scholarly journals Toxicological stress indicators in human red blood cells : changes in glutathione and glutathione S-transferase as biological markers for electrophilic and oxidative stress

1995 ◽  
Author(s):  
C.T.A. Evelo
Transfusion ◽  
2018 ◽  
Vol 58 (12) ◽  
pp. 2978-2991 ◽  
Author(s):  
Julie A. Reisz ◽  
Travis Nemkov ◽  
Monika Dzieciatkowska ◽  
Rachel Culp-Hill ◽  
Davide Stefanoni ◽  
...  

2019 ◽  
Vol 32 (6) ◽  
pp. 1096-1102 ◽  
Author(s):  
Daniela Giustarini ◽  
Isabella Dalle-Donne ◽  
Aldo Milzani ◽  
Daniela Braconi ◽  
Annalisa Santucci ◽  
...  

1999 ◽  
Vol 6 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Iwona Cicha ◽  
Yoji Suzuki ◽  
Norihiko Tateishi ◽  
Nobuji Maeda

2014 ◽  
Vol 103 (suppl 1) ◽  
pp. S128.5-S128
Author(s):  
B Porro ◽  
S Eligini ◽  
F Veglia ◽  
A Lualdi ◽  
I Squellerio ◽  
...  

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53195-53202 ◽  
Author(s):  
Pawan Kumar Maurya ◽  
Prabhanshu Kumar ◽  
Shirisha Nagotu ◽  
Subhash Chand ◽  
Pranjal Chandra

Quercetin and myricetin help against oxidative stress in human red blood cells during aging, thereby has tremendous scope in medical diagnostics and therapeutics.


Biochimie ◽  
2013 ◽  
Vol 95 (4) ◽  
pp. 833-841 ◽  
Author(s):  
Silvana Ficarra ◽  
Francesco Misiti ◽  
Annamaria Russo ◽  
Cristiana Carelli-Alinovi ◽  
Ersilia Bellocco ◽  
...  

Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 220 ◽  
Author(s):  
Fabiana Tortora ◽  
Rosaria Notariale ◽  
Viviana Maresca ◽  
Katrina Vanessa Good ◽  
Sergio Sorbo ◽  
...  

Plant polyphenols, with broadly known antioxidant properties, represent very effective agents against environmental oxidative stressors, including mercury. This heavy metal irreversibly binds thiol groups, sequestering endogenous antioxidants, such as glutathione. Increased incidence of food-derived mercury is cause for concern, given the many severe downstream effects, ranging from kidney to cardiovascular diseases. Therefore, the possible beneficial properties of Feijoa sellowiana against mercury toxicity were tested using intact human red blood cells (RBC) incubated in the presence of HgCl2. Here, we show that phenol-rich (10–200 µg/mL) extracts from the Feijoa sellowiana fruit potently protect against mercury-induced toxicity and oxidative stress. Peel and pulp extracts are both able to counteract the oxidative stress and thiol decrease induced in RBC by mercury treatment. Nonetheless, the peel extract had a greater protective effect compared to the pulp, although to a different extent for the different markers analyzed, which is at least partially due to the greater proportion and diversity of polyphenols in the peel. Furthermore, Fejioa sellowiana extracts also prevent mercury-induced morphological changes, which are known to enhance the pro-coagulant activity of these cells. These novel findings provide biochemical bases for the pharmacological use of Fejioa sellowiana-based functional foods in preventing and combating mercury-related illnesses.


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