scholarly journals Economic impacts of lameness in feedlot cattle1

2017 ◽  
Vol 1 (4) ◽  
pp. 467-479 ◽  
Author(s):  
J. Davis-Unger ◽  
E. A. Pajor ◽  
K. Schwartzkopf-Genswein ◽  
S. Marti ◽  
C. Dorin ◽  
...  
Keyword(s):  
Joint Infection ◽  
Feedlot Cattle ◽  
Economic Losses ◽  
Cost Models ◽  
Foot Rot ◽  
Slaughter Weight ◽  
Net Return ◽  
Joint Infections ◽  
Final Treatment ◽  
Healthy Cattle

Abstract Lameness is an important health issue in feedlot cattle; however, there is a paucity of information regarding its economic impact. Decision tree models are excellent tools for assessing costs of disease such as the net return (net return = benefit – cost). Models were developed using expert opinion, literature and retrospective feedlot data provided by Vet-Agri Health Services (VAHS, Airdrie, Alberta, Canada) collected from 2005 to 2015 on individually treated cattle (n = 30,940) from 28 feedlots. The objective was to estimate net return of various lameness diagnoses and impacts of cattle type, season of treatment, and extreme high and low cattle prices. Cattle were diagnosed as lame according to the following categories: foot rot, foot rot in heavy cattle (BW > 363 kg at treatment), injury, lame with no visible swelling, and joint infection. Records consisted of arrival and treatment weight, cost of treatment, and cattle deaths. Records included cattle types classified as: fall calves (heifer and steer), winter calves (heifer and steer) and yearling cattle (heifer and steer). Lastly, variables ADG, days on feed (DOF), and Season (spring, summer, fall, and winter) were created. Models estimated net return using cattle slaughter prices for healthy cattle that reached a slaughter weight of 635 kg and for three possible outcomes for each diagnosis after final treatment: cattle that recovered after treatment and reached a slaughter weight of 635 kg; cattle that were removed before they reached slaughter weight; or cattle that died. Compared to undiagnosed cattle with 1.36 kg/d ADG, cattle diagnosed with foot rot and foot rot heavy cattle had the highest ADG until first treatment (1.14 and 1.57 kg/d, respectively) and differed significantly (P < 0.05) compared to cattle diagnosed with injuries (0.87 kg/d), lame with no visible swelling (0.64 kg/d), and joint infections (0.53 kg/d). Yearling steers had the most positive returns compared to all other cattle types. Cattle with lighter arrival weight had lower ADG and increased economic losses after treatment compared to heavier weighted cattle on arrival. Based on average slaughter prices over a 10-yr period for healthy cattle, return was $690. Return after final treatment for cattle with foot rot was $568, foot rot in heavy cattle was $695, and injury was $259. However, joint infections and lame with no visible swelling had negative returns of –$286 and –$701, respectively.

66 Blood MicroRNAomes Revealed Signatures of Lameness Phenotypes in Feedlot Cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 38-38
Author(s):  
Wentao Li ◽  
Eóin O’Hara ◽  
Hui-Zeng Sun ◽  
Karen S Schwartzkopf-Genswein ◽  
Leluo Guan
Keyword(s):  
Mirna Expression ◽  
Skin Diseases ◽  
Expression Patterns ◽  
Feedlot Cattle ◽  
Economic Losses ◽  
Physiological Status ◽  
Blood Samples ◽  
Healthy Cattle ◽  
Novel Biomarkers ◽  
The Relationship

