scholarly journals Secondary metabolite production in Hypericum perforatum L. cell suspensions upon elicitation with fungal mycelia from Aspergillus flavus

2012 ◽  
Vol 64 (1) ◽  
pp. 113-121 ◽  
Author(s):  
Sonja Gadzovska-Simic ◽  
O. Tusevski ◽  
S. Antevski ◽  
Natalija Atanasova-Pancevska ◽  
Jasmina Petreska ◽  
...  
Keyword(s):  
Secondary Metabolite ◽  
Aspergillus Flavus ◽  
Hypericum Perforatum ◽  
Cell Suspension Cultures ◽  
Cell Suspensions ◽  
Secondary Metabolite Production ◽  
Medicinal Uses ◽  
Metabolite Production ◽  
L Cell ◽  
Hypericum Perforatum L

We investigated the production of phenylpropanoids (phenolic compounds, flavanols, flavonols and anthocyanins) and naphtodianthrones (hypericins) in elicited Hypericum perforatum L. cell suspensions. To determine whether secondary metabolite production could be enhanced, Hypericum cell suspensions were exposed to mycelia extract from the fungus Aspergillus flavus. Elicited Hypericum cell suspension cultures displayed reduced growth and viability and a modification of secondary metabolites production. Anthocyanins were only stimulated in fungal-elicited cell suspensions. Secondary metabolite production in elicited Hypericum cells revealed an antagonism between the flavonoid/naphtodianthrone and anthocyanin pathways. The data suggest a modification of the channeling of the phenylpropanoid compounds. Together, these results represent useful data for monitoring the channeling in different secondary metabolite pathways during the scaled-up production of naphtodianthrones for medicinal uses.

Jasmonic acid elicitation of Hypericum perforatum L. cell suspensions and effects on the production of phenylpropanoids and naphtodianthrones

2007 ◽  
Vol 89 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Sonja Gadzovska ◽  
Stéphane Maury ◽  
Alain Delaunay ◽  
Mirko Spasenoski ◽  
Claude Joseph ◽  
...  
Keyword(s):  
Jasmonic Acid ◽  
Hypericum Perforatum ◽  
Cell Suspensions ◽  
L Cell ◽  
Hypericum Perforatum L

Cell division versus secondary metabolite production in Morinda citrifolia cell suspensions

1997 ◽  
Vol 150 (3) ◽  
pp. 325-330 ◽  
Author(s):  
Marc J.M. Hagendoorn ◽  
Diaan C.L. Jamar ◽  
Barbara Meykamp ◽  
Linus H.W. van der Plas
Keyword(s):  
Cell Division ◽  
Secondary Metabolite ◽  
Cell Suspensions ◽  
Morinda Citrifolia ◽  
Secondary Metabolite Production ◽  
Metabolite Production

scholarly journals Cytoplasmic Acidification and Secondary Metabolite Production in Different Plant Cell Suspensions (A Comparative Study)

1994 ◽  
Vol 106 (2) ◽  
pp. 723-730 ◽  
Author(s):  
MJM. Hagendoorn ◽  
A. M. Wagner ◽  
G. Segers ◽  
LHW. van der Plas ◽  
A. Oostdam ◽  
...  
Keyword(s):  
Comparative Study ◽  
Secondary Metabolite ◽  
Plant Cell ◽  
Cell Suspensions ◽  
Secondary Metabolite Production ◽  
Metabolite Production ◽  
Cytoplasmic Acidification

scholarly journals The impact of bZIP Atf1ortholog global regulators in fungi

2021 ◽  
Author(s):  
Éva Leiter ◽  
Tamás Emri ◽  
Klaudia Pákozdi ◽  
László Hornok ◽  
István Pócsi
Keyword(s):  
Transcription Factors ◽  
Stress Response ◽  
Secondary Metabolite ◽  
Plant Pathogens ◽  
Leucine Zipper ◽  
Secondary Metabolite Production ◽  
Special Focus ◽  
Human Pathogens ◽  
Metabolite Production ◽  
The Impact

Abstract Regulation of signal transduction pathways is crucial for the maintenance of cellular homeostasis and organismal development in fungi. Transcription factors are key elements of this regulatory network. The basic-region leucine zipper (bZIP) domain of the bZIP-type transcription factors is responsible for DNA binding while their leucine zipper structural motifs are suitable for dimerization with each other facilitiating the formation of homodimeric or heterodimeric bZIP proteins. This review highlights recent knowledge on the function of fungal orthologs of the Schizosaccharomyces pombe Atf1, Aspergillus nidulans AtfA, and Fusarium verticillioides FvAtfA, bZIP-type transcription factors with a special focus on pathogenic species. We demonstrate that fungal Atf1-AtfA-FvAtfA orthologs play an important role in vegetative growth, sexual and asexual development, stress response, secondary metabolite production, and virulence both in human pathogens, including Aspergillus fumigatus, Mucor circinelloides, Penicillium marneffei, and Cryptococcus neoformans and plant pathogens, like Fusarium ssp., Magnaporthe oryzae, Claviceps purpurea, Botrytis cinerea, and Verticillium dahliae. Key points • Atf1 orthologs play crucial role in the growth and development of fungi. • Atf1 orthologs orchestrate environmental stress response of fungi. • Secondary metabolite production and virulence are coordinated by Atf1 orthologs.

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