scholarly journals Modern Understanding of the Mechanisms of Adaptive Regulatory Adrenergic Effects

2016 ◽  
Vol 2016 (3) ◽  
pp. 35-46
Author(s):  
M. GZHEGOTSKYI ◽  
◽  
O. SHALKO ◽  
O. CHUPASHKO ◽  
L. PANINA ◽  
...  
Keyword(s):  
Adrenergic Effects

scholarly journals .BETA.-Adrenergic effects on salivary glands: Growth and gene regulation.

1990 ◽  
Vol 23 (2) ◽  
pp. 245-255 ◽  
Author(s):  
Setsuya Fujita ◽  
Tsukasa Ashihara ◽  
TIBOR BARKA
Keyword(s):  
Gene Regulation ◽  
Salivary Glands ◽  
Beta Adrenergic ◽  
Adrenergic Effects

scholarly journals Phospholemman-Phosphorylation Mediates the β-Adrenergic Effects on Na/K Pump Function in Cardiac Myocytes

2005 ◽  
Vol 97 (3) ◽  
pp. 252-259 ◽  
Author(s):  
Sanda Despa ◽  
Julie Bossuyt ◽  
Fei Han ◽  
Kenneth S. Ginsburg ◽  
Li-Guo Jia ◽  
...  
Keyword(s):  
Cardiac Myocytes ◽  
Pump Function ◽  
Adrenergic Effects

scholarly journals Adrenergic Effects on Ventricular Vulnerability

1964 ◽  
Vol 14 (6) ◽  
pp. 516-524 ◽  
Author(s):  
JAOK HAN ◽  
PERFECTO GARCIA DE JALON ◽  
GORDON K. MOE
Keyword(s):  
Adrenergic Effects

Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells

1997 ◽  
Vol 272 (2) ◽  
pp. H797-H805 ◽  
Author(s):  
R. P. Xiao ◽  
S. Pepe ◽  
H. A. Spurgeon ◽  
M. C. Capogrossi ◽  
E. G. Lakatta
Keyword(s):  
Intracellular Signaling ◽  
Ventricular Myocytes ◽  
Opioid Peptide ◽  
Heart Cells ◽  
Beta Adrenergic ◽  
Inotropic Effects ◽  
Intracellular Signaling Pathway ◽  
Peptide Receptor ◽  
Cyclic Monophosphate ◽  
Adrenergic Effects

Opioid peptide receptor (OPR) agonists are co-released with the beta-adrenergic receptor (beta-AR) agonist norepinephrine (NE) from nerve terminals in the heart during sympathetic stimulation. Whereas recent studies indicate that OPR and beta-AR coexist on the surface of cardiac myocytes, whether significant "cross talk" occurs between OPR and beta-AR signaling cascades within heart cells is unknown. In the present study we demonstrate a marked effect of delta-OPR stimulation to modulate beta-adrenergic responses in single isolated rat ventricular myocytes. Nanomolar concentrations (10(-8) M) of the OPR agonist leucine enkephalin (LE), a naturally occurring delta-opioid peptide, inhibited NE-induced increases in sarcolemmal L-type Ca2+ current, cytosolic Ca2+ transient, and contraction. The antiadrenergic effect of LE was pertussis toxin sensitive and abolished by naloxone, an opioid receptor antagonist. In contrast, LE was unable to inhibit the positive inotropic effects induced by equipotent concentrations of 8-(4 chlorophenylthio)-adenosine 3',5'-cyclic monophosphate, a cell-permeant adenosine 3',5'-cyclic monophosphate analog, or by the non-receptor-induced increase in contraction by elevated bathing Ca2+ concentration. These results indicate that an interaction of the OPR and beta-AR systems occurs proximal to activation of the adenosine 3',5'-cyclic monophosphate-dependent protein kinase of the beta-AR intracellular signaling pathway. This modulation of beta-adrenergic effects by OPR activation at the myocyte level may have important implications in the regulation of cardiac Ca2+ metabolism and contractility, particularly during the myocardial response to stress.

The Hemodynamic and Adrenergic Effects of Perioperative Dexmedetomidine Infusion after Vascular Surgery

2000 ◽  
Vol 90 (4) ◽  
pp. 834-839 ◽  
Author(s):  
Pekka Talke ◽  
Richard Chen ◽  
Brian Thomas ◽  
Anil Aggarwall ◽  
Alexandru Gottlieb ◽  
...  
Keyword(s):  
Vascular Surgery ◽  
Dexmedetomidine Infusion ◽  
Adrenergic Effects

Abuse of Combination Stimulants

1986 ◽  
Vol 7 (8) ◽  
pp. 234-254
Keyword(s):  
Weight Loss ◽  
Ventricular Tachycardia ◽  
Drug Abuse ◽  
Cerebral Hemorrhage ◽  
Ventricular Arrhythmias ◽  
Over The Counter ◽  
Adrenergic Effects

Over-the-counter preparations for weight loss have become very popular in this country during the last several years. Most of these preparations are combination stimulants containing phenylpropanolamine, ephedrine, and caffeine. They are widely advertised, readily available, and have become a major item for adolescent drug abuse. All of these substances have potent and direct adrenergic effects and catecholamine-releasing actions. Hypertension, cerebral hemorrhage, and psychosis have all been associated with use of phenylpropanolamine. Caffeine has been reported to cause ventricular arrhythmias, including ventricular tachycardia. There is a possibility that simultaneous ingestion of all of these drugs could increase the risk of toxicity from each. Propanolol is the treatment of choice for toxicity manifested by moderate symptomatic hypertension plus atrial or ventricular arrhythmias.

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