Recent Advances in Scale-Up Development of Molten Regolith Electrolysis for Oxygen Production in Support of a Lunar Base

2009 ◽  
Author(s):  
Laurent Sibille ◽  
Donald Sadoway ◽  
Aislinn Sirk ◽  
Prabhat Tripathy ◽  
Orlando Melendez ◽  
...  
Keyword(s):  
Scale Up ◽  
Oxygen Production ◽  
Recent Advances

scholarly journals Recent Advances in the BiVO4 Photocatalyst for Sun-Driven Water Oxidation: Top-Performing Photoanodes and Scale-Up Challenges

Catalysts ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. 13 ◽  
Author(s):  
Kristine Tolod ◽  
Simelys Hernández ◽  
Nunzio Russo
Keyword(s):  
Water Oxidation ◽  
Scale Up ◽  
Recent Advances

scholarly journals Fiber Generators in Needleless Electrospinning

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Haitao Niu ◽  
Tong Lin
Keyword(s):  
Production Rate ◽  
Scale Up ◽  
Electrospun Nanofibers ◽  
Scaling Up ◽  
Electrospinning Process ◽  
Recent Advances ◽  
Needleless Electrospinning ◽  
Application Potential

The conventional electrospinning often uses a needle-like nozzle to produce nanofibers with a very low production rate. Despite the enormous application potential, needle electrospun nanofibers meet difficulties in broad applications in practice, due to the lack of an economic and efficient way to scale up the electrospinning process. Recently, needleless electrospinning has emerged as a new electrospinning mode and shown ability to produce nanofibers on large-scales. It has been established that the fiber generator, also referred to as “spinneret” in this paper, in needleless electrospinning plays a key role in scaling up the nanofiber production. This paper summarizes the recent advances in the development of needleless spinnerets and their influences on electrospinning process, nanofiber quality, and productivity.

Application of microwave-assisted heterogeneous catalysis in sustainable synthesis design

2017 ◽  
Vol 19 (16) ◽  
pp. 3729-3751 ◽  
Author(s):  
Anne Kokel ◽  
Christian Schäfer ◽  
Béla Török
Keyword(s):  
Energy Efficiency ◽  
Heterogeneous Catalysis ◽  
Scale Up ◽  
Catalytic Synthesis ◽  
Microwave Assisted Synthesis ◽  
Heterogeneous Catalytic ◽  
Microwave Assisted ◽  
Synthesis Design ◽  
Recent Advances

Recent advances in the application of microwave-assisted heterogeneous catalytic synthesis approaches are reviewed with additional inputs on the energy efficiency and scale-up of microwave-assisted synthesis.

scholarly journals Cell-free protein synthesis: advances on production process for biopharmaceuticals and immunobiological products

BioTechniques ◽  
2021 ◽  
Vol 70 (2) ◽  
pp. 126-133
Author(s):  
Camila Hiromi Chiba ◽  
Marcos Camargo Knirsch ◽  
Adriano Rodrigues Azzoni ◽  
Antonio R Moreira ◽  
Marco Antonio Stephano
Keyword(s):  
Protein Synthesis ◽  
Production Process ◽  
Scale Up ◽  
Pharmaceutical Market ◽  
Free Protein ◽  
Recent Advances ◽  
Scale Down ◽  
Key Aspects ◽  
Cell Free Protein Synthesis

Biopharmaceutical products are of great importance in the treatment or prevention of many diseases and represent a growing share of the global pharmaceutical market. The usual technology for protein synthesis (cell-based expression) faces certain obstacles, especially with ‘difficult-to-express’ proteins. Cell-free protein synthesis (CFPS) can overcome the main bottlenecks of cell-based expression. This review aims to present recent advances in the production process of biologic products by CFPS. First, key aspects of CFPS systems are summarized. A description of several biologic products that have been successfully produced using the CFPS system is provided. Finally, the CFPS system's ability to scale up and scale down, its main limitations and its application for biologics production are discussed.

