A Simple Method of Matric Structural Analysis: Part IV - Nonlinear Problems

1959 ◽  
Vol 26 (6) ◽  
pp. 351-359 ◽  
Author(s):  
BERTRAM KLEIN
Keyword(s):  
Structural Analysis ◽  
Nonlinear Problems ◽  
Simple Method

scholarly journals Structural analysis of human dual-specificity phosphatase 22 complexed with a phosphotyrosine-like substrate

2015 ◽  
Vol 71 (2) ◽  
pp. 199-205 ◽  
Author(s):  
George T. Lountos ◽  
Scott Cherry ◽  
Joseph E. Tropea ◽  
David S. Waugh
Keyword(s):  
Crystal Structure ◽  
Structural Analysis ◽  
Phosphatase Activity ◽  
Small Molecule ◽  
Molecular Basis ◽  
Protein Tyrosine Phosphatases ◽  
Simple Method ◽  
Dual Specificity Phosphatase ◽  
Dual Specificity ◽  
Nitrophenyl Phosphate

4-Nitrophenyl phosphate (p-nitrophenyl phosphate, pNPP) is widely used as a small molecule phosphotyrosine-like substrate in activity assays for protein tyrosine phosphatases. It is a colorless substrate that upon hydrolysis is converted to a yellow 4-nitrophenolate ion that can be monitored by absorbance at 405 nm. Therefore, the pNPP assay has been widely adopted as a quick and simple method to assess phosphatase activity and is also commonly used in assays to screen for inhibitors. Here, the first crystal structure is presented of a dual-specificity phosphatase, human dual-specificity phosphatase 22 (DUSP22), in complex with pNPP. The structure illuminates the molecular basis for substrate binding and may also facilitate the structure-assisted development of DUSP22 inhibitors.

A method for the derivation of load effect envelopes based on statistical considerations

1993 ◽  
Vol 20 (2) ◽  
pp. 201-209
Author(s):  
Eugene J. O'Brien ◽  
Robert E. Loov
Keyword(s):  
Structural Analysis ◽  
Three Dimensional ◽  
Elastic Analysis ◽  
Two Dimensional ◽  
Statistical Parameters ◽  
Simple Method ◽  
Load Effect ◽  
Linear Elastic ◽  
Derived Design ◽  
Usual Process

A simple method is proposed as a substitute for the usual process of factoring loads, performing a linear elastic analysis, and determining an envelope of the results. The method is based on statistical principles, but only a minimum knowledge of statistics is required for its use. It involves conventional structural analysis followed by some processing of the results which could readily be incorporated into existing computer programs.The practice of performing two-dimensional analyses on parts of three-dimensional structures is possible with the proposed approach. The implications are clarified and the necessary statistical parameters are derived.Deterministically derived design envelopes represent all the extremes of loading that can reasonably be considered. The envelopes found by the new method not only reflect loading variations but also consider their relative probabilities of occurrence so that excursions beyond the envelope are expected to be equally infrequent along the entire length of the structure. Inconsistencies inherent in the conventional approach are highlighted by comparison with the proposed method for a number of examples. Key words: probabilistic, safety, load, imposed load, load effect envelope, building.

scholarly journals USING THE NEW FIBRE CONTACT ELEMENT METHOD FOR DYNAMIC STRUCTURAL ANALYSIS

2015 ◽  
Vol 7 (1) ◽  
pp. 24-38
Author(s):  
João M. C. Estêvão ◽  
Ana S. Carreira
Keyword(s):  
Structural Analysis ◽  
Dynamic Response ◽  
Nonlinear Problems ◽  
Contact Element ◽  
Elastic Response ◽  
Reinforced Concrete Frame ◽  
Structural Dynamic ◽  
Concrete Frame ◽  
Contact Element Method ◽  
Element Method

In literature, there are many methods proposed for structural analysis based on discrete element formulations, mainly for nonlinear problems. One of these new methods is the Fibre Contact Element Method (FCEM). Many of these methods have been used for structural dynamic analysis problems. However, there are some questions about their precision in capturing the dynamic elastic response of structures when comparing to methods based on continuous models, like the well known Finite Element Method (FEM). For this reason, the results obtained with FCEM were extensively compared with FEM results and with laboratorial tests, to better understand the performance of this new method in capturing the elastic dynamic response of structures. Results indicate that this kind of discrete methods are able to determine the vibration modes of a structure with equal or better precision level than the obtained with FEM. FCEM was also used to capture the dynamic response of a reinforced concrete frame with infill walls, as a way to show the method capabilities in reproducing the dynamic behaviour of structures that have an almost continuous mass distribution.

Sign in / Sign up

Export Citation Format

Share Document