Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells

RSC Advances ◽  
2016 ◽  
Vol 6 (58) ◽  
pp. 53195-53202 ◽  
Author(s):  
Pawan Kumar Maurya ◽  
Prabhanshu Kumar ◽  
Shirisha Nagotu ◽  
Subhash Chand ◽  
Pranjal Chandra
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Target Detection ◽  
Blood Cells ◽  
Medical Diagnostics ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Human Red Blood Cells

Quercetin and myricetin help against oxidative stress in human red blood cells during aging, thereby has tremendous scope in medical diagnostics and therapeutics.

Detection of oxidative stress biomarkers in myricetin treated red blood cells

RSC Advances ◽  
2016 ◽  
Vol 6 (102) ◽  
pp. 100028-100034 ◽  
Author(s):  
Prabhanshu Kumar ◽  
Nidhee Chaudhary ◽  
Narendra Kumar Sharma ◽  
Pawan Kumar Maurya
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers ◽  
Membrane Enzymes ◽  
Rbc Membrane

Effect of myricetin on RBC membrane enzymes (Na+, K+-ATPase and Ca2+-ATPase) and Na+, H+exchanger.

Membrane Skeletal ProteinS-Glutathionylation in Human Red Blood Cells as Index of Oxidative Stress

2019 ◽  
Vol 32 (6) ◽  
pp. 1096-1102 ◽  
Author(s):  
Daniela Giustarini ◽  
Isabella Dalle-Donne ◽  
Aldo Milzani ◽  
Daniela Braconi ◽  
Annalisa Santucci ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Human Red Blood Cells

Rheological changes in human red blood cells under oxidative stress

1999 ◽  
Vol 6 (2) ◽  
pp. 103-110 ◽  
Author(s):  
Iwona Cicha ◽  
Yoji Suzuki ◽  
Norihiko Tateishi ◽  
Nobuji Maeda
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Human Red Blood Cells

scholarly journals Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells

Transfusion ◽  
2018 ◽  
Vol 58 (12) ◽  
pp. 2978-2991 ◽  
Author(s):  
Julie A. Reisz ◽  
Travis Nemkov ◽  
Monika Dzieciatkowska ◽  
Rachel Culp-Hill ◽  
Davide Stefanoni ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Blood Bank ◽  
Human Red Blood Cells ◽  
And Oxidative Stress

scholarly journals Phenol-Rich Feijoa sellowiana (Pineapple Guava) Extracts Protect Human Red Blood Cells from Mercury-Induced Cellular Toxicity

Antioxidants ◽  
2019 ◽  
Vol 8 (7) ◽  
pp. 220 ◽  
Author(s):  
Fabiana Tortora ◽  
Rosaria Notariale ◽  
Viviana Maresca ◽  
Katrina Vanessa Good ◽  
Sergio Sorbo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Morphological Changes ◽  
Antioxidant Properties ◽  
Human Red Blood Cells ◽  
Downstream Effects ◽  
Pineapple Guava ◽  
Endogenous Antioxidants ◽  
The Many

Plant polyphenols, with broadly known antioxidant properties, represent very effective agents against environmental oxidative stressors, including mercury. This heavy metal irreversibly binds thiol groups, sequestering endogenous antioxidants, such as glutathione. Increased incidence of food-derived mercury is cause for concern, given the many severe downstream effects, ranging from kidney to cardiovascular diseases. Therefore, the possible beneficial properties of Feijoa sellowiana against mercury toxicity were tested using intact human red blood cells (RBC) incubated in the presence of HgCl2. Here, we show that phenol-rich (10–200 µg/mL) extracts from the Feijoa sellowiana fruit potently protect against mercury-induced toxicity and oxidative stress. Peel and pulp extracts are both able to counteract the oxidative stress and thiol decrease induced in RBC by mercury treatment. Nonetheless, the peel extract had a greater protective effect compared to the pulp, although to a different extent for the different markers analyzed, which is at least partially due to the greater proportion and diversity of polyphenols in the peel. Furthermore, Fejioa sellowiana extracts also prevent mercury-induced morphological changes, which are known to enhance the pro-coagulant activity of these cells. These novel findings provide biochemical bases for the pharmacological use of Fejioa sellowiana-based functional foods in preventing and combating mercury-related illnesses.

Oxidative stress as an underlying mechanism of anticancer drugs cytotoxicity on human red blood cells' membrane

2021 ◽  
Vol 72 ◽  
pp. 105106
Author(s):  
Amal Mameri ◽  
Lamine Bournine ◽  
Lotfi Mouni ◽  
Sihem Bensalem ◽  
Mokrane Iguer-Ouada
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Anticancer Drugs ◽  
Blood Cells ◽  
Underlying Mechanism ◽  
Human Red Blood Cells

scholarly journals Reducing Compounds Roles in Oxidative Stress Relieving of Human Red Blood Cells

2021 ◽  
Author(s):  
Giuseppe Gallo
Keyword(s):  
Oxidative Stress ◽  
Uric Acid ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Reducing Power ◽  
Protective Role ◽  
Membrane Lipid ◽  
Human Red Blood Cells ◽  
Low Concentrations ◽  
Wine Polyphenols

Oxidative stress is the consequence of an imbalance between pro-oxidant and antioxidant processes. Antioxidants that counteract reactive oxygen species do not all work the same way. Both resveratrol and the more powerful 4-hydroxytyrosol are excellent reducing agents. Polyphenol treatment (red wine polyphenols, resveratrol and catechin) is associated with a significant increase in anion permeability for chloride compared with control and 2.2′-azobis-2 amidinopropan dihydrochloride affected cells. Treatment with polyphenols was associated with a significant reduction in mean ± standard error of the mean membrane lipid peroxidation compared with control and 2.2′-azobis-2 amidinopropan dihydrochloride treatment. Hemolysis data are also obtained in the previously described conditions. 4-hydroxytyrosol is shown to significantly protect red blood cells from oxidative damage by 4-hydroxynonenal. But there are paradoxical effects like uric acid and creatinine. The obtained data evidence that both creatinine and uric acid levels have influence on the ratio of both malondialdehyde/protein and 4-hydroxynonenal/protein content on red blood cell ghosts, demonstrating their possible protective role against oxidative stress at low concentrations in blood and oxidizing power at higher concentrations. Finally, polyunsaturated fatty acids do not have all this reducing power.

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