P3048 Gene network analysis identifies rumen epithelial processes perturbed by diet and correlated with methane production and yield

2016 ◽  
Vol 94 (suppl_4) ◽  
pp. 76-77
Author(s):  
R. Xiang ◽  
J. McNally ◽  
S. J. Rowe ◽  
A. Jonker ◽  
C. Pinares-Patino ◽  
...  
Keyword(s):  
Network Analysis ◽  
Methane Production ◽  
Gene Network ◽  
Gene Network Analysis

scholarly journals Time-Varying Gene Network Analysis of Human Prefrontal Cortex Development

2020 ◽  
Vol 11 ◽  
Author(s):  
Huihui Wang ◽  
Yongqing Wu ◽  
Ruiling Fang ◽  
Jian Sa ◽  
Zhi Li ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Network Analysis ◽  
Gene Network ◽  
Time Varying ◽  
Gene Network Analysis

The Anticancer Effects of Garlic Extracts on Bladder Cancer Compared to Cisplatin: A Common Mechanism of Action via Centromere Protein M

2018 ◽  
Vol 46 (03) ◽  
pp. 689-705 ◽  
Author(s):  
Won Tae Kim ◽  
Sung-Pil Seo ◽  
Young Joon Byun ◽  
Ho-Won Kang ◽  
Yong-June Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Network Analysis ◽  
Microarray Analysis ◽  
Gene Network ◽  
Garlic Extract ◽  
Common Mechanism ◽  
Centromere Protein ◽  
Mouse Xenograft Model ◽  
Gene Network Analysis

Although garlic induces apoptosis in cancer cells, it is unclear whether the effects are similar to those of cisplatin against bladder cancer (BC). Therefore, this study investigated whether garlic extracts and cisplatin show similar activity when used to treat BC. The effect of garlic on T24 BC cell line was examined in a BALB/C-nude mouse xenograft model and compared with that of cisplatin. Tissue microarray analysis and gene network analysis were performed to identify differences in gene expression by control tumors and tumors exposed to garlic extract or cisplatin. Investigation of gene expression based on tissues from 165 BC patients and normal controls was then performed to identify common targets of garlic and cisplatin. Tumor volume and tumor weight in cisplatin (0.05[Formula: see text]mg/kg)- and garlic-treated mice were significantly smaller than those in negative control mice. However, cisplatin-treated mice also showed a significant reduction in body weight. Microarray analysis of tumor tissue identified 515 common anticancer genes in the garlic and cisplatin groups ([Formula: see text]). Gene network analysis of 252 of these genes using the Cytoscape and ClueGo software packages mapped 17 genes and 9 gene ontologies to gene networks. BC (NMIBC and MIBC) patients with low expression of centromere protein M (CENPM) showed significantly better progression-free survival than those with high expression. Garlic extract shows anticancer activity in vivo similar to that of cisplatin, with no evident of side effects. Both appear to act by targeting protein-DNA complex assembly; in particular, expression of CENPM.

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