scholarly journals Experimental Studies on the Healing Process of Wounds Following Vital Pulpotomy of Deciduous Teeth

1986 ◽  
Vol 40 (5) ◽  
pp. 911-933
Author(s):  
Hideo Ohno
Keyword(s):  
Healing Process ◽  
Experimental Studies ◽  
Deciduous Teeth

The Impact of Bedside Technology on Patients' Well-Being

2011 ◽  
Vol 5 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Karin Tanja-Dijkstra
Keyword(s):  
Medical Equipment ◽  
Emotional State ◽  
Healing Process ◽  
Experimental Studies ◽  
Well Being ◽  
Single Factor ◽  
Healthcare Design ◽  
Healthcare Environment ◽  
The Impact ◽  
Insight Into

Objective: This paper presents a study to gain insight into the effects of the visibility of medical equipment on the well-being of patients. Background: Encounters with healthcare situations are characterized by stress and anxiety. The presence of wires, tubes, and monitors near the bedside may contribute to these feelings. One of the trends in healthcare design is to organize the headwalls of patient rooms in such a way as to reduce clutter and minimize the visibility of medical equipment, but no experimental studies are available that investigate the effects of the visibility of medical equipment in patient rooms. Methods: This experiment employed a single-factor between-subjects design (medical equipment visible vs. medical equipment out of sight) exposing participants ( n = 42) to a scenario and a picture of a hospital room. Results: Placing medical equipment out of sight leads to reduced feelings of stress in patients. This stress-reducing effect is mediated by feelings of pleasure. Placing medical equipment out of sight leads to a more positive emotional state, which in turn leads to feelings of reduced stress in patients. Moreover, placing equipment out of sight leads to people having more trust in the healthcare provider. Conclusions: The current study emphasizes the importance of the built healthcare environment and shows what role the visibility of medical equipment can play in the healing process of patients.

scholarly journals Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

2014 ◽  
Vol 54 (1-2) ◽  
pp. 1-13 ◽  
Author(s):  
Tyge Nordentoft ◽  
Hans-Christian Pommergaard ◽  
Jacob Rosenberg ◽  
Michael Patrick Achiam
Keyword(s):  
Systematic Review ◽  
Fibrin Glue ◽  
Healing Process ◽  
Gastrointestinal Surgery ◽  
Experimental Studies ◽  
Positive Influence ◽  
Qualitative Synthesis ◽  
Negative Effect ◽  
The Difference ◽  
Positive Effect

Background/Aim: Anastomotic leakage remains a frequent and serious complication in gastrointestinal surgery. In order to reduce its incidence, several clinical and experimental studies on anastomotic sealing have been performed. In a number of these studies, the sealing material has been fibrin glue (FG), and the results in individual studies have been varying. The positive effect of anastomotic sealing with FG might be due to the mechanical/physical properties, the increased healing of the anastomoses or both. The aim of this systematic review was to evaluate the existing evidence on the healing effects of FG on gastrointestinal anastomoses. Methods: PubMed, EMBASE and the Cochrane databases were searched for studies evaluating the healing process of gastrointestinal anastomoses after any kind of FG application. The search period was from 1953 to December 2013. Results: Twenty-eight studies were included in the qualitative synthesis. These studies were all experimental studies, since no human studies used histological or biochemical evaluation of healing. In 7 of the 28 studies, a positive effect of FG on healing was found, while 8 studies reported a negative effect and 11 studies found no effect. Furthermore, 2 studies reported unclear results. The difference in the study outcome was independent of the study design and the type of FG used. Conclusion: In the available studies, FG did not consistently have a positive influence on the healing of gastrointestinal anastomoses. It is consequently plausible that the positive effect of FG sealing of gastrointestinal anastomoses, if there is any, may be due to a mechanical sealing effect rather than due to improved healing per se.