Recent Advances on Cellulose-Based Nano-Drug Delivery Systems: Design of Prodrugs and Nanoparticles

2019 ◽  
Vol 26 (14) ◽  
pp. 2410-2429 ◽  
Author(s):  
Lin Dai ◽  
Chuanling Si
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Low Cost ◽  
Drug Loading ◽  
Scale Up ◽  
Physicochemical Characterization ◽  
Systems Design ◽  
Delivery Systems ◽  
Recent Advances ◽  
Nano Drug Delivery

Background:Cellulose being the first abundant biopolymers in nature has many fascinating properties, including low-cost, good biodegradability, and excellent biocompatibility, which made cellulose a real potential material to create nano-drug delivery systems (nano-DDS). This review aims to present and discuss some remarkable recent advances on the drug delivery applications of cellulosebased prodrugs and nanoparticles.Methods:By searching the research literatures over last decade, a variety featured studies on cellulosebased nano-DDS were summarized and divided into prodrugs, prodrug nanoparticles, solid or derivative nanopartilces, amphiphilic copolymer nanoparticles, and polyelectrolyte complex nanoparticles. Various methods employed for the functionalization, pharmacodynamic actions and applications were described and discussed.Results:Many types of cellulose-based nano-DDS can ensure efficient encapsulation of various drugs and then overcome the free drug molecule shortcomings. Among all the method described, cellulosebased amphiphilic nanoparticles are most frequently used. These formulations have the higher drug loading capability, a simple and flexible way to achieve multi-functional. Apart from hydrophilic or hydrophobic modification, cellulose or its derivatives can form nanoparticles with different small molecules and macromolecules, leading to a large spectrum of cellulose-based nano-DDS and providing some unexpected advantages.Conclusion:Thorough physicochemical characterization and profound understanding of interactions of the cellulose-based nano-DDS with cells and tissues is indispensable. Moreover, studies toward technics parameter optimization and scale up from the laboratory to production level should be undertaken. The development of intravenous and orally applicable cellulose-based nano-DDS will be an important research area, and these systems will have more commercial status in the market.

scholarly journals AVANÇOS RECENTES NA SÍNTESE DO REMDESIVIR, MOLNUPIRAVIR (EIDD-2801) E TENOFOVIR: MOLÉCULAS PROMISSORAS NO TRATAMENTO DA COVID-19

Química Nova ◽  
2021 ◽  
Author(s):  
Taniris Braga ◽  
Juliana dos Santos ◽  
Pedro de Castro ◽  
Giovanni Amarante
Keyword(s):  
Scale Up ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
Research Groups ◽  
Pharmaceutical Ingredients ◽  
Recent Advances ◽  
New Treatments

RECENT ADVANCES IN THE SYNTHESIS OF REMDESIVIR, MOLNUPIRAVIR (EIDD-2801) AND TENOFOVIR: PROMISING MOLECULES IN THE TREATMENT OF COVID-19. The search for new treatments to contain the Covid-19 pandemic has highlighted the importance of nucleoside antivirals, such as Remdesivir, Tenofovir and Molnupiravir. Over the last two years, these molecules have been intensely investigated as promising alternatives against SARS-CoV-2 virus. Considering the increasingly demand for those substances, several research groups are intensely investigating synthetic developments in order to obtain these nucleoside derivatives and their intermediates in a fast, efficient and accessible manner. In this context, this review aims to in-depth present the recent advances concerning the preparation of Remdesivir, Tenofovir and Molnupiravir. Aspects involving differences in the starting materials and reagents, as well as the advantages and limitations of each protocol would be carefully disclosed. Moreover, the use of synthetic tools, such as flow chemistry, organocatalysis and biocatalysis, would also be detailed. Finally, this review also presents aspects involving the scale-up of these transformations, including discussions about stereo- and diastereoselectivity, as well as product isolation details. In summary, an overview of the existing synthetic strategies for these active pharmaceutical ingredients (APIs) are presented.

