Increased intestinal barrier function in the small intestine of formula-fed neonatal piglets

2012 ◽  
Vol 90 (suppl_4) ◽  
pp. 315-317 ◽  
Author(s):  
V. Huygelen ◽  
M. De Vos ◽  
S. Willemen ◽  
B. Tambuyzer ◽  
C. Casteleyn ◽  
...  
Keyword(s):  
Small Intestine ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Neonatal Piglets

scholarly journals A breakdown in communication? Understanding the effects of aging on the human small intestine epithelium

2015 ◽  
Vol 129 (7) ◽  
pp. 529-531 ◽  
Author(s):  
Neil A. Mabbott
Keyword(s):  
Small Intestine ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Human Small Intestine ◽  
Small Intestinal ◽  
Effects Of Aging ◽  
Insight Into

A new study by Man and colleagues provides further insight into the effects of aging on small intestinal barrier function in humans. Here, their findings are briefly summarised and the wider implications discussed.

scholarly journals Meishan neonatal piglets tend to have higher intestinal barrier function than crossbred neonatal piglets

animal ◽  
2021 ◽  
Vol 15 (1) ◽  
pp. 100037
Author(s):  
L. Dong ◽  
H.M. Li ◽  
S.N. Wang ◽  
T.L. Wang ◽  
L.H. Yu ◽  
...  
Keyword(s):  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Neonatal Piglets

scholarly journals Inhibitory Effects of Sodium Alginate on Hepatic Steatosis in Mice Induced by a Methionine- and Choline-deficient Diet

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 104 ◽  
Author(s):  
Shoji Kawauchi ◽  
Sayo Horibe ◽  
Naoto Sasaki ◽  
Toshihito Tanahashi ◽  
Shigeto Mizuno ◽  
...  
Keyword(s):  
Small Intestine ◽  
Sodium Alginate ◽  
Lipid Accumulation ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Fatty Degeneration ◽  
Intestinal Barrier Function ◽  
Deficient Diet ◽  
Mucus Production ◽  
Nonalcoholic Fatty Liver

Nonalcoholic steatohepatitis (NASH) progresses from nonalcoholic fatty liver disease (NAFLD); however, efficacious drugs for NASH treatment are lacking. Sodium alginate (SA), a soluble dietary fiber extracted from brown algae, could protect the small intestine from enterobacterial invasion. NASH pathogenesis has been suggested to be associated with enterobacterial invasion, so we examined the effect of SA on methionine- and choline-deficient (MCD) diet-induced steatohepatitis in mice (the most widely-used model of NASH). The mice (n = 31) were divided into three groups (mice fed with regular chow, MCD diet, and MCD diet premixed with 5% SA) for 4 and 8 weeks. The MCD diet increased lipid accumulation and inflammation in the liver, the NAFLD Activity Score and hepatic mRNA expression of tumor necrosis factor- and collagen 11, and induced macrophage infiltration. Villus shortening, disruption of zonula occludens-1 localization and depletion of mucus production were observed in the small intestine of the MCD-group mice. SA administration improved lipid accumulation and inflammation in the liver, and impaired barrier function in the small intestine. Collectively, these results suggest that SA is useful for NASH treatment because it can prevent hepatic inflammation and fatty degeneration by maintaining intestinal barrier function.

scholarly journals Neutrophils Do Not Mediate the Pathophysiological Sequelae of Cryptosporidium parvum Infection in Neonatal Piglets

2006 ◽  
Vol 74 (10) ◽  
pp. 5497-5505 ◽  
Author(s):  
Leah M. Zadrozny ◽  
Stephen H. Stauffer ◽  
Martha U. Armstrong ◽  
Samuel L. Jones ◽  
Jody L. Gookin
Keyword(s):  
Lipid Peroxidation ◽  
Cryptosporidium Parvum ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Myeloperoxidase Activity ◽  
Neonatal Piglets ◽  
Villus Atrophy ◽  
Consistent Feature

