scholarly journals .BETA.-Adrenergic effects on salivary glands: Growth and gene regulation.

1990 ◽  
Vol 23 (2) ◽  
pp. 245-255 ◽  
Author(s):  
Setsuya Fujita ◽  
Tsukasa Ashihara ◽  
TIBOR BARKA
Keyword(s):  
Gene Regulation ◽  
Salivary Glands ◽  
Beta Adrenergic ◽  
Adrenergic Effects

Opioid peptide receptor stimulation reverses beta-adrenergic effects in rat heart cells

1997 ◽  
Vol 272 (2) ◽  
pp. H797-H805 ◽  
Author(s):  
R. P. Xiao ◽  
S. Pepe ◽  
H. A. Spurgeon ◽  
M. C. Capogrossi ◽  
E. G. Lakatta
Keyword(s):  
Intracellular Signaling ◽  
Ventricular Myocytes ◽  
Opioid Peptide ◽  
Heart Cells ◽  
Beta Adrenergic ◽  
Inotropic Effects ◽  
Intracellular Signaling Pathway ◽  
Peptide Receptor ◽  
Cyclic Monophosphate ◽  
Adrenergic Effects

Opioid peptide receptor (OPR) agonists are co-released with the beta-adrenergic receptor (beta-AR) agonist norepinephrine (NE) from nerve terminals in the heart during sympathetic stimulation. Whereas recent studies indicate that OPR and beta-AR coexist on the surface of cardiac myocytes, whether significant "cross talk" occurs between OPR and beta-AR signaling cascades within heart cells is unknown. In the present study we demonstrate a marked effect of delta-OPR stimulation to modulate beta-adrenergic responses in single isolated rat ventricular myocytes. Nanomolar concentrations (10(-8) M) of the OPR agonist leucine enkephalin (LE), a naturally occurring delta-opioid peptide, inhibited NE-induced increases in sarcolemmal L-type Ca2+ current, cytosolic Ca2+ transient, and contraction. The antiadrenergic effect of LE was pertussis toxin sensitive and abolished by naloxone, an opioid receptor antagonist. In contrast, LE was unable to inhibit the positive inotropic effects induced by equipotent concentrations of 8-(4 chlorophenylthio)-adenosine 3',5'-cyclic monophosphate, a cell-permeant adenosine 3',5'-cyclic monophosphate analog, or by the non-receptor-induced increase in contraction by elevated bathing Ca2+ concentration. These results indicate that an interaction of the OPR and beta-AR systems occurs proximal to activation of the adenosine 3',5'-cyclic monophosphate-dependent protein kinase of the beta-AR intracellular signaling pathway. This modulation of beta-adrenergic effects by OPR activation at the myocyte level may have important implications in the regulation of cardiac Ca2+ metabolism and contractility, particularly during the myocardial response to stress.

Downregulation of beta-adrenergic receptors and signal transduction response in salivary glands of NOD mice

1994 ◽  
Vol 266 (3) ◽  
pp. G433-G443
Author(s):  
Y. Hu ◽  
K. R. Purushotham ◽  
P. Wang ◽  
R. Dawson ◽  
M. G. Humphreys-Beher
Keyword(s):  
Salivary Glands ◽  
Adrenergic Receptor ◽  
Radioligand Binding ◽  
Nod Mice ◽  
Exocrine Function ◽  
Beta Adrenergic ◽  
Beta Adrenoceptor ◽  
Stimulus Response ◽  
Adrenoceptor Agonist ◽  
Second Messenger Signaling

The nonobese diabetic (NOD) mouse is subject to autoimmune disease-associated lymphocytic attack on the salivary glands with a corresponding loss of exocrine function. Downregulation of stimulus response to the beta-adrenoceptor agonist, isoproterenol, appears to be related to a decline in beta-adrenergic receptor density, changes in the level of intracellular second messenger signaling component adenosine 3',5'-cyclic monophosphate, and protein kinase A activity. An autoantibody to the beta 1-adrenergic receptor present in the sera of diabetic NOD mice may be involved in the reduced agonist response by virtue of its ability to retard dihydroalprenolol radioligand binding to receptors in the membranes of salivary glands from control mice and recognition of purified beta 1-adrenergic receptor by immunoblotting techniques.

beta-Adrenergic dilator effects in consecutive vascular sections of skeletal muscle

1982 ◽  
Vol 243 (5) ◽  
pp. H819-H829
Author(s):  
J. Lundvall ◽  
J. Hillman ◽  
D. Gustafsson
Keyword(s):  
Skeletal Muscle ◽  
Beta Adrenergic ◽  
Resistance Function ◽  
Vasoconstrictor Response ◽  
Resistance Vessels ◽  
Capillary Exchange ◽  
Regional Vascular Resistance ◽  
Hydrodynamic Exchange ◽  
Exchange Function ◽  
Adrenergic Effects

Humoral and neurogenic beta-adrenergic dilatation that influenced the resistance function, the capillary exchange function, and to some extent the capacitance function was demonstrated in the vascular bed of cat skeletal muscle. The beta-adrenergic effects were mainly confined to the microcirculation, causing dilatation of the precapillary sphincters and the resistance vessels of small calibre. The microcirculatory effects were pronounced in response to epinephrine, but blood-borne and nerve-released norepinephrine also evoked marked effects. The beta-adrenergic inhibition of vascular tone in the microcirculation may serve in the intact organism to improve tissue nutrition by facilitating capillary diffusion exchange. It further seems to regulate transcapillary hydrodynamic exchange, partly by controlling the precapillary sphincters and the capillary hydrostatic pressure. The blood-borne catecholamines, especially epinephrine, also markedly affected total regional vascular resistance and thereby blood flow by dilator interaction with the concomitant alpha-adrenergic vasoconstrictor response.

