Diurnal Variation in 5-Hydroxyindole-Acetic Acid Output in the Suprachiasmatic Region of the Siberian Hamster Assessed by in vivo Microdialysis: Evidence for Nocturnal Activation of Serotonin Release

1992 ◽  
Vol 56 (4) ◽  
pp. 582-590 ◽  
Author(s):  
J. David Glass ◽  
Walter W. Randolph ◽  
Suzie A. Ferreira ◽  
Michael A. Rea ◽  
Ursula E. Hauser ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Diurnal Variation ◽  
Acid Output ◽  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Siberian Hamster

scholarly journals (R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

2019 ◽  
Vol 22 (10) ◽  
pp. 665-674 ◽  
Author(s):  
Yukio Ago ◽  
Wataru Tanabe ◽  
Momoko Higuchi ◽  
Shinji Tsukada ◽  
Tatsunori Tanaka ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Ampa Receptor ◽  
Dopamine Release ◽  
Molecular Mechanisms ◽  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Dependent Manner ◽  
Independent Mechanism ◽  
Dose Dependent

Abstract Background Although recent studies provide insight into the molecular mechanisms of the effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their metabolites is not fully understood. In view of the involvement of mechanisms other than the N-methyl-D-aspartate receptor in ketamine’s action, we investigated the effects of (R)-ketamine, (S)-ketamine, (R)-norketamine [(R)-NK], (S)-NK, (2R,6R)-hydroxynorketamine [(2R,6R)-HNK], and (2S,6S)-HNK on monoaminergic neurotransmission in the prefrontal cortex of mice. Methods The extracellular monoamine levels in the prefrontal cortex were measured by in vivo microdialysis. Results (R)-Ketamine and (S)-ketamine acutely increased serotonin release in a dose-dependent manner, and the effect of (R)-ketamine was greater than that of (S)-ketamine. In contrast, (S)-ketamine caused a robust increase in dopamine release compared with (R)-ketamine. Both ketamine enantiomers increased noradrenaline release, but these effects did not differ. (2R,6R)-HNK caused a slight but significant increase in serotonin and noradrenaline but not dopamine release. (S)-NK increased dopamine and noradrenaline but not serotonin release. Differential effects between (R)-ketamine and (S)-ketamine were also observed in a lipopolysaccharide-induced model of depression. An α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist, 2,3-dioxo-6-nitro-1,2,3,4- tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX), attenuated (S)-ketamine-induced, but not (R)-ketamine-induced serotonin release, whereas NBQX blocked dopamine release induced by both enantiomers. Local application of (R)-ketamine into the prefrontal cortex caused a greater increase in prefrontal serotonin release than that of (S)-ketamine. Conclusions (R)-Ketamine strongly activates the prefrontal serotonergic system through an AMPA receptor-independent mechanism. (S)-Ketamine-induced serotonin and dopamine release was AMPA receptor-dependent. These findings provide a neurochemical basis for the underlying pharmacological differences between ketamine enantiomers and their metabolites.

Serotonin release in the caudal nidopallium of adult laying hens genetically selected for high and low feather pecking behavior: An in vivo microdialysis study

2014 ◽  
Vol 268 ◽  
pp. 81-87 ◽  
Author(s):  
Marjolein S. Kops ◽  
Joergen B. Kjaer ◽  
Onur Güntürkün ◽  
Koen G.C. Westphal ◽  
Gerdien A.H. Korte-Bouws ◽  
...  
Keyword(s):  
Laying Hens ◽  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Feather Pecking ◽  
Microdialysis Study

Functional regulation by dopamine receptors of serotonin release from the rat hippocampus: in vivo microdialysis study

1996 ◽  
Vol 353 (6) ◽  
pp. 621-629 ◽  
Author(s):  
Machiko Matsumoto ◽  
Mitsuhiro Yoshioka ◽  
Hiroko Togashi ◽  
Toshiya Ikeda ◽  
Hideya Saito
Keyword(s):  
Dopamine Receptors ◽  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Rat Hippocampus ◽  
Functional Regulation ◽  
Microdialysis Study

scholarly journals Acute Effects of Pyrethroids on Serotonin Release in the Striatum of Awake Rats: An In Vivo Microdialysis Study

2012 ◽  
Vol 27 (2) ◽  
pp. 150-156 ◽  
Author(s):  
Muhammad M. Hossain ◽  
Tadahiko Suzuki ◽  
Jason R. Richardson ◽  
Haruo Kobayashi
Keyword(s):  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Acute Effects ◽  
Microdialysis Study ◽  
Awake Rats

In Vivo Assessment of the Midbrain Raphe Nuclear Regulation of Serotonin Release in the Hamster Suprachiasmatic Nucleus

1999 ◽  
Vol 81 (4) ◽  
pp. 1469-1477 ◽  
Author(s):  
Thomas E. Dudley ◽  
Lisa A. Dinardo ◽  
J. David Glass
Keyword(s):  
Suprachiasmatic Nucleus ◽  
In Vivo Microdialysis ◽  
Serotonin Release ◽  
Significant Inhibition ◽  
Serotonergic Activity ◽  
Way 100635 ◽  
Drug Actions ◽  
In Vivo Assessment ◽  
Stimulation Of

In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. Serotonin (5-HT) plays important regulatory roles in mammalian circadian timekeeping; however, little is known concerning the regulation of serotonergic activity in the circadian clock located in the suprachiasmatic nuclei (SCN). By using in vivo microdialysis to measure 5-HT release we demonstrated that electrical or pharmacological stimulations of the dorsal or median raphe nuclei (DRN and MRN, respectively) can alter basal release of 5-HT in the hamster SCN. There were similar increases in SCN 5-HT release after electrical stimulation of either the MRN or DRN, indicating that both could contribute to the serotonergic activity in the SCN. Systemic pretreatment with the 5-HT antagonist metergoline abolished DRN-induced SCN 5-HT release but had little effect on MRN-induced SCN 5-HT release, suggesting different pathways for these nuclei in regulating 5-HT output in the SCN. Microinjections of the 5-HT1A autoreceptor agonist 8-OH-DPAT or antagonist WAY 100635 into the MRN caused significant inhibition and stimulation of SCN 5-HT release, respectively. Both drugs had substantially less effect in the DRN. These differential drug actions indicate that somatodendritic 5-HT1A autoreceptors on MRN neurons provide the prominent raphe autoregulation of 5-HT output in the SCN. Collectively the current results are evidence that DRN as well as MRN neurons can contribute to the regulation of 5-HT release in the hamster SCN. On the basis of the current observations and those from recent anatomic tracing studies of serotonergic projections to SCN it is hypothesized that DRN input to the SCN could be mediated by a DRN → MRN → SCN pathway involving a 5-HT–sensitive multisynaptic interaction between the DRN and MRN neurons.

Psychological stress increases serotonin release in the rat amygdala and prefrontal cortex assessed by in vivo microdialysis

1993 ◽  
Vol 162 (1-2) ◽  
pp. 81-84 ◽  
Author(s):  
Hiroshi Kawahara ◽  
Masami Yoshida ◽  
Hideyasu Yokoo ◽  
Masakatsu Nishi ◽  
Masatoshi Tanaka
Keyword(s):  
Prefrontal Cortex ◽  
Psychological Stress ◽  
In Vivo Microdialysis ◽  
Serotonin Release
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