scholarly journals Ameliorative effects of high-protein diet on hepatotoxic alterations in Swiss albino mice exposed to mobile phone radiation

2021 ◽  
Vol 64 ◽  
pp. 258-264
Author(s):  
Debajyoti Bhattacharya ◽  
Prerona Biswas ◽  
Somnath Gangopadhyay ◽  
Mausumi Sikdar Bhakta
Keyword(s):  
Electromagnetic Radiation ◽  
Mobile Phone ◽  
Mobile Phones ◽  
High Protein Diet ◽  
Normal Diet ◽  
Exposed Group ◽  
High Protein ◽  
Protein Diet ◽  
Swiss Albino Mice ◽  
Mobile Phone Radiation

Objectives: Nowadays, mobile phones have become a prime necessity. At present, various advance networking connections such as 3G and 4G are available in the market to get a faster service. However, these mobile phones emit harmful electromagnetic radiations which have various ill effects on different physiological systems. The present study has been done to find out the extent of damage caused by mobile phone radiation on liver cells, and, whether high-protein diet (HPD) has any ameliorative effect on such changes. Materials and Methods: Male Swiss Albino mice were divided into four groups. Two groups of animals were exposed to mobile phone radiation at global system for mobile communications like frequencies at 1.8 GHz for 3 h continuously per day for 90 days. One of these radiation exposed groups received a normal diet (containing 5% casein) and the other exposed group received a HPD (supplemented with 20% casein). The control group animals received only a normal diet, while the animals of the remaining group received only a HPD. The serum biochemical and histological parameters of liver tissues and ladder assay of hepatic DNA were studied. Results: A significantly elevated level (P < 0.05) of aspartate aminotransferase, alanine transaminase, bilirubin and serum caspase-3 levels was observed in the group of animals exposed to electromagnetic radiation emitted from mobile phone. Histological changes were also observed in the experimental groups. Moreover, in genomic DNA ladder assay, fragmented DNA was observed in exposed group, which is a probable sign of cell apoptosis. Recovery symptoms were observed in the animals supplemented with high casein diet. Conclusion: From the present study, it may be concluded that electromagnetic radiation emitted from mobile phones has damaging effects on hepatocytes which may be ameliorated by HPD.

scholarly journals EFFECT OF HIGH PROTEIN DIET IN ACTIVITY OF ANTIOXIDANTS AND LEVEL OF INFLAMMATION ON SPRINT ATHLETE

2021 ◽  
Author(s):  
Endang Sri Wahjunia ◽  
Soetanto Hartono
Keyword(s):  
High Protein Diet ◽  
Normal Diet ◽  
High Protein ◽  
Protein Diet ◽  
Control Group ◽  
Multivariate Technique ◽  
Tnf Α ◽  
Low Carbohydrate ◽  
Photo Camera ◽  
Laboratory Examinations

This study aims to analyze the effect of a low-carbohydrate high-protein diet to increase the level of antioxidant, decrease inflammation and improve performance of athlete. The research was carried out by experimental research methods, within the design of "Randomized Control Group Pretest Posttest Design".A sample was taken from 20 people who met the inclusion and exclusion criteria from 30 teenage athletes in PASI East Java sprints. The Data were collected by measuring the sprint results by finish photo camera and laboratory examinations to determine the levels of antioxidants (SOD) and the inflammation degree (TNF α)in blood. The data were analyzed using multivariate technique (Manova) Hotelling's method (T2). Hypothesis testing using α0.05. The results and conclusions of the study stated that the normal diet had no effect on the variables of sprint running speed, SOD and TNF-α levels. While low-carbohydrate and high-protein diet can increase SOD levels of 211.44 /gHb, reduce (TNF α) at least 0.309 pg/ml, and the average increase in antioxidant activity caused by low-carbohydrate-high-protein diet is 24,989 / gHb higher than normal diet, the decrease in the degree of inflammation is 0.196 pg/ml, however, it has no effect on the speed of sprint.

