Platelet volume subpopulations in acute myocardial infarction: an investigation of their homogeneity for smoking, infarct size and site

1985 ◽  
Vol 68 (4) ◽  
pp. 419-425 ◽  
Author(s):  
Y. T. Kishk ◽  
E. A. Trowbridge ◽  
J. F. Martin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Heart Disease ◽  
Ischaemic Heart Disease ◽  
Mean Platelet Volume ◽  
Control Group ◽  
Disease Group ◽  
Platelet Volume ◽  
Asymptomatic Group

1. Mean platelet volume and count were measured in three groups: patients with acute myocardial infarction, a control group with myocardial ischaemia but no infarction and an asymptomatic group of young males. 2. Mean platelet volume was significantly larger in the myocardial infarction group compared with the ischaemic heart disease group or the asymptomatic group. 3. Two subpopulations were present within the myocardial infarction group. One subgroup had a large mean platelet volume and low count. The other subpopulation was indistinguishable, with regard to platelet count and mean volume, from the ischaemic heart disease group. 4. Over 60% of the myocardial infarction group lay in the area of high platelet volume and low count compared with 13% of the ischaemic heart disease control group and 38% of the asymptomatic group. Acute myocardial infarction is likely to be associated with a large mean platelet volume and low count compared with the ischaemic heart disease group. There is no statistical evidence that this condition is related to smoking or size and site of infarct. 5. This evidence suggests that large mean platelet volume and low platelet count could be a major risk factor for myocardial infarction.

The Platelet Volume Distribution: A Signature of the Prethrombotic State in Coronary Heart Disease?

1987 ◽  
Vol 58 (02) ◽  
pp. 714-717 ◽  
Author(s):  
E A Trowbridge ◽  
J F Martin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Heart Disease ◽  
Mean Platelet Volume ◽  
Clinical Signs ◽  
Control Group ◽  
Volume Distribution ◽  
Platelet Volume ◽  
Prethrombotic State ◽  
Artery Disease

SummaryA coronary care unit population of 175 consecutive patients was studied. A clinical diagnosis of acute myocardial infarction was made in 103 cases (MI group) while 72 had chest pain, ECG indications of myocardial ischaemia, but no other clinical signs of acute myocardial infarction (control group). Based on bivariate Gaussian statistics the MI group could be divided in two groups, with respect to the platelet parameters of count and volume. The majority (65%) had large mean platelet volume and low count, while the remainder were indistinguishable from the control group. Patients with a large mean platelet volume also had significantly different volume distributions when assessed for volume dispersion, asymmetry and convexity. It is argued that this platelet volume distribution provides a signature for the prethrombotic state in ischaemic heart disease. Identification of such a platelet signature in a patient with coronary artery disease may allow appropriate prophylactic action to be taken and reduce the risk of subsequent acute myocardial infarction.

scholarly journals Comparison of Mean Platelet Volume in Acute Myocardial Infarction vs. Normal Coronary Angiography

2016 ◽  
Vol 8 (11) ◽  
pp. 320 ◽  
Author(s):  
Alireza Rai ◽  
Mohammadreza Saidi ◽  
Nahid Salehi ◽  
Farzad Sahebjamei ◽  
Masoud Jalilian ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Coronary Angiography ◽  
University Hospital ◽  
Control Group ◽  
Platelet Volume ◽  
St Segment Elevation ◽  
Significant Difference ◽  
Normal Coronary Angiography

<p>Considering the importance of cardiovascular disease and the role that platelets have in thrombosis formation in the coronary arteries, this study was done in order to assess platelet-related indices in patients who suffered acute myocardial infarction (MI) and compare them with those who had normal coronary angiography results.In this descriptive-analytical study, 200 patients who were admitted to our university hospital due to chest pain were included. The patients were divided into five groups including ST-segment elevation MI (STEMI), non-STEMI, unstable angina (UA), stable angina (SA), and healthy subjects (as control group). Platelet-related indices including platelet count as well asmean platelet volume (MPV) was determined. For this purpose, blood samples were taken from the patients upon admission and platelet count and volume were measured within three hours of admission.There was no statistically significant difference regarding MPV between the study groups (P&gt; 0.05).</p><p>MPV did not have any role in diagnosing various types of coronary artery disease (CAD).</p>

Bleeding Time and Platelet Volume in Acute Myocardial Infarction – A 2 Year Follow-Up Study

1988 ◽  
Vol 59 (03) ◽  
pp. 353-356 ◽  
Author(s):  
S Dalby Kristensen ◽  
P C Milner ◽  
J F Martin
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Bleeding Time ◽  
Significant Negative Correlation ◽  
Control Group ◽  
Volume Distribution ◽  
Platelet Volume ◽  
Follow Up Study

