scholarly journals Nasal Mucosal Melanosis may act as a Harbinger of Melanoma: A Case Report

2016 ◽  
Vol 7 (3) ◽  
pp. ar.2016.7.0174 ◽  
Author(s):  
William C. Yao ◽  
Kevin S. Emerick ◽  
Stefan Kraft ◽  
Eric H. Holbrook
Keyword(s):  
Case Report ◽  
Nasal Cavity ◽  
Cutaneous Melanoma ◽  
Precancerous Lesion ◽  
Melanoma In Situ ◽  
Pigmented Lesion ◽  
Endoscopic Observation ◽  
Mucosal Lesions ◽  
Over Time

Background The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions. However, to our knowledge, there has never been documentation of melanosis transforming into melanoma over time. Objective To describe a transformation of a mucosal melanosis into melanoma. Methods A 53-year-old man with diffuse melanosis of the nasal cavity underwent surgical resection. Results Pathology revealed melanocytic hyperplasia without evidence of melanoma. The patient was serially examined, with excisions for new areas of melanosis. The pathology progressed to severely atypical melanocytic proliferation and melanoma in situ over a 4-year period. Conclusion Nasal melanosis may be a precancerous lesion and may transform into melanoma. All melanosis should be biopsied with close endoscopic observation. Lesions with dysplasia or atypia should be excised due to potential transformation to melanoma.

scholarly journals Micromelanomas: A Review of Melanomas≤2 mm and a Case Report

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Sharad P. Paul
Keyword(s):  
Case Report ◽  
Previous History ◽  
Melanoma In Situ ◽  
Pigmented Lesions ◽  
Pigmented Lesion ◽  
History Of

The ABCD acronym used to screen pigmented lesions for melanoma obviously was not designed to contend with melanomas that are under 2 mm in diameter. Previously, views ranged that such small lesions could not be melanomas until a few reports of such “micromelanomas” emerged. The author presents a 2 mm melanoma in situ presenting as an insignificant pigmented lesion in a 60-year-old patient with no previous history of melanoma or multiple nevi—which is usually the norm in cases of small melanoma. This paper reiterates the fact that when it comes to a melanoma, size does not matter. In this paper, the term “micromelanoma” is used by the author to represent melanomas under 2 mm. Dermatoscopy and histopathology findings are discussed in this case, along with a review of small melanomas.

In Situ and Very thin Melanomas (< 0.75 mm) are Similarly and Commonly Recognizable

1996 ◽  
Vol 82 (6) ◽  
pp. 600-602 ◽  
Author(s):  
Aldo Bono ◽  
Cesare Bartoli ◽  
Laura Tessandri ◽  
Ivan Del Prato ◽  
Gabrina Tragni ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Cutaneous Melanoma ◽  
Early Stage ◽  
Diagnostic Sensitivity ◽  
Melanoma In Situ

Aims and Background Recent data have suggested that cutaneous melanoma in situ can be clinically recognized in most cases by its features, which resemble those of early invasive melanoma. The aim of the study was to verify whether the diagnostic sensitivity of melanoma in situ is actually equivalent to that of early invasive melanoma. Methods We retrospectively reviewed the clinical diagnosis of 274 consecutive cutaneous melanoma <0.75 mm thick. The series consisted of 84 in situ and 190 invasive lesions. Results The clinical diagnosis of melanoma was performed in 62% (52/84) of cases of in situ melanoma and in 68% (130/190) of the cases of invasive melanoma. The differences were not statistically significant. Conclusions Our results show that cutaneous melanoma can be clinically diagnosed at a very early stage. In situ and very thin melanomas (< 0.75 mm) are similarly recognizable.

scholarly journals Primary Cilium Depletion Typifies Cutaneous Melanoma In Situ and Malignant Melanoma

PLoS ONE ◽  
2011 ◽  
Vol 6 (11) ◽  
pp. e27410 ◽  
Author(s):  
Jinah Kim ◽  
Salma Dabiri ◽  
E. Scott Seeley
Keyword(s):  
Malignant Melanoma ◽  
Primary Cilium ◽  
Cutaneous Melanoma ◽  
Melanoma In Situ

scholarly journals Topical treatment of recurrent vaginal melanoma in situ with imiquimod: A case report