scholarly journals Effect of high protein diet in activity of antioxidants and level of inflammation on sprint athlete

2021 ◽  
Vol 57 (2) ◽  
pp. 185-194
Author(s):  
Endang Sri Wahjuni ◽  
Soetanto Hartono
Keyword(s):  
High Protein Diet ◽  
Normal Diet ◽  
High Protein ◽  
Protein Diet ◽  
Control Group ◽  
Multivariate Technique ◽  
Tnf Α ◽  
Low Carbohydrate ◽  
Photo Camera ◽  
Laboratory Examinations

This study aims to analyze the effect of a low-carbohydrate high-protein diet to increase the level of antioxidant, decrease inflammation and improve performance of athlete. The research was carried out by experimental research methods, within the design of “Randomized Control Group Pretest Posttest Design”. A sample was taken from 20 people who met the inclusion and exclusion criteria from 30 teenage athletes in PASI East Java sprints. The Data were collected by measuring the sprint results by finish photo camera and laboratory examinations to determine the levels of antioxidants (SOD) and the inflammation degree (TNF-α) in blood. The data were analyzed using multivariate technique (Manova) Hotelling’s method (T2). Hypothesis testing using α = 0.05. The results and conclusions of the study stated that the normal diet had no effect on the variables of sprint running speed, SOD and TNF-α levels. While low-carbohydrate and high-protein diet can increase SOD levels of 211.44/gHb, reduce (TNF-α) at least 0.309 pg/ml, and the average increase in antioxidant activity caused by low-carbohydrate-high-protein diet is 24.989/gHb higher than normal diet, the decrease in the degree of inflammation is 0.196 pg/ml, however, it has no effect on the speed of sprint.

Dietary protein does not alter intrinsic reactivity of renal microcirculation to angiotensin II in rodents

1995 ◽  
Vol 268 (2) ◽  
pp. F302-F308 ◽  
Author(s):  
S. R. Inman ◽  
N. T. Stowe ◽  
J. V. Nally ◽  
B. H. Brouhard ◽  
D. G. Vidt
Keyword(s):  
Angiotensin Ii ◽  
Dietary Protein ◽  
Vascular Reactivity ◽  
High Protein Diet ◽  
Normal Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Renal Microcirculation ◽  
Low Protein

The effect of dietary protein on renal function and on renal microvascular reactivity to angiotensin II was determined in rats fed a high-protein diet (40% protein), a low-protein diet (6% protein), or a normal diet (23% protein). Inulin clearance was higher in high-protein-fed rats (n = 7) than in rats fed a low-protein diet (n = 7), 0.88 +/- 0.14 (means +/- SE) vs. 0.54 +/- 0.07 ml.min-1.g kidney wt-1 (P < 0.05). We also used videomicroscopy to assess the effect of angiotensin II on the renal microcirculation in a hydronephrotic kidney preparation. The afferent and efferent arterioles constricted to angiotensin II and norepinephrine in both high- and low-protein-fed rats; this constriction was diminished to angiotensin II but not to norepinephrine, in rats fed a high-protein diet (-24.3 +/- 4.5, -20.2 +/- 4.2%) compared with rats fed a low-protein diet (-39 +/- 5.1, -39.1 +/- 5.7%). The vasoconstrictor responses to angiotensin II in rats fed a high-protein diet and a normal diet were significantly greater following inhibition of angiotensin II formation with captopril but not in low-protein-fed rats. The apparent high-endogenous level of angiotensin II among rats fed a high-protein diet may account for the diminished reactivity to exogenous angiotensin II. Thus alterations in intrinsic vascular reactivity to angiotensin II are not responsible for the altered hemodynamics associated with dietary protein.

scholarly journals A High Protein Diet Has No Harmful Effects: A One-Year Crossover Study in Resistance-Trained Males

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Jose Antonio ◽  
Anya Ellerbroek ◽  
Tobin Silver ◽  
Leonel Vargas ◽  
Armando Tamayo ◽  
...  
Keyword(s):  
Blood Lipids ◽  
High Protein Diet ◽  
Normal Diet ◽  
High Protein ◽  
Protein Diet ◽  
Bod Pod ◽  
Self Reports ◽  
Liver And Kidney ◽  
One Year ◽  
Harmful Effects

