI the ECG is not able to identify the culprit vessel. Objectives: In this study, we aimed to evaluate the association of mean platelet volume (MPV) and NSTEMI due to left anterior descending lesion. Methods: In this cross sectional study 349 patients with NSTEMI were included. Major cardiac risk factors (cigarette, diabetes mellitus (DM), hypertension (HTN), hyperlipidemia (HLP), angiographic findings, and drug history of patients were extracted from patients’ medical files. Then the MPV in complete blood count results and angiography findings were analyzed for any association. According to culprit lesions patients were divided into left anterior descending (LAD) and non-LAD groups. Results: There was a significant difference between the two groups (LAD vs. non-LAD) according to platelet count (P = 0.014), MPV (P = 0.001), HLP (0.024) and DM (0.048). Multivariate regression model has shown the MPV (OR = 0.46, 95%CI = 0.27 - 0.78) and DM (OR = 0.18, 95%CI = 0.06 - 0.54) as independent risk factors for NSTEMI due to LAD lesion. The significant positive correlation was also seen between MPV and left ventricle ejection fraction (LVEF) (r = 0.22, P = 0.006). The area under the curve (AUC) of MPV for predicting LAD culprit lesion was calculated as 69% (P < 0.0001). At cut off point of 9.15, has sensitivity and specificity of MPV for predicting LAD as culprit vessel was 100% and 30% respectively. Conclusions: In NSTEMI patients MPV might be a good tool to differentiate patients with LAD as culprit vessel.

Effect of homocysteine and mean platelet volume on jenkins modified gensini score in acute myocardial infarction

2019 ◽  
Vol 50 (2) ◽  
Author(s):  
Deddy Hermawan Susanto ◽  
Reginald Leopold Lefrandt ◽  
Agnes Lucia Panda ◽  
Janry Antonius Pangemanan ◽  
Hariyanto Wijaya ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Gensini Score ◽  
Platelet Volume

Mean platelet volume and myocardial infarction

The Lancet ◽  
1992 ◽  
Vol 339 (8799) ◽  
pp. 1000-1001 ◽  
Author(s):  
JohnF. Martin ◽  
PhilipM.W. Bath ◽  
MichaelL. Burr
Keyword(s):  
Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Platelet Volume

Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site

1985 ◽  
Vol 68 (4) ◽  
pp. 419-425 ◽  
Author(s):  
Y. T. Kishk ◽  
E. A. Trowbridge ◽  
J. F. Martin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Mean Platelet Volume ◽  
Control Group ◽  
Disease Group ◽  
Platelet Volume ◽  
Asymptomatic Group

1. Mean platelet volume and count were measured in three groups: patients with acute myocardial infarction, a control group with myocardial ischaemia but no infarction and an asymptomatic group of young males. 2. Mean platelet volume was significantly larger in the myocardial infarction group compared with the ischaemic heart disease group or the asymptomatic group. 3. Two subpopulations were present within the myocardial infarction group. One subgroup had a large mean platelet volume and low count. The other subpopulation was indistinguishable, with regard to platelet count and mean volume, from the ischaemic heart disease group. 4. Over 60% of the myocardial infarction group lay in the area of high platelet volume and low count compared with 13% of the ischaemic heart disease control group and 38% of the asymptomatic group. Acute myocardial infarction is likely to be associated with a large mean platelet volume and low count compared with the ischaemic heart disease group. There is no statistical evidence that this condition is related to smoking or size and site of infarct. 5. This evidence suggests that large mean platelet volume and low platelet count could be a major risk factor for myocardial infarction.

scholarly journals Mean platelet volume and cardiovascular outcomes in acute myocardial infarction

Heart Asia ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 16-20 ◽  
Author(s):  
Mangalachulli Pottammal Ranjith ◽  
Rajendran DivyaRaj ◽  
Dolly Mathew ◽  
Biju George ◽  
Mangalath Narayanan Krishnan
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Cardiovascular Outcomes ◽  
Platelet Volume
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