scholarly journals Effects of Immobilization Stress on Serotonin Release in Rat Brain as Determined by in vivo Microdialysis

1992 ◽  
Vol 46 (1) ◽  
pp. 319-328
Author(s):  
Yuji Amano
Keyword(s):  
Rat Brain ◽  
Immobilization Stress ◽  
In Vivo Microdialysis ◽  
Serotonin Release

scholarly journals Effects of atropine and mecamylamine on nicotine-induced dopamine and serotonin release from striatum of rat brain by in vivo microdialysis.

1994 ◽  
Vol 64 ◽  
pp. 234
Author(s):  
Kiyofumi Itoh ◽  
Hiroyuki Konya ◽  
Hiroshi Masuda ◽  
Eizo Kakishita ◽  
Naoko Hayashi ◽  
...  
Keyword(s):  
Rat Brain ◽  
In Vivo Microdialysis ◽  
Serotonin Release

scholarly journals EFFECT OF ANOXIA ON STRIATAL MONOAMINE METABOLISM IN IMMATURE RAT BRAIN COMPARED WITH THAT OF HYPOXIA : AN IN VIVO MICRODIALYSIS STUDY† 1378

1996 ◽  
Vol 39 ◽  
pp. 232-232
Author(s):  
Wako Nakajima ◽  
Akira Ishida ◽  
Hirokazu Arai ◽  
Yasushi Takahashi ◽  
Tadahiko Ito ◽  
...  
Keyword(s):  
Rat Brain ◽  
In Vivo Microdialysis ◽  
Monoamine Metabolism ◽  
Immature Rat ◽  
Microdialysis Study

Autoreceptor-mediated Control of Serotonin Release in the Rat Brain in vivo

1991 ◽  
pp. 75-78 ◽  
Author(s):  
B. Scatton ◽  
L. Rouquier ◽  
G. Bonvento ◽  
A. Serrano ◽  
P. Blier
Keyword(s):  
Rat Brain ◽  
Serotonin Release

scholarly journals Effects of T-82 on acetylcholine and serotonin contents in the rat brain by in vivo microdialysis.

1999 ◽  
Vol 79 ◽  
pp. 255
Author(s):  
Masago Ishikawa ◽  
Kazuo Isomae ◽  
Megumi Ohta ◽  
Yoichiro Ogawa ◽  
Hiroshi Hasegawa ◽  
...  
Keyword(s):  
Rat Brain ◽  
In Vivo Microdialysis

scholarly journals (R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

2019 ◽  
Vol 22 (10) ◽  
pp. 665-674 ◽  
Author(s):  
Yukio Ago ◽  
Wataru Tanabe ◽  
Momoko Higuchi ◽  
Shinji Tsukada ◽  
Tatsunori Tanaka ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ampa Receptor ◽  
Dopamine Release ◽  
Molecular Mechanisms ◽  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Dependent Manner ◽  
Independent Mechanism ◽  
Dose Dependent

Abstract Background Although recent studies provide insight into the molecular mechanisms of the effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their metabolites is not fully understood. In view of the involvement of mechanisms other than the N-methyl-D-aspartate receptor in ketamine’s action, we investigated the effects of (R)-ketamine, (S)-ketamine, (R)-norketamine [(R)-NK], (S)-NK, (2R,6R)-hydroxynorketamine [(2R,6R)-HNK], and (2S,6S)-HNK on monoaminergic neurotransmission in the prefrontal cortex of mice. Methods The extracellular monoamine levels in the prefrontal cortex were measured by in vivo microdialysis. Results (R)-Ketamine and (S)-ketamine acutely increased serotonin release in a dose-dependent manner, and the effect of (R)-ketamine was greater than that of (S)-ketamine. In contrast, (S)-ketamine caused a robust increase in dopamine release compared with (R)-ketamine. Both ketamine enantiomers increased noradrenaline release, but these effects did not differ. (2R,6R)-HNK caused a slight but significant increase in serotonin and noradrenaline but not dopamine release. (S)-NK increased dopamine and noradrenaline but not serotonin release. Differential effects between (R)-ketamine and (S)-ketamine were also observed in a lipopolysaccharide-induced model of depression. An α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, 2,3-dioxo-6-nitro-1,2,3,4- tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX), attenuated (S)-ketamine-induced, but not (R)-ketamine-induced serotonin release, whereas NBQX blocked dopamine release induced by both enantiomers. Local application of (R)-ketamine into the prefrontal cortex caused a greater increase in prefrontal serotonin release than that of (S)-ketamine. Conclusions (R)-Ketamine strongly activates the prefrontal serotonergic system through an AMPA receptor-independent mechanism. (S)-Ketamine-induced serotonin and dopamine release was AMPA receptor-dependent. These findings provide a neurochemical basis for the underlying pharmacological differences between ketamine enantiomers and their metabolites.

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