Abstract Lameness is a significant health issue in Canadian feedlots resulting in substantial economic losses. However, the high frequency of misdiagnosis of lameness using traditional methods leads to ineffective treatment, suggesting a new diagnostic method is needed. Growing evidence indicates that microRNAs (miRNAs) can be used as biomarkers for identifying the animals’ physiological status and the diagnosis of certain diseases, but this approach has not been utilized in beef cattle. The objective of this study was to compare blood miRNA profiles between lame and healthy cattle to investigate the relationship between miRNA expression patterns and specific lameness phenotypes. Blood samples were collected from 156 feedlot cattle at 0, 1, 2 and 3 weeks after being diagnosed with either digital dermatitis (DD; n=62), toe tip necrosis syndrome (TTNS; n = 40), or footrot (FR; n = 40) and healthy controls (HC; n = 12) for miRNA libraries construction and sequencing. A total of 314 expressed miRNAs were identified in 89 blood samples collected at week 0 across all groups, with TTN having the largest number of expressed miRNAs (291, P < 0.01) compared to all other groups (HC=276, DD=281, FR=278). Although miRNA profiles did not differ among the lameness types, type-specific miRNAs were identified; 6 in DD, 10 in TTN, 5 in FR and 7 in HC cattle. In addition, 3, 6 and 7 DE miRNAs were detected in DD, TTNS and FR when compared with HC cattle. Most of the DE and group-specific miRNAs are related to inflammation and skin diseases. The DE miRNAs were different between week 0 and all other weeks, indicating miRNA profiles may differ over time and with disease progression and recovery. These findings provide an initial understanding of the relationship between the cattle blood miRNAome and lameness and suggest that miRNA expression holds promise in the discovery of novel biomarkers for identifying lameness.

scholarly journals Prevalence and lameness-associated risk factors in Alberta feedlot cattle

2019 ◽  
Vol 3 (2) ◽  
pp. 595-606 ◽  
Author(s):  
Jessica Davis-Unger ◽  
Karen S G Schwartzkopf-Genswein ◽  
Ed A Pajor ◽  
Steve Hendrick ◽  
Sonia Marti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Feedlot Cattle ◽  
Foot Rot ◽  
Limited Information ◽  
Data Set ◽  
Joint Infections ◽  
Related Risk ◽  
Common Diagnosis ◽  
And Gender ◽  
Associated Risk Factors

AbstractLameness in cattle is a health and welfare concern; however, limited information is available on risk factors and the relationship between lameness and common diseases like bovine respiratory disease (BRD). Therefore, the objectives of this study were to: 1) identify prevalence of lameness in feedlot cattle and related risk factors of cattle diagnosed as lame; and 2) determine associations between BRD occurrence and lameness. Feedlot cattle health records were available from 28 feedlots for 10 yr. The data set consisted of 663,838 cattle records, with 13.9% (92,156) diagnosed with a disease, including 32.3%, 46.0%, and 22.0% with lameness, BRD, and other diagnoses, respectively. Lameness was classified into four categories: foot rot (FR), joint infections (JI), lame with no visible swelling (LNVS), and injuries (INJ), with a prevalence of 74.5%, 16.1%, 6.1%, and 3.1%, respectively. Lameness was compared across cattle types (arrival date and weight) as well as age classification (calf vs. yearling), gender (steer vs. heifer), and season of placement in the feedlot (spring, summer, fall, and winter). Within the disease-diagnosed population, lameness represented 28.5% of treated fall-placed calves, 38.5% of winter-placed calves, and 40.8% of treated yearlings. Foot rot was the most common diagnosis with 74.5% of all lameness diagnoses, with winter- and fall-placed calves more likely to be diagnosed with FR compared to yearlings (OR: 1.19, 95% CI: 1.10–1.30 and OR: 1.46, 95% CI: 1.38–1.55, respectively). Joint infections were the second most common diagnosis (16.1%). Compared to yearlings, fall-placed calves had a higher odds (OR: 3.64, 95% CI: 3.12–4.24) for JI. Injuries and LNVS were the least common but again fall-placed calves had higher odds of this diagnosis compared to yearlings (OR: 2.26, 95% CI: 1.70–2.99 and OR: 9.10, 95% CI: 6.26–13.2, respectively). Gender was significantly different for JI as steers were less likely affected compared to heifers (OR: 0.687, 95% CI: 0.545–0.867), and more likely affected by LNVS (OR: 2.46, 95% CI: 1.57–3.84). Of all lameness-associated deaths, JI accounted for almost 50%. Finally, cattle diagnosed with BRD were subsequently more likely to be diagnosed with INJ, JI, or LNVS (P < 0.001 for all comparisons). In conclusion, animal type and gender were associated with type of lameness diagnoses, allowing feedlots to allocate resources to groups at highest risk and focus on early intervention strategies.

