Histopathological Studies on the Healing Process of Wounds Following Pulpotomy of Deciduous Teeth : Focused on Formocresol

BACKGROUND: Burn injuries are one of the major health problems all over the world. The problem of infection in burn wounds is considered a major problem and the main cause of death in many burned patients. Ozone has been used with good results in the treatment of patients with diabetic foot, because of its germicidal properties and its influence on the processes of oxygen metabolism, and other effects. PURPOSE: We report the effect of Ozone therapy on the healing process of recent burns in the Burn unit of the Alexandria Main University Hospital and Plastic Surgery Department Faculty of Medicine, Alexandria University. Patients and methods: A review of two RCTs of 140 patients with recent burns done to investigate the effects of topical application of ozonized water, ozone gas (Sauna or Bagging), and ozonized olive oil in the treatment of recent burns. RESULTS: All patients manifested clinical improvement by Topical Ozone therapy. The healing time of the ozone treated wounds was significantly lower than that of the control wounds. The full-thickness infected necrotic wounds that were treated with ozone showed earlier clearance of necrotic tissue and infection than the control wounds and became ready for skin grafting in a significantly lower time than the control wounds. Histopathological studies revealed marked increase in the expression of the fibronectin and transforming growth factor-B after treatment in comparison to the control wounds. CONCLUSION: Topical application of ozone causes a highly significant reduction in the healing time of the recent burn injuries.

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EFFECT OF SITAGLIPTIN AND VILDAGLIPTIN ON WOUND HEALING IN MALE WISTAR RATS - AN EXPERIMENTAL STUDY

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i8.26061 ◽

2018 ◽

Vol 11 (8) ◽

pp. 392

Author(s):

Netravathi B Angadi ◽

Urmila Kagal ◽

Somaling Timshetti

Keyword(s):

Wound Healing ◽

Granulation Tissue ◽

Dead Space ◽

Wistar Rats ◽

Healing Process ◽

Dry Weight ◽

Morbidity And Mortality ◽

Wound Model ◽

Male Wistar Rats ◽

Histopathological Studies

Objective: Diabetes mellitus (DM) is a spectrum of common metabolic disorders, arising from a variety of pathogenic mechanisms. With an increasing incidence worldwide, DM will be likely a leading cause of morbidity and mortality in the future. Delayed wound healing in diabetes is a major source of morbidity and mortality. Sitagliptin and Vildagliptin are novel antihyperglycemic agents used for the treatment of DM. The present study was planned to investigate the effect of Sitagliptin and Vildagliptin on various wound healing models in male Wistar rats.Methods: Male Wistar rats (150–200 g) were divided into three groups, i.e., control, Sitagliptin, and Vildagliptin (n=6 animals in each group) for each wound model. Excision wound, resutured incision wound, and dead space wounds were inflicted under thiopentone anesthesia in male Wistar rats. The rats received Sitagliptin and Vildagliptin orally during the study period. Resutured incision was assessed by wound breaking strength; dead space wound was assessed by granuloma dry weight and histopathology of granulation tissue. In excision wounds, treatment was monitored by planimetry. Data were expressed as mean±standard error of mean and analyzed by analysis of variance followed by Dunnett’s post hoc test. p<0.05 was considered statistically significant.Results: Sitagliptin and Vildagliptin significantly promoted the healing process in all three wound models studied. Histopathological studies revealed increased collagen content and granulation tissue in Sitagliptin and Vildagliptin groups.Conclusion: In all the three wound models studied, Sitagliptin and Vildagliptin promoted wound healing. The pro-healing effect of Sitagliptin and Vildagliptin needs to be explored clinically.

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