scholarly journals Gene network analysis identifies rumen epithelial cell proliferation, differentiation and metabolic pathways perturbed by diet and correlated with methane production

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Ruidong Xiang ◽  
Jody McNally ◽  
Suzanne Rowe ◽  
Arjan Jonker ◽  
Cesar S. Pinares-Patino ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Network Analysis ◽  
Epithelial Cell ◽  
Methane Production ◽  
Metabolic Pathways ◽  
Gene Network ◽  
Epithelial Cell Proliferation ◽  
Gene Network Analysis

P3048 Gene network analysis identifies rumen epithelial processes perturbed by diet and correlated with methane production and yield

2016 ◽  
Vol 94 (suppl_4) ◽  
pp. 76-77
Author(s):  
R. Xiang ◽  
J. McNally ◽  
S. J. Rowe ◽  
A. Jonker ◽  
C. Pinares-Patino ◽  
...  
Keyword(s):  
Network Analysis ◽  
Methane Production ◽  
Gene Network ◽  
Gene Network Analysis

scholarly journals Enhanced intestinal epithelial cell proliferation in diabetic rats correlates with β-catenin accumulation

2015 ◽  
Vol 226 (3) ◽  
pp. 135-143 ◽  
Author(s):  
Tatiana Dorfman ◽  
Yulia Pollak ◽  
Rima Sohotnik ◽  
Arnold G Coran ◽  
Jacob Bejar ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Epithelial Cell ◽  
Real Time ◽  
Real Time Pcr ◽  
Intestinal Epithelial Cell ◽  
Diabetic Rats ◽  
Male Rats ◽  
Intestinal Cell ◽  
Intestinal Epithelial ◽  
Epithelial Cell Proliferation

The Wnt/β-catenin signaling cascade is implicated in the control of stem cell activity, cell proliferation, and cell survival of the gastrointestinal epithelium. Recent evidence indicates that the Wnt/β-catenin pathway is activated under diabetic conditions. The purpose of this study was to evaluate the role of Wnt/β-catenin signaling during diabetes-induced enteropathy in a rat model. Male rats were divided into three groups: control rats received injections of vehicle; diabetic rats received injections of one dose of streptozotocin (STZ); and diabetic–insulin rats received injections of STZ and were treated with insulin given subcutaneously at a dose of 1 U/kg twice daily. Rats were killed on day 7. Wnt/β-catenin-related genes and expression of proteins was determined using real-time PCR, western blotting, and immunohistochemistry. Among 13 genes identified by real-time PCR, seven genes were upregulated in diabetic rats compared with control animals including the target genes c-Myc and Tcf4. Diabetic rats also showed a significant increase in β-catenin protein compared with control animals. Treatment of diabetic rats attenuated the stimulating effect of diabetes on intestinal cell proliferation and Wnt/β-catenin signaling. In conclusion, enhanced intestinal epithelial cell proliferation in diabetic rats correlates with β-catenin accumulation.

scholarly journals Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland

2008 ◽  
Vol 8 (1) ◽  
pp. 94 ◽  
Author(s):  
Holly E Barker ◽  
Gordon K Smyth ◽  
James Wettenhall ◽  
Teresa A Ward ◽  
Mary L Bath ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mammary Gland ◽  
Epithelial Cell ◽  
Epithelial Cell Proliferation
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