scholarly journals Recent advances on iron oxide magnetic nanoparticles as sorbents of organic pollutants in water and wastewater treatment

2017 ◽  
Vol 32 (1-2) ◽  
pp. 111-117 ◽  
Author(s):  
Angela M. Gutierrez ◽  
Thomas D. Dziubla ◽  
J. Zach Hilt
Keyword(s):  
Wastewater Treatment ◽  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Organic Pollutants ◽  
Scale Up ◽  
Cost Effective ◽  
Water And Wastewater Treatment ◽  
Recent Advances ◽  
Iron Oxide Magnetic Nanoparticles ◽  
Water And Wastewater

Abstract The constant growth in population worldwide over the past decades continues to put forward the need to provide access to safe, clean water to meet human needs. There is a need for cost-effective technologies for water and wastewater treatment that can meet the global demands and the rigorous water quality standards and at the same maximizing pollutant efficiency removal. Current remediation technologies have failed in keeping up with these factors without becoming cost-prohibitive. Most recently, nanotechnology has been sought as the best alternative to increase access to water supplies by remediating those already contaminated and offering ways to access unconventional sources. The use of iron oxide magnetic nanoparticles as nanoadsorbents has led way to a new class of magnetic separation strategies for water treatment. This review focuses on highlighting some of the most recent advances in core-shell iron oxide magnetic nanoparticles and nanocomposites containing iron oxide nanoparticles currently being developed for water and wastewater treatment of organic pollutants. We discuss the novelty of these novel materials and the insight gained from their advances that can help develop cost-effective reusable technologies for scale-up and commercial use.

scholarly journals The longstanding challenge of the nanocrystallization of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX)

2017 ◽  
Vol 8 ◽  
pp. 452-466 ◽  
Author(s):  
Florent Pessina ◽  
Denis Spitzer
Keyword(s):  
Particle Size ◽  
Energetic Materials ◽  
Scale Up ◽  
High Explosives ◽  
Recent Advances ◽  
Key Points ◽  
Pyrotechnic Compositions

Research efforts for realizing safer and higher performance energetic materials are continuing unabated all over the globe. While the thermites – pyrotechnic compositions of an oxide and a metal – have been finely tailored thanks to progress in other sectors, organic high explosives are still stagnating. The most symptomatic example is the longstanding challenge of the nanocrystallization of 1,3,5-trinitroperhydro-1,3,5-triazine (RDX). Recent advances in crystallization processes and milling technology mark the beginning of a new area which will hopefully lead the pyroelectric industry to finally embrace nanotechnology. This work reviews the previous and current techniques used to crystallize RDX at a submicrometer scale or smaller. Several key points are highlighted then discussed, such as the smallest particle size and its morphology, and the scale-up capacity and the versatility of the process.

scholarly journals Recent advances in the identification and prediction of polymorphs

2003 ◽  
Vol 3 (3) ◽  
pp. 32-36 ◽  
Author(s):  
Edina Vranić
Keyword(s):  
Crystallization Process ◽  
Scale Up ◽  
Gain Control ◽  
Structural Data ◽  
Phase Changes ◽  
Small Scale ◽  
Processing Conditions ◽  
Strategic Design ◽  
Recent Advances

An increased understanding of the phenomenon of polymorphism should enable pharmaceutical scientists to gain control over the crystallization process in order to selectively obtain the desired polymorph or suppress the growth of an undesired one. Phase changes during processing and scale-up are a problem, which may be avoided by carefully designed initial small-scale studies. The availability of detailed structural data, combined with strategic design of substrates and additives, has led to significant advances in the control over the polymorphs obtained in a particular crystallization. With all the information available from these initial studies, it should be possible to design and to select processing conditions which would give a desired polymorph and maintain the desired form throughout the various stages of drug processing and manufacture.

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