309 Evaluation of a QTL for porcine circovirus type 2b (PCV2) viral load on growth performance in inoculated and vaccinated pigs for PCV2

2016 ◽  
Vol 94 (suppl_2) ◽  
pp. 145-145
Author(s):  
D. M. van Sambeek ◽  
E. R. Tosky ◽  
P. S. Miller ◽  
D. C. Ciobanu ◽  
T. E. Burkey
Keyword(s):  
Viral Load ◽  
Growth Performance ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus

scholarly journals Apoptosis in lymphoid organs of pigs naturally infected by porcine circovirus type 2

2004 ◽  
Vol 85 (10) ◽  
pp. 2837-2844 ◽  
Author(s):  
Ana R. Resendes ◽  
Natàlia Majó ◽  
Joaquim Segalés ◽  
Enric Mateu ◽  
Maria Calsamiglia ◽  
...  
Keyword(s):  
Lymph Node ◽  
Viral Load ◽  
B Cell ◽  
Inguinal Lymph Node ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus ◽  
Lymphoid Tissues ◽  
Lymphoid Depletion ◽  
Superficial Inguinal Lymph Node

The objective of the present study was to evaluate the involvement of apoptosis in the development of post-weaning multisystemic wasting syndrome (PMWS) lymphoid-depletion lesions. Twenty-one pigs that were categorized into three different lesional severity stages (S1, n=5; S2, n=7; S3, n=9) and five healthy control pigs (stage S0) were used. From all pigs, samples of thymus, spleen, tonsil, ileum and superficial inguinal lymph node were processed for histological examination, in situ hybridization for porcine circovirus type 2 (PCV2) detection and cleaved caspase-3 (CCasp3) immunohistochemistry for detection of apoptotic cells. PCV2 was quantified in serum samples by using TaqMan real-time PCR. CCasp3 labelling was measured in the different morphological compartments of all lymphoid tissues, using an automated system for quantification. Differences between each tissue compartment and lesional stage were assessed, as well as the correlation between apoptosis, lesional stage and viral load. Overall, the results indicated that the more intense the lymphoid depletion, the lower the rate of apoptosis. In the thymus, the cortex was the area where differences between PMWS-affected and control animals were more evident; it was found that all PMWS-affected pigs had significantly lower rates of apoptosis than the controls. In the secondary lymphoid organs, B-cell areas presented higher rates of apoptosis; similar apoptotic rates were found in this compartment in control and S1 pigs. In S2 and S3, B-cell areas were lost and the apoptotic pattern observed was a diffusely distributed low rate of positive cells. Significantly lower rates of apoptosis between PMWS-affected pigs and the control group were already evident in S1 for the thymus, spleen, superficial inguinal lymph node and Peyer's patches, but not for the tonsils. Apoptotic rates in lymphoid tissues were correlated inversely with viral load in serum and with severity of lesions. In conclusion, the results indicate that apoptosis is not a remarkable feature in PMWS lymphoid lesion development.

The effects of sire genotype and the porcine circovirus type 2 vaccine on the growth performance of pigs from weaning to slaughter

2009 ◽  
Vol 2009 ◽  
pp. 33-33
Author(s):  
A Taylor ◽  
S Jagger ◽  
P Toplis ◽  
I Wellock ◽  
H M Miller
Keyword(s):  
Growth Rate ◽  
Body Composition ◽  
Growth Performance ◽  
Meat Quality ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus ◽  
Lean Growth ◽  
Low Levels

Crossbreeding is common practice in commercial pig production as one way to increase lean growth and improve meat quality (Visscher et al., 2000). Reducing disease is another way to help improve growth rate in pigs. Porcine circovirus type 2 (PCV2) has devastated the pig industry in recent years. PCV2 infection increases mortality and reduces growth rate as it acts as an immunosuppressant thereby making pigs more susceptible to co-infections (Kixmöller et al 2008). Keeping disease at low levels has been achieved by improving husbandry standards, biosecurity, minimising presence of other pathogens and use of antibiotics. However vaccines against PVC2 are now available. The aim of this study was to investigate the effects of sire genotype and PCV2 vaccine on growth performance and body composition of pigs.

A field evaluation of mortality rate and growth performance in pigs vaccinated against porcine circovirus type 2

2008 ◽  
Vol 232 (6) ◽  
pp. 906-912 ◽  
Author(s):  
Kyle P. Horlen ◽  
Steve S. Dritz ◽  
Jerome C. Nietfeld ◽  
Steven C. Henry ◽  
Richard A. Hesse ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Growth Performance ◽  
Field Evaluation ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Porcine Circovirus

scholarly journals Do High Levels of Maternally Derived Antibodies Interfere with the Vaccination of Piglets against Porcine Circovirus Type 2? A Literature Review and Data Analysis

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 923
Author(s):  
Barbara Poulsen Nautrup ◽  
Ilse Van Vlaenderen ◽  
Choewkong Mah ◽  
Jose Angulo
Keyword(s):  
Viral Load ◽  
Literature Search ◽  
Field Studies ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Daily Weight Gain ◽  
Porcine Circovirus ◽  
Inclusion Criteria ◽  
Production Parameters

Vaccination against porcine circovirus type 2 (PCV2) is commonly performed in piglets worldwide, and increasingly also in sows. We conducted a literature search and review to assess the potential interference of maternally derived antibodies (MDA) in piglets with vaccination against PCV2. The effectiveness of vaccination was compared to no vaccination in the presence of high levels of MDA (≥8 log2 IPMA titer), as reported in field studies. In total, 13 papers fulfilled the predefined inclusion criteria, allowing up to 24 comparisons per parameter. In the presence of high levels of MDA, vaccinated pigs had, on average, a 20 g/d higher mean daily weight gain and a 34% lower mortality compared to non-vaccinates. The maximum percentage of viremic pigs was reduced by 63% and the maximum viral load in serum was 0.72 log10 PCV2 DNA copies lower. Vaccination at 3 weeks of age was associated with the highest improvements in production parameters and reductions in viremia. Our findings suggest that the vaccination of piglets is effective with respect to production parameters and viremia even in the presence of high MDA, with an age of 3 weeks at vaccination being most beneficial.

scholarly journals Classifying Host Susceptibility Using Porcine Circovirus Type 2 Viral Load and Antibody Titer

2017 ◽  
Vol 27 (3) ◽  
pp. 283-288
Author(s):  
Kyu-Sang Lim ◽  
Eun-A Lee ◽  
Kyung-Tai Lee ◽  
Taehoon Chun ◽  
Ki-Chang Hong ◽  
...  
Keyword(s):  
Viral Load ◽  
Antibody Titer ◽  
Porcine Circovirus Type ◽  
Porcine Circovirus Type 2 ◽  
Host Susceptibility ◽  
Porcine Circovirus
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