scholarly journals Factors influencing IgG response against SARS-CoV-2: A quantitative serological survey among healthcare workers of a COVID-19 dedicated health facility in India

2021 ◽  
Vol 0 ◽  
pp. 1-8
Author(s):  
Mala Mahto ◽  
Bijit Biswas ◽  
Ayan Banerjee ◽  
Sushil Kumar ◽  
Neeraj Agarwal ◽  
...  

Objectives: The objectives of the study were to explore the factors influencing serum IgG response against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) among healthcare workers (HCWs) of a tertiary healthcare facility in India. Material and Methods: It was a monocentric, observational study during the month of September 2020. In the study, a cross-sectional quantitative serological assessment of IgG response against SARS-CoV-2 among HCWs of All India Institute of Medical Sciences (AIIMS), Patna, Bihar, was done using a chemiluminescent immunoassay (CLIA) platform named “ADVIA Centaur COV2G.” Statistical Package for the Social Sciences (SPSS) (version 22.0) was used for data analysis. Results: Among the study subjects, 761 (82.8%) had detectable serum IgG traces against SARS-CoV-2 with median (interquartile range [IQR]) of 0.03 (0.01–0.08). Those who were male by gender (spearman rho correlation co-efficient [ρ] = 0.08; P ≤ 0.05), technician (ρ= 0.07; P ≤ 0.05), attendant (ρ= 0.19; P ≤ 0.01), and sanitary staff (ρ= 0.13; P ≤ 0.01) by occupation, posted in laboratories (ρ= 0.09; P ≤ 0.01), had prior SARS-CoV-2 infection (ρ= 0.26; P ≤ 0.01), used to take steam inhalation (ρ= 0.10; P ≤ 0.01), preferred non-vegetarian diet (ρ= 0.10; P ≤ 0.01), consumed azithromycin (ρ= 0.13; P ≤ 0.01), zinc (ρ= 0.08; P ≤ 0.05) had significantly higher whereas doctors (ρ= −0.10; P ≤ 0.01), and nurses (ρ= −0.16; P ≤ 0.01) had significantly lower serum IgG response against SARS-CoV-2 compared to others. Conclusion: Gender, occupation, place of posting, prior SARS-CoV-2 infection, use of steam inhalation, diet preference, consumption of azithromycin, and zinc emerged as significant attributes of serum IgG response against SARS-CoV-2 among the study subjects.

2018 ◽  
Author(s):  
Usman Rabi ◽  
Ahmad A. Umar ◽  
Saheed Gidado ◽  
A.A Gobir ◽  
Izuchukwu F. Obi ◽  
...  

AbstractIntroductionEarly diagnosis and prompt and effective treatment is one of the pillars of malaria control Malaria case management guidelines recommend diagnostic testing before treatment using malaria Rapid Diagnostic Test (mRDT) or microscopy and this was adopted in Nigeria in 2010. However, despite the deployment of mRDT, the use of mRDTs by health workers varies by settings. This study set out to assess factors influencing utilisation of mRDT among healthcare workers in Zamfara State, Nigeria.MethodsA cross-sectional study was carried out among 306 healthcare workers selected using multistage sampling from six Local Government Areas between January and February 2017. Mixed method was used for data collection. A pre-tested self-administered questionnaire was used to collect information on knowledge, use of mRDT and factors influencing utilization. An observational checklist was used to assess the availability of mRDT in the six months prior to this study. Data were analyzed using descriptive statistics such as means and proportions. Association between mRDT use and independent variables was tested using Chi square while multiple regression was used to determine predictors of use at 5% level of significance.ResultsMean age of respondents was 36.0 ± 9.4years. Overall, 198 (64.7%) of health workers had good knowledge of mRDT; malaria RDT was available in 33 (61.1%) facilities. Routine use of mRDT was reported by 253 (82.7%) healthcare workers. This comprised 89 (35.2%) laboratory scientists/technicians, 89 (35.2%) community health extension workers/community health officers; 59 (23.3%) nurses and 16 (6.3%) doctors. Predictors of mRDT utilisation were good knowledge of mRDT (adjusted OR (aOR):3.3, CI: 1.6-6.7), trust in mRDT results (aOR: 4.0, CI: 1.9 - 8.2), having being trained on mRDT (aOR: 2.7, CI: 1.2 - 6.6), and provision of free mRDT (aOR: 2.3, CI: 1.0 - 5.0).ConclusionThis study demonstrated that healthcare worker utilisation of mRDT was associated with health worker and health system-related factors that are potentially modifiable. There is need to sustain training of healthcare workers on benefits of using mRDT and provision of free mRDT in health facilities.


