scholarly journals Enhancement of Biomass and Secondary Metabolite Production of St. John's Wort (Hypericum perforatum L.) under a Controlled Environment

2006 ◽  
Vol 44 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Kriengkrai MOSALEEYANON ◽  
Sayed M. A. ZOBAYED ◽  
Fawzia AFREEN ◽  
Toyoki KOZAI
Keyword(s):  
Secondary Metabolite ◽  
Hypericum Perforatum ◽  
Secondary Metabolite Production ◽  
Controlled Environment ◽  
Metabolite Production ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Hypericin content of Nova Scotia biotypes of Hypericum perforatum L.

1995 ◽  
Vol 75 (4) ◽  
pp. 923-926 ◽  
Author(s):  
K. I. N. Jensen ◽  
S. O. Gaul ◽  
E. G. Specht ◽  
D. J. Doohan
Keyword(s):  
Nova Scotia ◽  
Vegetative Growth ◽  
Hypericum Perforatum ◽  
Colletotrichum Gloeosporioides ◽  
Controlled Environment ◽  
St John’S Wort ◽  
St John's Wort ◽  
Environment Study ◽  
Hypericum Perforatum L ◽  
The Mean

Photosensitization of livestock in Nova Scotia has often been attributed to St. John's wort (Hypericum perforatum L.), even though the weed generally occurs at low densities. This study's objective was to determine whether levels of hypericin, the photodynamic toxin causing photosensitization, were unusually high in Nova Scotia biotypes and whether levels increased in late spring, when photosensitization most commonly occurs. The mean hypericin content in vegetative growth of 11 Nova Scotia H. perforatum biotypes was 195 μg g−1 dry wt, whereas levels in biotypes from British Columbia and Australia were at least two- and threefold higher, respectively. Levels in field-collected plants were lowest in May (60 μg g−1 dry wt) and peaked in midsummer (160–280 μg g−1 dry wt). In a controlled-environment study, hypericin levels increased linearly with increasing temperatures. Furthermore, hypericin levels were not affected by infection by Colletotrichum gloeosporioides. Thus, the hypericin content of Nova Scotia biotypes is too low to be the cause of photosensitization in livestock. Key words:Hypericum perforatum, St. John's wort, hypericin, photosensitization

St. John’s wort (Hypericum perforatum L.): Challenges and strategies for production of chemically-consistent plants

2006 ◽  
Vol 86 (3) ◽  
pp. 765-771 ◽  
Author(s):  
Susan J. Murch ◽  
Praveen K. Saxena
Keyword(s):  
Medicinal Plant ◽  
Large Scale ◽  
Hypericum Perforatum ◽  
Controlled Environment ◽  
Natural Health Products ◽  
Scale Production ◽  
Plant Products ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Plants are by far the most important source of natural therapeutics, and the role of plants in enhancing the longevity and the quality of life is increasingly accepted throughout the world. A series of problems with medicinal plant products, such as contamination with biological and environmental pollutants, quantitative and qualitative variations of bioactive compounds, adulteration with misidentified species, and the concern of unsustainable harvest, has prompted the introduction of regulations to ensure the quality and safety of medicinal plant products in Canada. In the future, Natural Health Products in Canada will be manufactured to a new standard of quality and these changes in the industry have necessitated new approaches to the breeding, production, and processing of medicinal plant tissues. The continuing growth in the medicinal plant marketplace has also brought about the challenge of maintaining a balance between consumer demand and the need to protect medicinal biodiversity. St. John’s wort (Hypericum perforatum L.) is one of the most popular medicinal plants with a history of use spanning more than two millennia and modern studies demonstrating efficacy. However, inconsistencies in the results of various clinical trials and difficulties in identifying a specific medicinal molecule with defined pharmaceutical function prompted our efforts to improve St. John’s wort products. Development of elite varieties with predictable phytochemical profiles, mass clonal propagation in vitro, large-scale production in sterile environments and controlled environment production systems, have been combined to produce a new standard in the production of St. John’s wort. Key words: St. John's wort, chemical consistency, hyperforin, melatonin, controlled environment systems

scholarly journals Secondary metabolite production in Hypericum perforatum L. cell suspensions upon elicitation with fungal mycelia from Aspergillus flavus