scholarly journals The use of electrical stimulation to enhance spinal fusion

2002 ◽  
Vol 13 (6) ◽  
pp. 1-7 ◽  
Author(s):  
Michael A. Morone ◽  
Henry Feuer
Keyword(s):  
Electrical Stimulation ◽  
Spinal Fusion ◽  
Healing Process ◽  
Experimental Studies ◽  
Spinal Instrumentation ◽  
Fusion Rate ◽  
Beneficial Effects ◽  
Osseous Union ◽  
Spinal Segments ◽  
Spinal Arthrodesis

The goal of spinal arthrodesis is a solid osseous union across one or more spinal segments. A solid bone union after arthrodesis is commonly known as a spinal fusion. Surgeons have begun to understand the biomechanical and biological factors that influence the bone-healing process. One of the most commonly used adjuncts is spinal instrumentation. Instrumentation has increased the spinal fusion rate; however, fusion failure (that is, nonunion or pseudarthrosis) remains significant. A less commonly used adjunct is electrical stimulation (ES). Investigators in experimental studies have demonstrated the beneficial effects of ES on increasing the fusion rate. In this review the authors discuss the evidence concerning the benefits of ES as an adjunct to spinal arthrodesis. In addition, the different types of ES devices are described along with the current experimental and clinical evidence for each type of device.

scholarly journals Methods for assessment of the course of wound process

2019 ◽  
Keyword(s):  
Clinical Medicine ◽  
Objective Assessment ◽  
Bacterial Flora ◽  
Healing Process ◽  
Experimental Studies ◽  
Infectious Agent ◽  
The State ◽  
Wound Healing Process ◽  
Tissue Destruction

Summary: The article is devoted to the analysis of methods for evaluation of the course of wound process. The problem of the treatment of wounds of various etiology is one of the complex sections of clinical medicine. Currently, there is an increase in the proportion of traumatic injuries that can cause wounds. Also common are vascular diseases and endocrine pathology, associated with the development of complications with the formation of tissue defects. The presence of tissue destruction and an infectious agent in the wound determine the development of purulent-inflammatory process in it. The current direction is determination of the criteria for diagnosis and methods of prevention of general and local complications. The purpose of the study was to determine the clinical and laboratory parameters used to reveal the stage of the wound process and to predict the development of complications. The factors that determine the wound healing process and the appropriate techniques for assessing the wound process were studied. Subjective and objective methods are identified among the control methods. The article describes techniques that reflect the condition of tissues forming the wound walls or wound surface; techniques enabling to characterize bacterial flora by qualitative and quantitative indicators; methods allowing to determine the state of local and general body resistance. A brief description of standard techniques – cytological examination of wound exudate, assessment of cytograms, planimetric and bacteriological tests – is given. The data on determination of pH of wound medium and liquid volumetric vulnerometry, estimation of the state of granulation tissue are given. The value of the use of computerized diagnostics and computerized monitoring of the wound process was studied. The importance of methods for objective assessment of the course of the wound process for control of the treatment efficacy and in experimental studies during preclinical trials of medicinal products and medical devices has been demonstrated.

scholarly journals Composite Wound Dressing Based on Chitin/Chitosan Nanofibers: Processing and Biomedical Applications

Cosmetics ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 16 ◽  
Author(s):  
Anton Shabunin ◽  
Vladimir Yudin ◽  
Irina Dobrovolskaya ◽  
Evgeny Zinovyev ◽  
Viktor Zubov ◽  
...  
Keyword(s):  
Wound Dressing ◽  
High Efficiency ◽  
Healing Process ◽  
Experimental Studies ◽  
Scar Tissue ◽  
Wound Dressings ◽  
Control Group ◽  
Wound Healing Process ◽  
Electrospinning Technique

An electrospinning technique was used for the preparation of a bilayered wound dressing consisting of a layer of aliphatic copolyamide nanofibers and a layer of composite nanofibers from chitosan and chitin nanofibrils filler. Processed dressings were compared with aliphatic copolyamide nanofiber-based wound dressings and control groups. Experimental studies (in vivo treatment of third-degree burns with this dressing) demonstrated that almost complete (up to 97.8%) epithelialization of the wound surface had been achieved within 28 days. Planimetric assessment demonstrated a significant acceleration of the wound healing process. Histological analysis of scar tissue indicated the presence of a significant number of microvessels and a low number of infiltrate cells. In the target group, there were no deaths or purulent complications, whereas in the control group these occurred in 25% and 59.7% of cases, respectively—and, in the copolyamide group, 0% and 11%, respectively. The obtained data show the high efficiency of application of the developed composite chitosan‒copolyamide wound dressings for the treatment of burn wounds.