The purpose of this investigation was to determine the effects of a high protein diet over a one-year period. Fourteen healthy resistance-trained men completed the study (mean ± SD; age26.3±3.9 yr; height178.5±8.4 cm; and average years of training8.9±3.4 yr). In a randomized crossover design, subjects consumed their habitual or normal diet for 2 months and 4 months and alternated that with a higher protein diet (>3 g/kg/d) for 2 months and 4 months. Thus, on average, each subject was on their normal diet for 6 months and a higher protein diet for 6 months. Body composition was assessed via the Bod Pod®. Each subject provided approximately 100–168 daily dietary self-reports. During the subjects’ normal eating phase, they consumed (mean ± SD)29.94±5.65 kcals/kg/day and2.51±0.69 g/kg/day of protein. This significantly increased (p<0.05) during the high protein phase to34.37±5.88 kcals/kg/day and3.32±0.87 g/kg/day of protein. Our investigation discovered that, in resistance-trained men that consumed a high protein diet (~2.51–3.32 g/kg/d) for one year, there were no harmful effects on measures of blood lipids as well as liver and kidney function. In addition, despite the total increase in energy intake during the high protein phase, subjects did not experience an increase in fat mass.

scholarly journals A high-protein diet increases faecal IgA concentrations in baby pigs

2008 ◽  
Vol 67 (OCE5) ◽  
Author(s):  
F. Vitari ◽  
A. Morise ◽  
M. Formal ◽  
C. Garcia ◽  
K. Mace ◽  
...  
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

scholarly journals Measurement of the Intestinal pH in Mice under Various Conditions Reveals Alkalization Induced by Antibiotics

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 180
Author(s):  
Kouki Shimizu ◽  
Issei Seiki ◽  
Yoshiyuki Goto ◽  
Takeshi Murata
Keyword(s):  
Antibiotic Treatment ◽  
High Protein Diet ◽  
Intestinal Bacteria ◽  
High Protein ◽  
Protein Diet ◽  
Germ Free ◽  
Treatment Regimens ◽  
Ph Values ◽  
Specific Pathogen ◽  
The Stability

The intestinal pH can greatly influence the stability and absorption of oral drugs. Therefore, knowledge of intestinal pH is necessary to understand the conditions for drug delivery. This has previously been measured in humans and rats. However, information on intestinal pH in mice is insufficient despite these animals being used often in preclinical testing. In this study, 72 female ICR mice housed in SPF (specific pathogen-free) conditions were separated into nine groups to determine the intestinal pH under conditions that might cause pH fluctuations, including high-protein diet, ageing, proton pump inhibitor (PPI) treatment, several antibiotic treatment regimens and germ-free mice. pH was measured in samples collected from the ileum, cecum and colon, and compared to control animals. An electrode, 3 mm in diameter, enabled accurate pH measurements with a small amount of gastrointestinal content. Consequently, the pH values in the cecum and colon were increased by high-protein diet, and the pH in the ileum was decreased by PPI. Drastic alkalization was induced by antibiotics, especially in the cecum and colon. The alkalized pH values in germ-free mice suggested that the reduction in the intestinal bacteria caused by antibiotics led to alkalization. Alkalization of the intestinal pH caused by antibiotic treatment was verified in mice. We need further investigations in clinical settings to check whether the same phenomena occur in patients.

scholarly journals The Colonic Microbiome and Epithelial Transcriptome Are Altered in Rats Fed a High-Protein Diet Compared with a Normal-Protein Diet

2016 ◽  
Vol 146 (3) ◽  
pp. 474-483 ◽  
Author(s):  
Chunlong Mu ◽  
Yuxiang Yang ◽  
Zhen Luo ◽  
Leluo Guan ◽  
Weiyun Zhu
Keyword(s):  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Normal Protein Diet
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