Effects of two different dietary sources of long chain omega-3 highly unsaturated fatty acids on incorporation into the plasma, red blood cell, and skeletal muscle in horses2

2012 ◽  
Author(s):  
T. M. Hess ◽  
J. K. Rexford ◽  
D. K. Hansen ◽  
M. Harris ◽  
N. Schauermann ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acids ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Unsaturated Fatty Acids ◽  
Omega 3 ◽  
Highly Unsaturated Fatty Acids ◽  
Long Chain

scholarly journals The same rat Δ6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

2002 ◽  
Vol 364 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Sabine D'ANDREA ◽  
Hervé GUILLOU ◽  
Sophie JAN ◽  
Daniel CATHELINE ◽  
Jean-Noël THIBAULT ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Unsaturated Fatty Acids ◽  
Fatty Acid Biosynthesis ◽  
Chain Polyunsaturated Fatty Acid ◽  
Acid Biosynthesis ◽  
Highly Unsaturated Fatty Acids ◽  
Long Chain ◽  
Δ6 Desaturase

The recently cloned Δ6-desaturase is known to catalyse the first step in very-long-chain polyunsaturated fatty acid biosynthesis, i.e. the desaturation of linoleic and α-linolenic acids. The hypothesis that this enzyme could also catalyse the terminal desaturation step, i.e. the desaturation of 24-carbon highly unsaturated fatty acids, has never been elucidated. To test this hypothesis, the activity of rat Δ6-desaturase expressed in COS-7 cells was investigated. Recombinant Δ6-desaturase expression was analysed by Western blot, revealing a single band at 45kDa. The putative involvement of this enzyme in the Δ6-desaturation of C24:5n-3 to C24:6n-3 was measured by incubating transfected cells with C22:5n-3. Whereas both transfected and non-transfected COS-7 cells were able to synthesize C24:5n-3 by elongation of C22:5n-3, only cells expressing Δ6-desaturase were also able to produce C24:6n-3. In addition, Δ6-desaturation of [1-14C]C24:5n-3 was assayed invitro in homogenates from COS-7 cells expressing Δ6-desaturase or not, showing that Δ6-desaturase catalyses the conversion of C24:5n-3 to C24:6n-3. Evidence is therefore presented that the same rat Δ6-desaturase catalyses not only the conversion of C18:3n-3 to C18:4n-3, but also the conversion of C24:5n-3 to C24:6n-3. A similar mechanism in the n-6 series is strongly suggested.

scholarly journals Six‐Year Change in Red Blood Cell Omega‐3 and Trans Fatty Acids in the Framingham Heart Study

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
William S Harris ◽  
James V Pottala ◽  
Ramachandran S Vasan ◽  
Martin G Larson ◽  
Sander J Robins
Keyword(s):  
Fatty Acids ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Framingham Heart Study ◽  
Trans Fatty Acids ◽  
Omega 3 ◽  
Heart Study

scholarly journals Erythrocyte Long Chain Omega 3 Fatty Acids Are Associated with Higher Lean Mass in Postmenopausal Women Newly Diagnosed with Breast Cancer (P05-024-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Martha Belury ◽  
Rachel Cole ◽  
Rebecca Andridge ◽  
Qing Xie ◽  
Ashleigh Keiter ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Skeletal Muscle ◽  
Fatty Acids ◽  
Body Composition ◽  
Lean Mass ◽  
Cardiometabolic Health ◽  
Omega 3 ◽  
Appendicular Lean Mass ◽  
Muscle Health ◽  
Long Chain