SummaryThe bleeding time is shortened and the mean platelet volume is increased in the acute phase of myocardial infarction. In this follow-up study we repeated the measurement of the bleeding time, the platelet count and the platelet volume distribution in 18 patients who had suffered from a definite acute myocardial infarction two years before and in 16 control patients who had been admitted with chest pain but no definite myocardial infarction at that time. At the time of follow-up the bleeding time was significantly lengthened in the myocardial infarction group (median values = 169 s and 209 s respectively), whereas it had shortened in the control group (median values = 258 s and 228 s respectively). Comparison of the platelet volume distribution curves of the myocardial infarction patients at time of infarction and 2 years later revealed a significantly higher percentage of small platelets and significantly lower percentages of both medium-sized and large platelets at the time of infarction. These changes in the platelet volume distribution could indicate consumption of medium-sized and large platelets at the time of myocardial infarction. None of the measured variables predicted which of the patients with acute myocardial infarction would subsequently re-infarct or die. In the patients studied with definite ischaemic heart disease (n = 26) a significant negative correlation between bleeding time and mean platelet volume was found. The shortened bleeding time in myocardial infarction is related to the acute event itself or preceeds it, but is reversed two years later.

scholarly journals Platelet Count and Mean Platelet Volume at the Time of and After Acute Myocardial Infarction

2016 ◽  
Vol 23 (8) ◽  
pp. 1052-1059 ◽  
Author(s):  
Alok Ravindra Amraotkar ◽  
David Day Song ◽  
Diana Otero ◽  
Patrick James Trainor ◽  
Imtiaz Ismail ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Acute Phase ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Quiescent Phase ◽  
Significant Difference ◽  
Acute Mi ◽  
Stable Cad

Platelet count has been shown to be lower and mean platelet volume (MPV) to be higher in acute myocardial infarction (MI). However, it is not known whether these changes persist post-MI or if these measures are able to distinguish between acute thrombotic and non-thrombotic MI. Platelet count and MPV were measured in 80 subjects with acute MI (thrombotic and non-thrombotic) and stable coronary artery disease (CAD) at cardiac catheterization (acute phase) and at >3-month follow-up (quiescent phase). Subjects were stratified using stringent clinical, biochemical, histological, and angiographic criteria. Outcome measures were compared between groups by analysis of variance. Forty-seven subjects met criteria for acute MI with clearly defined thrombotic (n = 22) and non-thrombotic (n = 12) subsets. Fourteen subjects met criteria for stable CAD. No significant difference was observed in platelet count between subjects with acute MI and stable CAD at the acute or quiescent phase. MPV was higher in acute MI (9.18 ± 1.21) compared to stable CAD (8.13 ± 0.66; P = 0.003) at the acute phase but not at the quiescent phase (8.48 ± 0.58 vs 8.94 ± 1.42; P = 0.19). No difference in platelet count or MPV was detected between thrombotic and non-thrombotic subsets at acute or quiescent phases. The power to detect differences in these measures between thrombotic and non-thrombotic subsets was 58%. Higher MPV at the time of acute MI is not observed by 3 months post-MI (quiescent phase). Platelet count and MPV do not differ in subjects with thrombotic versus non-thrombotic MI. Further investigation is warranted to evaluate the utility of these measures in the diagnosis of acute MI.

scholarly journals Predictive Value of Mean Platelet Volume/Platelet Count for Prognosis in Acute Myocardial Infarction

2018 ◽  
Vol 59 (2) ◽  
pp. 286-292 ◽  
Author(s):  
Chunyang Tian ◽  
Jia Song ◽  
Dongxu He ◽  
Jiake Wu ◽  
Zhijun Sun ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Predictive Value ◽  
Mean Platelet Volume ◽  
Platelet Volume

Incremental predictive value of mean platelet volume/platelet count ratio in in-hospital stroke after acute myocardial infarction

Platelets ◽  
2016 ◽  
Vol 28 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Charles Guenancia ◽  
Olivier Hachet ◽  
Karim Stamboul ◽  
Yannick Béjot ◽  
Thibault Leclercq ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Platelet Count ◽  
Predictive Value ◽  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Count Ratio

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

Effect of homocysteine and mean platelet volume on jenkins modified gensini score in acute myocardial infarction

2019 ◽  
Vol 50 (2) ◽  
Author(s):  
Deddy Hermawan Susanto ◽  
Reginald Leopold Lefrandt ◽  
Agnes Lucia Panda ◽  
Janry Antonius Pangemanan ◽  
Hariyanto Wijaya ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Gensini Score ◽  
Platelet Volume
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