High-density lipoprotein therapy inhibits Porphyromonas gingivalis-induced abdominal aortic aneurysm progression

2016 ◽  
Vol 115 (04) ◽  
pp. 789-799 ◽  
Author(s):  
Martin Rouer ◽  
Jean-Marc Alsac ◽  
Liliane Louedec ◽  
Faisal Al Shoukr ◽  
Francois Rouzet ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Healing Process ◽  
Experimental Studies ◽  
High Density ◽  
Aortic Aneurysms ◽  
High Density Lipoproteins ◽  
Sprague Dawley ◽  
Healthy Human ◽  
Potential Implication ◽  
Abdominal Aortic

SummaryClinical and experimental studies have highlighted the potential implication of periondontal bacteria contamination in the pathogenesis of abdominal aortic aneurysms (AAA). In addition to their role in reverse cholesterol transport, high-density lipoproteins (HDLs) display multiple functions, including anti-inflammatory and lipopolysaccharide scavenging properties. Low plasma levels of HDL-cholesterol have been reported in AAA patients. We tested the effect of a HDL therapy in Sprague-Dawley rat model of AAA, obtained by intraluminal elastase infusion followed by repeated injections of Porphyromonas gingivalis (Pg). HDLs, isolated by ultracentrifugation of plasma from healthy human volunteers, were co-injected intravenously (10 mg/kg) with Pg (1.107 Colony Forming Unit) one, eight and 15 days after elastase perfusion. Rats were sacrificed one week after the last injection. Our results show that Pg injections promote the formation of a persistent neutrophil-rich thrombus associated with increased aortic diameter in this AAA model. HDLs significantly reduced the increased AAA diameter induced by Pg. Histology showed the onset of a healing process in the Pg/HDL group. HDL injections also reduced neutrophil activation in Pg-injected rats associated with decreased cytokine levels in conditioned media and plasma. Scintigraphic analysis showed an intense uptake of 99mTc-HDL by the AAA suggesting that HDLs could exert their beneficial effect by acting directly on the thrombus components. HDL supplementation may therefore constitute a new therapeutic tool for AAA treatment.Supplementary Material to this article is available online at www.thrombosis-online.com.

Bioartificial bone grafting:Tarsal joint fusion in a dog using a bioartificial composite bone graft consisting of β-tricalciumphosphate and platelet rich plasma – A case report

2005 ◽  
Vol 18 (01) ◽  
pp. 52-54 ◽  
Author(s):  
H.-A. Merten ◽  
A. Bader ◽  
G. Uhr ◽  
A. Deivick ◽  
A. Meyer-Lindenberg ◽  
...  
Keyword(s):  
Bone Graft ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Tumor Resection ◽  
Experimental Studies ◽  
Tarsal Joint ◽  
Intertarsal Joint ◽  
The Right ◽  
Large Bone ◽  
Large Bone Defects

SummaryGrafting of large bone defects caused by trauma or tumor resection still remains a problem to solve. In experimental studies as well as in human dentistry, osteoconduction and biodegradation of the β-tricalciumphosphate Cerasorb® as well as osteoinductive capabilities of platelet rich plasma have been proven. In case of luxation of the right tarsal joint, including a compressive fracture of the forth tarsal bone, the recommended use of autologous cancellous bone to support osseous fusion was replaced by the use of a bioartificial bone graft. Biodegradation of the bone graft was proven clinically and radiographically. Complete osseous fusion of the intertarsal joint occurred. The use of the β-tricalciumphosphate Cerasorb in combination with platelet rich plasma to support a partial arthrodesis of the tarsal joint in a dog did not impede the healing process but led to full recovery of the patient, indicating that this concept of bioartificial bone grafting could support bone healing.

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