2012 ◽  
Vol 2 (3) ◽  
pp. 92-93 ◽  
Author(s):  
Lauren S. Prescott ◽  
Nicholas E. Papadopoulos ◽  
Elizabeth D. Euscher ◽  
Jack L. Watkins ◽  
Kathleen M. Schmeler
Keyword(s):  
Case Report ◽  
Topical Treatment ◽  
Melanoma In Situ

scholarly journals Melanoma in situ colonizing basal cell carcinoma: a case report and review of the literature

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Silvia Mancebo ◽  
Michael Marchetti ◽  
Travis Hollmann ◽  
Ashfaq Marghoob ◽  
Klaus Busam ◽  
...  
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Review Of The Literature ◽  
Melanoma In Situ

Recurrent primary vulvovaginal malignant melanoma arising in melanoma in situ – the natural history of lesions followed for 23 years

2004 ◽  
Vol 14 (4) ◽  
pp. 628-632
Author(s):  
N. J. Kingston ◽  
R. W. Jones ◽  
J. Baranyai
Keyword(s):  
Malignant Melanoma ◽  
Natural History ◽  
Metastatic Melanoma ◽  
Cutaneous Melanoma ◽  
Mucosal Melanoma ◽  
Histologic Examination ◽  
Melanoma In Situ ◽  
Pigmented Lesions ◽  
History Of

Multifocal melanoma and melanoma in situ of the vulva and vagina are uncommon lesions, and our understanding of their natural history is limited. Vulvovaginal melanoma appears to be biologically different from cutaneous melanoma and has more in common with mucosal melanoma. A 60-year-old woman presented in 1977 with a pigmented vulvar lesion. Histologic examination revealed melanoma in situ associated with focal invasive melanoma. She re-presented with recurrent primary melanomas arising in melanoma in situ in 1990 and 1998 and died of widespread metastatic melanoma in 2000. Melanoma in situ of the vulva and vagina is rare and appears to have a relatively slow but definite progression to invasive melanoma. All suspicious pigmented lesions in this region should be biopsied, and if multifocal in situ melanoma is identified, vulvo(vagin)ectomy should be considered.

scholarly journals Evaluation of outpatient discharge in patients with cutaneous melanoma

2015 ◽  
Vol 42 (2) ◽  
pp. 70-74
Author(s):  
Nurimar C. Fernandes ◽  
Flauberto de Sousa Marinho
Keyword(s):  
Cutaneous Melanoma ◽  
Cross Sectional Study ◽  
The Other ◽  
Stage Iiic ◽  
Cross Sectional ◽  
Melanoma In Situ ◽  
Stage Ia ◽  
The One

OBJECTIVE: to evaluate discharge in a group of patients with cutaneous melanoma according to recently established criteria. METHODS: we conducted an observational, cross-sectional study with 32 patients at the Hospital Universitário Clementino Fraga Filho (HUCFF) / Universidade Federal do Rio de Janeiro (UFRJ), between 1995 and 2013, in the following stages: IA (17 cases, 53.12%), IB (4 cases, 12.5%), IIA (3 cases, 9.37%), IIC (1 case, 3.12%), IIIB (1 case, 3.12%), IIIC (3 cases, 9.37%), melanomas in situ (2 cases, 6.25%), Tx (1 case, 3.12%). RESULTS: the follow-up time varied from one to 20 years (stage IA), five to 15 years (stage IB), six to 17 years (stage IIA), 20 years (stage IIC), 23 years (stage IIIB) and 14 to 18 years (stage IIIC). One melanoma in situ (subungueal) was discharged in the fourth year of follow-up and the other was promptly discharged. The Tx melanoma was followed for 12 years. We observed no relapses or recurrences in the period. CONCLUSION: although a controversial issue, it was possible to endorse the discharge of the patients since our follow-up time had already exceeded the one recommended by the other authors.

Sign in / Sign up

Export Citation Format

Share Document