2017 ◽  
Vol 19 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Marzieh Honarbakhsh ◽  
Mehdi Jahangiri ◽  
Haleh Ghaem

Background: Using appropriate respiratory protection equipment (RPE) is very important to protect healthcare workers (HCWs) against respiratory hazards. The aim of this study was to identify the level of knowledge, perceptions and practices of HCWs on using RPE. Methods: This cross-sectional study was conducted with 284 employees of educational hospitals affiliated to Shiraz University of Medical Sciences. The study’s instrument was a self-made questionnaire that comprised four components: demographic inquiries and questions designed to assess the knowledge, perceptions and practice of HCWs regarding RPE. Collected data were analysed using SPSS software version 21. Results: Average scores of knowledge, perceptions and practice of HCWs on using RPE were 66.50% ± 11.93%, 80.32% ± 10.05% and 70.12% ± 20.51%, respectively. A significant association was observed between knowledge and age, job experience, history of using respirator, marital status and risk of respiratory hazards in the workplace and perceptions with age and education and practice with education. Conclusion: Studied HCWs had positive perceptions and moderate level of knowledge and practice about the use of RPE. Full implementation of respiratory protection program in the hospitals would be helpful to improve the knowledge, perceptions and practices of HCWs regarding RPE.


2020 ◽  
Vol 11 (3) ◽  
pp. 4039-4046
Author(s):  
Kapil P. Sawarkar ◽  
Pramod Shah

The current study was based on Computed Tomography (CT) findings and results. We found 63% of patients with acute interstitial edematous pancreatitis, and we found 37% of patients with acute necrotic pancreatitis in 46 cases. Based on our findings, we observed bulky pancreas among 26 cases (56.52%), 17 cases (36.95%) of pancreatic necrosis, 9 cases of pancreatic atrophy, 11 cases of pseudocyst, and 9 cases of peri-pancreatic fluid. When we evaluated the Modified CT Severity index among the study cases, we observed that 19.56% cases have mild index, the majority (56.52% cases) have moderate index while 23.91% have severe index. We also found that majority of the cases were clinically cured and discharged, i.e., 47.82%. 19.56% of the total study subjects reported recurrence of episodes of pancreatitis, while 30.43% of the total patients turned into chronic pancreatitis. This study presents a cross-sectional hospital-based analytical study carried out among 46 cases of AP referred to under the radiology department for further diagnostic evaluation, in a tertiary healthcare facility in Maharashtra. The present study Data Source included all the AP patients referred to the radiological department in a tertiary health research center. They met the standards for inclusiveness, which assented to the analysis. Type of study is Hospital analytical based study. The study duration is 18 months. Data collection was done through semi-structured, pre-designed, and pre-validated proformas in patients meeting inclusion requirements that included disease history, clinical outcomes, investigative records, and descriptions of surgical interventions.


Author(s):  
K. Jahnavi ◽  
Abhay Subhashrao Nirgude ◽  
Kondagunta Nagaraj

Background: Promoting women’s health improves not only individual health but also the health of the family, community and the nation. Less attention was given for postnatal period in developing countries; women and their newborns don’t receive postnatal care services from a skilled birth attendant during the first days after childbirth. The objective was to study utilization of postnatal care services by recently delivered mothers, to study the geographical accessibility factors influencing utilization of postnatal care services and to study healthcare provider factors influencing utilization of post natal care services.Methods: It was a community based cross sectional study conducted in Cherlapally and villages around, which constitute the rural field practice area of Department of SPM, Kamineni Institute of Medical Sciences, Narketpally Telangana from September 2012 to October 2014. A pre-designed and pre-tested questionnaire was used to collect the data. The data was compiled and analyzed using SPSS version 19.Results: Accordingly, 97.9% of the mothers received postnatal care and 2.7% mothers didn’t receive the postnatal care. In the present study post natal advice was received by 67.8%, 82.2% and 55.1% of mothers regarding family planning, breast feeding and baby care respectively. Majority (79.9%) of mothers travelled greater than 5 kms for delivery and only 20.1% of mothers travelled less than 5 kms for delivery.Conclusions: Number of institutional deliveries and deliveries assisted by skilled health personnel were more compared to other studies probably because of awareness created during antenatal visits, maternity benefit scheme and role of ASHA workers.


Author(s):  
Bedriye Muge Sonmez ◽  
Fevzi Yilmaz ◽  
Murat Dogan Iscanli ◽  
Cihat Yel ◽  
Ali Demir ◽  
...  