ABSTRACT Cryptosporidium parvum is a minimally invasive protozoal pathogen of intestinal epithelium that results in villus atrophy, mucosal lipid peroxidation, diarrhea, and diminished barrier function. Influx of neutrophils is a consistent feature of human and animal cryptosporidiosis, and yet their contribution to the pathological sequelae of infection has not been investigated. Accordingly, we used an established neonatal piglet model of C. parvum infection to examine the role of neutrophils in disease pathogenesis by inhibiting their recruitment and activation in vivo using a monoclonal anti-CD18 antibody. Infected piglets were treated daily with anti-CD18 or isotype control immunoglobulin G and euthanized at peak infection, at which time neutrophil infiltrates, lipid peroxidation, severity of infection, and intestinal barrier function were quantified. C. parvum infection resulted in a significant increase in mucosal neutrophil myeloperoxidase activity that was prevented by treatment of piglets with anti-CD18 antibody. Neutrophil recruitment was dependent on mucosal superoxide formation (prevented by treatment of infected piglets with superoxide dismutase). Neutrophils did not contribute to peroxynitrite formation or peroxidative injury of C. parvum-infected mucosa and had no impact on the severity of epithelial infection, villus atrophy, or diarrhea. The presence of neutrophils in C. parvum-infected mucosa was associated with enhanced barrier function that could not be attributed to mucosal elaboration of prostaglandins or stimulation of their synthesis. These studies are the first to demonstrate that neutrophilic inflammation arising in response to infection by a noninvasive epithelial pathogen results in physiologic rather than pathological effects in vivo.

Dietary squid ink polysaccharide induces goblet cells to protect small intestine from chemotherapy induced injury

2015 ◽  
Vol 6 (3) ◽  
pp. 981-986 ◽  
Author(s):  
Tao Zuo ◽  
Lu Cao ◽  
Changhu Xue ◽  
Qing-Juan Tang
Keyword(s):  
Small Intestine ◽  
Epithelial Cells ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Goblet Cells ◽  
Intestinal Barrier Function ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Gastrointestinal Mucositis ◽  
Potential Damage

Gastrointestinal mucositis induced by chemotherapy is associated with alterations of intestinal barrier function due to the potential damage induced by anti-cancer drugs on the epithelial cells.

Influence of Plant Bioactive Compounds on Intestinal Epithelial Barrier in Poultry

2020 ◽  
Vol 20 (7) ◽  
pp. 566-577 ◽  
Author(s):  
Amlan Kumar Patra
Keyword(s):  
Bioactive Compounds ◽  
Barrier Function ◽  
Molecular Mechanisms ◽  
Digestive Enzyme ◽  
Intestinal Barrier ◽  
Feed Additives ◽  
Interactive Effects ◽  
Intestinal Barrier Function ◽  
Poultry Production ◽  
Poultry Feeding

Natural plant bioactive compounds (PBC) have recently been explored as feed additives to improve productivity, health and welfare of poultry following ban or restriction of in-feed antibiotic use. Depending upon the types of PBC, they possess antimicrobial, digestive enzyme secretion stimulation, antioxidant and many pharmacological properties, which are responsible for beneficial effects in poultry production. Moreover, they may also improve the intestinal barrier function and nutrient transport. In this review, the effects of different PBC on the barrier function, permeability of intestinal epithelia and their mechanism of actions are discussed, focusing on poultry feeding. Dietary PBC may regulate intestinal barrier function through several molecular mechanisms by interacting with different metabolic cascades and cellular transcription signals, which may then modulate expressions of genes and their proteins in the tight junction (e.g., claudins, occludin and junctional adhesion molecules), adherens junction (e.g., E-cadherin), other intercellular junctional proteins (e.g., zonula occludens and catenins), and regulatory proteins (e.g., kinases). Interactive effects of PBC on immunomodulation via expressions of several cytokines, chemokines, complement components, pattern recognition receptors and their transcription factors and cellular immune system, and alteration of mucin gene expressions and goblet cell abundances in the intestine may change barrier functions. The effects of PBC are not consistent among the studies depending upon the type and dose of PBC, physiological conditions and parts of the intestine in chickens. An effective concentration in diets and specific molecular mechanisms of PBC need to be elucidated to understand intestinal barrier functionality in a better way in poultry feeding.

Sign in / Sign up

Export Citation Format

Share Document