scholarly journals Nanotechnology as an Anti-Infection Strategy in Periprosthetic Joint Infections (PJI)

2021 ◽  
Vol 6 (2) ◽  
pp. 91
Author(s):  
Pier Francesco Indelli ◽  
Stefano Ghirardelli ◽  
Ferdinando Iannotti ◽  
Alessia Maria Indelli ◽  
Gennaro Pipino
Keyword(s):  
Joint Infection ◽  
Treatment Strategies ◽  
High Morbidity ◽  
Treatment Protocols ◽  
Joint Infections ◽  
Prevention And Treatment ◽  
Efficient Control ◽  
Cement Joint ◽  
Clay Nanotubes

Background: Periprosthetic joint infection (PJI) represents a devastating consequence of total joint arthroplasty (TJA) because of its high morbidity and its high impact on patient quality of life. The lack of standardized preventive and treatment strategies is a major challenge for arthroplasty surgeons. The purpose of this article was to explore the potential and future uses of nanotechnology as a tool for the prevention and treatment of PJI. Methods: Multiple review articles from the PubMed, Scopus and Google Scholar databases were reviewed in order to establish the current efficacy of nanotechnology in PJI preventive or therapeutic scenarios. Results: As a prevention tool, anti-biofilm implants equipped with nanoparticles (silver, silk fibroin, poly nanofibers, nanophase selenium) have shown promising antibacterial functionality. As a therapeutic tool, drug-loaded nanomolecules have been created and a wide variety of carrier materials (chitosan, titanium, calcium phosphate) have shown precise drug targeting and efficient control of drug release. Other nanotechnology-based antibiotic carriers (lipid nanoparticles, silica, clay nanotubes), when added to common bone cements, enhanced prolonged drug delivery, making this technology promising for the creation of antibiotic-added cement joint spacers. Conclusion: Although still in its infancy, nanotechnology has the potential to revolutionize prevention and treatment protocols of PJI. Nevertheless, extensive basic science and clinical research will be needed to investigate the potential toxicities of nanoparticles.

scholarly journals Bone and Joint Infections among Hematopoietic Stem Cell Transplant Recipients

2019 ◽  
Vol 4 (5) ◽  
pp. 209-215
Author(s):  
Cybele Lara Abad ◽  
Vania Phuoc ◽  
Prashant Kapoor ◽  
Pritish K. Tosh ◽  
Irene G. Sia ◽  
...  
Keyword(s):  
Stem Cell ◽  
Septic Arthritis ◽  
Hematopoietic Stem Cell ◽  
Joint Infection ◽  
Cell Transplant ◽  
Hematopoietic Stem ◽  
Joint Infections ◽  
Bone And Joint Infections ◽  
Prosthetic Joint ◽  
Increased Risk

Abstract. Background: Hematopoietic stem cell transplantation (HSCT) recipients are at increased risk for infection. This study describes bone and joint infections (BJI) among HSCT recipients.Methods: We reviewed 5861 patients who underwent HSCT at Mayo Clinic, Rochester, MN from January 1, 2005 through January 1, 2015 for study inclusion. BJI was defined as native septic arthritis, prosthetic joint infection, osteomyelitis, and orthopedic implant infection. All adults with BJI after HSCT were included in the analysis.Results: Of 5861 patients, 33 (0.6%) developed BJI. Native joint septic arthritis was the most common BJI occurring in 15/33 (45.4%) patients. Patients were predominantly male (24/33, 72.7%), with median age of 58 (range 20-72) years. BJI was diagnosed a median of 39 (range 1-114) months after allogeneic (14/33, 42.4%) or autologous (19/33, 57.6%) HSCT. Organisms were recovered via tissue (24/27, 88.9%), synovial fluid (13/17, 76.5%), and/or blood cultures (16/25, 64%). Most underwent surgical debridement (23/33, 69.7%). Patients were followed a median of 78.3 months (range 74-119). Therapy was unsuccessful in 4/33 (12.1%), with death related to the underlying BJI in two (50%). Failure occurred a median of 3.4 (0.1-48.5) months from diagnosis. At last follow up, 7/33 (21.2%) patients were alive. Median overall survival was 13 months (0.07-70.6).Conclusion: BJI among HSCT recipients is infrequent. The most common infection is native joint septic arthritis. Pathogens appear similar to patients without HSCT. Treatment involving surgical-medical modalities is successful, with most patients surviving >1 year after BJI.