Abstract Objectives Cancer contributes to adverse changes in body composition that may increase risk of cardiometabolic diseases. Skeletal muscle is a main driver of cardiometabolic health. We hypothesize that higher intake of long chain omega-3 polyunsaturated fatty acids (LCn3PUFAs) is associated with muscle health. This study evaluates whether LCn3PUFA exposure assessed in diet and in blood is associated with markers of muscle health in women with breast cancer. Methods This is a cross-sectional analysis evaluating LCn3PUFA exposure and markers of muscle health in women (N = 150) prior to treatment for breast cancer. Exposure to LCn3PUFAs was assessed by a diet history questionnaire (DHQ), a question specifically about supplement usage and biomarker of LCn3PUFAs in red blood cells (RBC). Body composition were measured at the same visit using dual x-ray absorptiometry. Linear regression models were used to test for associations. Results 13% (N = 19) of women reported using fish oil supplements (e.g., Supplement Users) and had significantly higher levels of RBC LCn3PUFAs than Supplement Non-users. In Supplement Non-users, there was a positive association between reported dietary exposure by DHQ and RBC LCn3PUFA levels. The n3 index (e.g., sum of RBC EPA + DHA) and DHA (22:6n3) were positively associated with appendicular lean mass/BMI. There were no significant correlations between RBC LCn3PUFAs with grip strength and or other measurements of body composition. Conclusions As a biomarker of intake, RBC LCn3PUFAs are positively associated with appendicular lean mass, a measure of skeletal muscle mass. A future study should prospectively evaluate whether higher LCn3PUFA exposure (as measured in blood) is associated with maintaining better muscle health during and following cancer treatment. Funding Sources Funding was provided by the National Cattleman's Beef Association, NIH (JKG) CA186720, Ohio Agriculture Research and Development Center and the Carol S. Kennedy Professorship.

scholarly journals Conversion efficiency of α-linolenic acid to omega-3 highly unsaturated fatty acids in aerial insectivore chicks

2017 ◽  
Vol 221 (3) ◽  
pp. jeb165373 ◽  
Author(s):  
Cornelia W. Twining ◽  
Peter Lawrence ◽  
David W. Winkler ◽  
Alexander S. Flecker ◽  
J. Thomas Brenna
Keyword(s):  
Fatty Acids ◽  
Linolenic Acid ◽  
Conversion Efficiency ◽  
Unsaturated Fatty Acids ◽  
Omega 3 ◽  
Highly Unsaturated Fatty Acids ◽  
Aerial Insectivore

THE RELATIONSHIP OF OMEGA 3 POLYUNSATURATED FATTY ACIDS IN RED BLOOD CELL MEMBRANES WITH COGNITIVE FUNCTION AND BRAIN STRUCTURE: A REVIEW FOCUSSED ON ALZHEIMER’S DISEASE

2017 ◽  
pp. 1-7
Author(s):  
C. Hooper ◽  
P. De Souto Barreto ◽  
M. Pahor ◽  
M. Weiner ◽  
B. Vellas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fatty Acids ◽  
Cognitive Function ◽  
Blood Cell ◽  
Polyunsaturated Fatty Acids ◽  
Red Blood Cell ◽  
Omega 3 ◽  
Research Attention ◽  
Pufa Supplementation

Significant research attention has focussed on the identification of nutraceutical agents for the prevention of cognitive decline as a natural means of cognitive preservation in the elderly. There is some evidence for a reduction of brain omega 3 polyunsaturated fatty acids (n-3 PUFAs) in normal aging and in Alzheimer’s disease. n-3 PUFAs exhibit anti-inflammatory and anti-amyloidogenic properties as well as being able to reduce tau phosphorylation. Many observational studies have demonstrated a link between n-3 PUFAs and cognitive aging, and some, but not all, randomized controlled trials have demonstrated a benefit of n-3 PUFA supplementation on cognition, particularly in those subjects with mild cognitive impairment. The identification of a biomarker that reflects n-3 PUFA intake over time and consequent tissue levels is required. In this narrative review we discuss the evidence associating red blood cell membrane n-3 PUFAs with cognitive function and structural brain changes associated with Alzheimer’s disease. Key words: Docosahexaenoic acid, omega 3 polyunsaturated fatty aci

Interaction of Unsaturated Fatty Acids with the Red Blood Cell Ca2+-ATPase. Studies with a Novel Photoactivatable Probe

Biochemistry ◽  
1995 ◽  
Vol 34 (11) ◽  
pp. 3802-3812 ◽  
Author(s):  
Juan P. F. C. Rossi ◽  
Jose M. Delfino ◽  
Ariel J. Caride ◽  
Horacio N. Fernandez
Keyword(s):  
Fatty Acids ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Unsaturated Fatty Acids
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