2012 ◽  
Vol 64 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Sonja Gadzovska-Simic ◽  
O. Tusevski ◽  
S. Antevski ◽  
Natalija Atanasova-Pancevska ◽  
Jasmina Petreska ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Aspergillus Flavus ◽  
Hypericum Perforatum ◽  
Cell Suspension Cultures ◽  
Cell Suspensions ◽  
Secondary Metabolite Production ◽  
Medicinal Uses ◽  
Metabolite Production ◽  
L Cell ◽  
Hypericum Perforatum L

We investigated the production of phenylpropanoids (phenolic compounds, flavanols, flavonols and anthocyanins) and naphtodianthrones (hypericins) in elicited Hypericum perforatum L. cell suspensions. To determine whether secondary metabolite production could be enhanced, Hypericum cell suspensions were exposed to mycelia extract from the fungus Aspergillus flavus. Elicited Hypericum cell suspension cultures displayed reduced growth and viability and a modification of secondary metabolites production. Anthocyanins were only stimulated in fungal-elicited cell suspensions. Secondary metabolite production in elicited Hypericum cells revealed an antagonism between the flavonoid/naphtodianthrone and anthocyanin pathways. The data suggest a modification of the channeling of the phenylpropanoid compounds. Together, these results represent useful data for monitoring the channeling in different secondary metabolite pathways during the scaled-up production of naphtodianthrones for medicinal uses.

Determination of Hypericin in St. John's Wort (Hypericum perforatum L.) extracts using HPLC-ED

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
E Sofic ◽  
A Copra Janicijevic ◽  
M Maksimovic ◽  
I Tahirovic ◽  
L Klepo ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L

Effect of herbicides on St John's wort (Hypericum perforatum L.)

1991 ◽  
Vol 31 (4) ◽  
pp. 499 ◽  
Author(s):  
MH Campbell ◽  
BR Milne ◽  
JJ Dellow ◽  
HI Nicol
Keyword(s):  
Hypericum Perforatum ◽  
New South ◽  
Arable Land ◽  
Ground Cover ◽  
Aerial Application ◽  
St John’S Wort ◽  
Strong Trend ◽  
St John's Wort ◽  
South Wales ◽  
Hypericum Perforatum L

The effect of type of herbicide and time and rate of application on the reduction in ground cover of St John's wort (Hypericum perforatum L.) was determined at Orange, New South Wales. In January, April, July and November 1988, 8 herbicide treatments including the currently used glyphosate and picloram + 2,4-D were applied to vigorously growing H. perforaturn, and the reduction in percentage ground cover was recorded in December 1989. Ineffective herbicides (a.i./ha) were tebuthiuron, 0.8-6.4 kg; metsulfuron, 5-20 g; and paraquat + diquat, 0.4 + 0.5 kg. The addition of metsulfuron (2.5 g a.i./ha) to glyphosate (0.9 and 1.8 kg a.i./ha) did not increase the effectiveness of the latter. Effective herbicides (kg a.i./ha) were triclopyr + picloram, 0.6 + 0.2; picloram + 2,4-D, 0.2 + 0.8; glyphosate, 1.8; and triclopyr, 1.92. There was a strong trend for these herbicides to be more effective in January and November than in April and July. Based on price, effectiveness and selectivity, triclopyr + picloram would be preferred to the other herbicides for boom and spot spraying, and glyphosate would be the only herbicide suitable for aerial application prior to sowing improved pastures on non-arable land.

EXTRACTION OF HYPERFORIN AND HYPERICIN FROM ST. JOHN'S WORT (HYPERICUM PERFORATUM L.) WITH DIFFERENT SOLVENTS

2011 ◽  
Vol 35 (2) ◽  
pp. 222-235 ◽  
Author(s):  
DÁNIEL COSSUTA ◽  
TÜNDE VATAI ◽  
MÁRIA BÁTHORI ◽  
JUDIT HOHMANN ◽  
TIBOR KEVE ◽  
...  
Keyword(s):  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort ◽  
Hypericum Perforatum L
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