Outcomes of single- and two-stage revision total knee arthroplasty for chronic periprosthetic joint infection

2021 ◽  
Vol 103-B (8) ◽  
pp. 1373-1379
Author(s):  
Hosam E. Matar ◽  
Benjamin V. Bloch ◽  
Susan E. Snape ◽  
Peter J. James
Keyword(s):  
Total Knee Arthroplasty ◽  
Knee Arthroplasty ◽  
Joint Infection ◽  
Recurrent Infection ◽  
Primary Outcome Measure ◽  
Revision Total Knee Arthroplasty ◽  
Single Stage ◽  
Two Stage ◽  
Joint Infections ◽  
Total Knee

Aims Single-stage revision total knee arthroplasty (rTKA) is gaining popularity in treating chronic periprosthetic joint infections (PJIs). We have introduced this approach to our clinical practice and sought to evaluate rates of reinfection and re-revision, along with predictors of failure of both single- and two-stage rTKA for chronic PJI. Methods A retrospective comparative cohort study of all rTKAs for chronic PJI between 1 April 2003 and 31 December 2018 was undertaken using prospective databases. Patients with acute infections were excluded; rTKAs were classified as single-stage, stage 1, or stage 2 of two-stage revision. The primary outcome measure was failure to eradicate or recurrent infection. Variables evaluated for failure by regression analysis included age, BMI, American Society of Anesthesiologists grade, infecting organisms, and the presence of a sinus. Patient survivorship was also compared between the groups. Results A total of 292 consecutive first-time rTKAs for chronic PJI were included: 82 single-stage (28.1%); and 210 two-stage (71.9%) revisions. The mean age was 71 years (27 to 90), with 165 females (57.4%), and a mean BMI of 30.9 kg/m2 (20 to 53). Significantly more patients with a known infecting organism were in the single-stage group (93.9% vs 80.47%; p = 0.004). The infecting organism was identified preoperatively in 246 cases (84.2%). At a mean follow-up of 6.3 years (2.0 to 17.6), the failure rate was 6.1% in the single-stage, and 12% in the two-stage groups. All failures occurred within four years of treatment. The presence of a sinus was an independent risk factor for failure (odds ratio (OR) 4.97; 95% confidence interval (CI) 1.593 to 15.505; p = 0.006), as well as age > 80 years (OR 5.962; 95% CI 1.156 to 30.73; p = 0.033). The ten-year patient survivorship rate was 72% in the single-stage group compared with 70.5% in the two-stage group. This difference was not significant (p = 0.517). Conclusion Single-stage rTKA is an effective strategy with a high success rate comparable to two-stage approach in appropriately selected patients. Cite this article: Bone Joint J 2021;103-B(8):1373–1379.

scholarly journals Economic losses due to bovine mastitis in Dutch dairy herds.

1990 ◽  
Vol 38 (1) ◽  
pp. 89-92
Author(s):  
M.H.W. Schakenraad ◽  
A.A. Dijkhuizen
Keyword(s):  
Economic Impact ◽  
Bovine Mastitis ◽  
Economic Losses ◽  
Dairy Herds ◽  
Streptococcal Infections ◽  
Net Return ◽  
Fat Yield

Current annual losses due to mastitis in Dutch dairy herds were calculated to av. Dfl 136/cow per yr, which equals approx. 12% of net return on labour and management per cow on a typical farm. Reduction in milk and fat yield accounts for 70% of these losses. Streptococcal infections were found to have the highest economic impact, causing almost 40% of total losses. (Abstract retrieved from CAB Abstracts by CABI’s permission)

scholarly journals Evaluation of the standard procedure for the treatment of periprosthetic joint infections (PJI) in Germany - Results of a survey within the EndoCert initiative