Abstract Objectives: To evaluate inmate referrals to emergency department of a tertiary healthcare facility in terms of demographical and clinical characteristics as well as their impact on the department. Method: The retrospective cross-sectional study was conducted at Ankara Numune Training and Research Hospital, Ankara, Turkey, and comprised data of incarcerated patients who were brought to the emergency department from January 01, 2010, to December 31, 2012. . Demographical characteristics, consultations, duration of hospitalisation, recurrent admissions, disposal and mortality rates were noted. The referrals were grouped as surgical conditions, medical disorders, Eye, Ear, Nose, Throat problems, injury and psychiatric disorders. The groups were then subdivided according to diagnosis. SPSS 22 was used for data analysis. Results: Of the 856 patients, 804(93.4%) were men and 52(6.1%) were women. The overall mean age was 37.54±14.81 years (range: 15-83 years). The number of patients was the highest in the medical group 363(42.4%) and the lowest in the Eye, Ear, Nose, Throat group 56(6.5%). Mean age of the surgical group was significantly lower than the medical group (p<0.001) but significantly higher than that of the trauma group (p=0.001). Conclusion: Functional emergency response units, strict emergency triage of inmates, and their rapid care and management in jails can help avoid referring these patients to already overcrowded emergency departments. Key Words: Prisoners, Healthcare, Emergency department.


2021 ◽  
Vol 12 ◽  
Author(s):  
Joseph O. Fadare ◽  
Abimbola Margaret Obimakinde ◽  
Felix O. Aina ◽  
Ebisola J. Araromi ◽  
Theophilus Adekunle Adegbuyi ◽  
...  

Background: The use of drugs with anticholinergic effects among elderly patients is associated with adverse clinical outcomes. There is paucity of information about anticholinergic drug burden among Nigerian elderly population.Objectives: To determine the anticholinergic drug burden among elderly Nigerian patients.Methods: This was a retrospective cross-sectional study conducted among elderly patients (aged 65 and above) who visited the Family Medicine outpatients’ clinics of the Ekiti State University Teaching Hospital, Ado-Ekiti, Nigeria between July 1 and October 31, 2018. Information extracted from the case files included patient’s age, sex, diagnoses, and list of prescribed medications. Medicines with anticholinergic effects were identified and scored using the anticholinergic drug burden calculator (http://www.acbcalc.com).Results: The medical records of 400 patients were analyzed with females accounting for 60.5% of the study population. The mean age of participants was 73 ± 7.4 years with only 28 (7%) of patients having more than two co-morbid conditions. Polypharmacy was identified in 152 (38%) of the patients while 147 (36.7%) had drugs with anticholinergic effects prescribed. The anticholinergic burden was high in 60 (15%) patients. Polypharmacy was significantly associated with having more than two diagnosed conditions and high anticholinergic burden (p value of &lt; 0 .001 and 0.013 respectively). There was significant correlation between total number of prescribed drugs and count of diagnoses (r = 0.598; p &lt; 0 .000) and between total number of prescribed drugs and number of drugs with anticholinergic effects (r = 0 .196; p &lt; 0 .000).Conclusion: The anticholinergic burden in this group of elderly Nigerian patients was low; majority (67%) had no exposure to drugs with anticholinergic effects with only 15% having high anticholinergic burden. Polypharmacy and multiple diagnosed conditions were positively associated with high anticholinergic burden. Based on the positive and significant correlations found in this study, a reduction in the number of prescribed medicines especially those with significant anticholinergic effects used for secondary indications may lessen the anticholinergic burden among the elderly.


Author(s):  
Emmanuel N. Omoijiade ◽  
Lucky Evbuomwan

Background: Generally, personal protective equipment (PPE) should be used by healthcare workers, as they provide a physical barrier between hazards and the wearer. Exposure to occupational hazards in the laundry can be limited by the use of PPE such as barrier gowns, gloves, eyewear, foot coverings and face masks. This study provides information on the PPE compliance of the workers at the laundry, as this would prove useful in order to establish appropriate interventions to minimize occupational risks of workers in the healthcare laundries.Methods: This study was a comparative cross-sectional study. It was conducted in six hospitals with a laundry department in Benin-city, composed of one available tertiary healthcare facility and five secondary healthcare facilities. Questionnaire was administered to the workers concerning the availability and use of PPE.Results: The common PPE used were nose masks (7.9%), hand gloves (39.5%), safety boots (3.6%) and coveralls (84.5%). Respondents revealed that eye goggles or face shields and ear plugs or muffs were never provided for them.Conclusions: Compliance of respondents to PPE was not at an optimally recommended level. It is recommended that efforts be made to ensure that workers comply with PPE use, while providing all necessary protective equipment, which should first be assessed before selection and use.


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