Beta-adrenergic effects on cellular cholesterologenesis and low density lipoprotein metabolism

1991 ◽  
Vol 19 (1) ◽  
pp. 41S-41S
Author(s):  
DAPHNE OWENS ◽  
LUKE O'DONNELL ◽  
PATRICK COLLINS ◽  
ALAN JOHNSON ◽  
GERALD H. TOMKIN
Keyword(s):  
Low Density Lipoprotein ◽  
Lipoprotein Metabolism ◽  
Density Lipoprotein ◽  
Low Density ◽  
Beta Adrenergic ◽  
Adrenergic Effects

Effects of beta-adrenergic agonists on splanchnic vascular volume and cardiac output

1991 ◽  
Vol 261 (5) ◽  
pp. H1499-H1507 ◽  
Author(s):  
P. I. Chang ◽  
D. L. Rutlen
Keyword(s):  
Cardiac Output ◽  
Adrenergic Agonists ◽  
Beta Adrenergic ◽  
Splenic Volume ◽  
Alpha Adrenoceptor ◽  
Beta Adrenergic Agonists ◽  
Anesthetized Dogs ◽  
Beta 2 ◽  
Beta Adrenergic Agonist ◽  
Adrenergic Effects

The effect of beta-adrenergic agonists on splanchnic intravascular volume (SIV), measured with radionuclide imaging, and the subsequent influence of such volume changes on cardiac output (CO) were examined in 40 anesthetized dogs. Isoproterenol (6 micrograms/min) caused a decrease in total SIV of 12 +/- 1% (P less than 0.001). The decrease was due entirely to a decrease in splenic volume of 24 +/- 3% (P less than 0.001), since volume increased in the remainder of the splanchnic vasculature [hepatic and mesenteric volume increased 12 +/- 2% (P less than 0.001) and 11 +/- 3% (P less than 0.02), respectively]. CO increased from 1,724 +/- 187 to 3,138 +/- 321 ml/min (P less than 0.001); after subsequent splenectomy, isoproterenol caused a similar increment. Isoproterenol-associated SIV changes were not altered by carotid denervation and vagotomy or by beta 1-adrenergic inhibition with metoprolol but were abolished by nonselective beta-adrenergic inhibition with propranolol. With a larger dose of metoprolol and smaller dose of isoproterenol to minimize beta 1-adrenergic effects, the isoproterenol-associated CO increment was attenuated (P less than 0.01) by splenectomy. With the beta 2-agonist terbutaline (41 micrograms/min) after metoprolol, total SIV decreased 15 +/- 4% (P less than 0.001). After subsequent alpha-adrenergic inhibition with phenoxybenzamine, terbutaline caused no change in SIV and an attenuated (P less than 0.05) increase in CO. Thus beta-adrenergic agonist administration causes a decrease in total SIV due entirely to a decrease in splenic volume. The SIV decrement is dependent on beta 2- and alpha-adrenoceptor stimulation and appears to enhance CO only if beta 1-adrenergic effects are minimized.

Adrenergic Effects on Secretion of Amylase from the Rat Salivary Glands

Digestion ◽  
1988 ◽  
Vol 41 (1) ◽  
pp. 34-38 ◽  
Author(s):  
Peter Skov Olsen ◽  
Preben Kirkegaard ◽  
Torben Rasmussen ◽  
Erik Magid ◽  
Steen Seier Poulsen ◽  
...  
Keyword(s):  
Salivary Glands ◽  
Rat Salivary Glands ◽  
Adrenergic Effects

scholarly journals Alpha and beta adrenergic effects on human atrial specialized conducting fibers.

Circulation ◽  
1978 ◽  
Vol 57 (1) ◽  
pp. 84-90 ◽  
Author(s):  
L Mary-Rabine ◽  
A J Hordof ◽  
F O Bowman ◽  
J R Malm ◽  
M R Rosen
Keyword(s):  
Beta Adrenergic ◽  
Adrenergic Effects

Alpha and Beta adrenergic effects on metabolism in contracting, perfused muscle

1982 ◽  
Vol 116 (3) ◽  
pp. 215-222 ◽  
Author(s):  
ERIK A. RICHTER ◽  
NEIL B. RUDERMAN ◽  
HENRIK GALBO
Keyword(s):  
Beta Adrenergic ◽  
Adrenergic Effects
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