2020 ◽  
Author(s):  
Christina Rimke ◽  
Andreas Enz ◽  
Hermann Josef Bail ◽  
Peter Heppt ◽  
Bernd Kladny ◽  
...  
Keyword(s):  
Treatment Guidelines ◽  
Standard Procedure ◽  
Joint Infection ◽  
Treatment Options ◽  
Two Stage ◽  
Joint Replacements ◽  
Joint Infections ◽  
Standardized Treatment ◽  
Principles Of Treatment ◽  
Further Development

Abstract Background: The periprosthetic joint infection (PJI) is a severe complication in the field of arthroplasty. Despite the rising number of primary joint replacements, no unified therapeutic standard has been established for the treatment of PJI yet.Methods: A survey on the principles of treatment of PJI in Germany wasconducted. A total of 515 EndoProthetikZentren (EPZ) were included, resulting in a response rate of 100%.Results: For early infections 97.6% of the centers use prosthesis-preserving procedures (DAIR). A one-stage exchange was implemented by less than 50% of the centers. If implemented, this treatment entails a prior selection of patients for a successful treatment. The two-stage exchange is performed in all centers, and most centers proceed with the implantation of a cemented spacer between stages. 75% of the centers proceed with a center-based concept for the treatment of PJI.Conclusion: The aim of a uniform PJI standard at the centers has not yet been fully achieved. Further improvements within the certification were initiated. The most relevant treatment options in Germany are displayed. The two-stage revision with a cemented spacer is the most widely implemented treatment. This exposition of principles could help for the further development of standardized treatment guidelines and definitions.

144 The Epidemiology of Hoof-related Lameness in Western Canadian Feedlot Cattle

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 81-82
Author(s):  
Sarah E Erickson ◽  
Murray Jelinski ◽  
Karen S Schwartzkopf-Genswein ◽  
Calvin Booker ◽  
Eugene Janzen
Keyword(s):  
North Carolina ◽  
Total Population ◽  
Health Management ◽  
Statistical Significance ◽  
Feedlot Cattle ◽  
Foot Rot ◽  
Digital Dermatitis ◽  
Multivariate Statistical ◽  
Multivariate Statistical Model ◽  
Control And Prevention

Abstract The epidemiology of hoof-related lameness (HRL) in western Canadian feedlots, with a focus on digital dermatitis (DD), was described and analyzed to help inform recommendations on lameness control and prevention in western Canadian feedlot cattle. The retrospective data in this study were accessed from 28 western Canadian feedlots that placed cattle in 2014–2018, inclusive. The total population for this study was 1,796,176 cattle, with an annual placement average of 12,830 cattle per feedlot. These data were accessed through iFHMS Consolidated Database, provided by Feedlot Health Management Services by TELUS Agriculture, and manipulated using Microsoft® Office Access 365 ProPlus and Microsoft® Office Excel 365 ProPlus. Epidemiological analyses determined that lameness accounts for 25.7% of all treatments in western Canadian feedlots. Of those treatments, 71.7% are localized to the hoof, corresponding to 18.6% of all treatments. The most common HRL diseases are infectious bovine pododermatitis [foot rot (FR)]; digital dermatitis (DD), also known as hairy-heel wart or strawberry foot rot; and toe-tip necrosis syndrome (TTNS). These diseases account for 89.6%, 7.9% and 2.4% of HRL, respectively. Between 2014 and 2018, HRL prevalence ranged between 1.93% and 3.09% of the population, with FR consistently having the highest prevalence and TTNS the lowest. HRL and DD were tested for their associations with several animal-level risk factors using © Ausvet 2021 Epitools software. The resultant crude, univariate odds ratio values, evaluated at 95% confidence, are summarized in Table 1. Based on this analysis, acquisition source has the largest influence on the odds of developing HRL and DD, followed by population size, and placement quarter. Using SAS® (Version 9.4, SAS Institute Inc, Cary, North Carolina) statistical software, these preliminary findings will be subjected to a multivariate statistical model, which will provide adjusted OR values and statistical significance for the data in this study.

Should all patients with a culture-negative periprosthetic joint infection be treated with antibiotics?

2022 ◽  
Vol 104-B (1) ◽  
pp. 183-188
Author(s):  
Maxime van Sloten ◽  
Joan Gómez-Junyent ◽  
Tristan Ferry ◽  
Nicolò Rossi ◽  
Sabine Petersdorf ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Joint Infection ◽  
Recurrent Infection ◽  
Molecular Techniques ◽  
Secondary Outcome ◽  
International Consensus ◽  
Joint Infections ◽  
Causative Microorganism ◽  
Culture Negative

Aims The aim of this study was to analyze the prevalence of culture-negative periprosthetic joint infections (PJIs) when adequate methods of culture are used, and to evaluate the outcome in patients who were treated with antibiotics for a culture-negative PJI compared with those in whom antibiotics were withheld. Methods A multicentre observational study was undertaken: 1,553 acute and 1,556 chronic PJIs, diagnosed between 2013 and 2018, were retrospectively analyzed. Culture-negative PJIs were diagnosed according to the Muskuloskeletal Infection Society (MSIS), International Consensus Meeting (ICM), and European Bone and Joint Society (EBJIS) definitions. The primary outcome was recurrent infection, and the secondary outcome was removal of the prosthetic components for any indication, both during a follow-up period of two years. Results None of the acute PJIs and 70 of the chronic PJIs (4.7%) were culture-negative; a total of 36 culture-negative PJIs (51%) were treated with antibiotics, particularly those with histological signs of infection. After two years of follow-up, no recurrent infections occurred in patients in whom antibiotics were withheld. The requirement for removal of the components for any indication during follow-up was not significantly different in those who received antibiotics compared with those in whom antibiotics were withheld (7.1% vs 2.9%; p = 0.431). Conclusion When adequate methods of culture are used, the incidence of culture-negative PJIs is low. In patients with culture-negative PJI, antibiotic treatment can probably be withheld if there are no histological signs of infection. In all other patients, diagnostic efforts should be made to identify the causative microorganism by means of serology or molecular techniques. Cite this article: Bone Joint J 2022;104-B(1):183–188.

scholarly journals Do Prosthetic Joint Infections Worsen the Functional Ambulatory Outcome of Patients with Joint Replacements? A Retrospective Matched Cohort Study

Antibiotics ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 872
Author(s):  
Isabel Mur ◽  
Marcos Jordán ◽  
Alba Rivera ◽  
Virginia Pomar ◽  
José Carlos González ◽  
...  
Keyword(s):  
Cohort Study ◽  
Joint Infection ◽  
Assistive Device ◽  
Matched Cohort ◽  
Knee Prostheses ◽  
Matched Cohort Study ◽  
Joint Infections ◽  
Prosthetic Joint ◽  
Prosthetic Joint Infections ◽  
Hip Arthroplasties

Objectives: To assess the effect on the functional ambulatory outcome of postoperative joint infection (PJI) cured at the first treatment attempt versus not developing PJI in patients with hip and knee prostheses. Methods: In a single-hospital retrospectively matched cohort study, each patient with PJI between 2007 and 2016 was matched on age, sex, type of prosthesis and year of implantation with two other patients with uninfected arthroplasties. The definition of a PJI cure included infection eradication, no further surgical procedures, no PJI-related mortality and no suppressive antibiotics. Functional ambulatory status evaluated one year after the last surgery was classified into four simple categories: able to walk without assistance, able to walk with one crutch, able to walk with two crutches, and unable to walk. Patients with total hip arthroplasties (THAs), total knee arthroplasties (TKAs) and partial hip arthroplasties (PHAs) were analysed separately. Results: A total of 109 PJI patients (38 TKA, 41 THA, 30 PHA) and 218 non-PJI patients were included. In a model adjusted for clinically relevant variables, PJI was associated with a higher risk of needing an assistive device for ambulation (vs. walking without aid) among THA (adjusted odds ratio (OR) 3.10, 95% confidence interval (95% CI) 1.26–7.57; p = 0.014) and TKA patients (OR 5.40, 95% CI 2.12–13.67; p < 0.001), and with requiring two crutches to walk or being unable to walk (vs. walking unaided or with one crutch) among PHA patients (OR 3.05, 95% CI 1.01–9.20; p = 0.047). Conclusions: Ambulatory outcome in patients with hip and knee prostheses with postoperative PJI is worse than in patients who do not have PJI.

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