scholarly journals Predictors of left ventricular hypertrophy development in patients with essential hypertension: role of pro- and anti-inflammatory cytokines

2018 ◽  
Vol 2 (Issue 4) ◽  
pp. 97 ◽  
Author(s):  
Larisa Tsoi ◽  
Andrei Polupanov ◽  
Ibragim Sabirov ◽  
Tazagul Zalova ◽  
Flora Rysmatova
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Interleukin 10 ◽  
Left Ventricular ◽  
Myocardial Remodeling ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Objective: The data on the relationship between the level of TNF-α and interleukin-10 with the presence of left ventricular hypertrophy and myocardial remodeling in patients with essential hypertension is presented. Methods: Overall, 156 patients with essential hypertension aged 40 to 75 years (with mean age 55.8 ± 7.5 years) were examined; of which 57 were women and 99 were men. All patients were divided into two groups. The first group included 73 patients showing the presence of  left ventricular hypertrophy (LVH), established by echocardiography; the second group included 83 patients who showed no signs of LVH on the echocardiogram. Results: According to the study, no relationship was found between the concentration of tumor necrosis factor α (TNF-α) and the development of LVH. It was also shown that only men, but not women with, were associated with the presence of LVH with low levels of interleukin-10 ( IL-10). In addition, a negative correlation was found between the concentration of tumor necrosis factor α (TNF-α) and IL-10 with the thickness of the left ventricular walls at the initial stages of myocardial remodeling on the echocardiography. Conclusion: Thus, our study demonstrates the modulating role of inflammation on the processes of myocardial remodeling in hypertension.

scholarly journals The relationship of cytokine status with left ventricular hypertrophy in patients with arterial hypertension

2019 ◽  
Vol 100 (2) ◽  
pp. 204-213
Author(s):  
T B Zalova ◽  
A G Polupanov ◽  
L G Tsoy ◽  
F T Rysmatova ◽  
I S Sabirov
Keyword(s):  
Tumor Necrosis Factor ◽  
Left Ventricular Hypertrophy ◽  
Tumor Necrosis ◽  
Ventricular Hypertrophy ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 10 ◽  
Left Ventricular ◽  
Factor Α ◽  
Relationship Of ◽  
Necrosis Factor

Aim. To study the relationship of tumor necrosis factor α and interleukin-10 levels with the presence of left ventricular hypertrophy and myocardial remodeling in patients with arterial hypertension. Metods. 156 patients with hypertension aged 40 to 75 years (mean age 55.8±7.5 years), including 57 women and 99 men were examined. All patients were divided into two groups. Group 1 included 83 patients without left ventricular hypertrophy (55.5±7.5 years), group 2 included 73 patients with left ventricular hypertrophy (56.2±7.8 years), established by echocardiographic signs. All patients in addition to the general clinical examination and biochemical studies had echocardiography and Doppler echocardiography performed, as well as measurement of the concentration of tumor necrosis factor α and interleukin-10 by solid-phase enzyme immunoassay using specialized «Cytokine-Stimulus-Best» kit (Novosibirsk, Russia). Results. The concentration of tumor necrosis factor α in patients without left ventricular hypertrophy was 8.43±1.36 pg/ml and was comparable with the concentration of this cytokine in patients with left ventricular hypertrophy (8.54±1.58 pg/ml, p >0.05). This pattern was typical for both men and women. The concentration of interleukin-10 in both groups was also comparable (15.4±3.6 pg/ml in group 1 and 14.7±3.4 pg/ml in group 2, p >0.05). However, we identified gender-specific features in the relationship of interleukin-10 with the presence of left ventricular hypertrophy in patients with hypertension. Thus, while in women the concentration of cytokine in groups with/without left ventricular hypertrophy did not differ significantly, in men without hypertrophy the level of interleukin-10 of 15.7±3.6 pg/ml, was significantly higher than the value of the same indicator in the group of men with left ventricular hypertrophy (14.8±2.9 pg/ml, p <0.025). Multivariate regression analysis showed that tumor necrosis factor α and interleukin-10 concentrations correlated to left ventricular wall thickness in patients without left ventricular hypertrophy. No such pattern was revealed for patients with hypertrophy. Conclusion. The results demonstrate the modulating role of tumor necrosis factor α and interleukin-10 in myocardial remodeling processes in arterial hypertension.

scholarly journals Potential role of a disintegrin and metalloproteinase-17 (ADAM17) in age-associated ventricular remodeling of rats

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14321-14330 ◽  
Author(s):  
Hainiang Liu ◽  
Haoren Wang ◽  
Dong Cheng ◽  
Qinfu Wang ◽  
Zuowei Pei ◽  
...  
Keyword(s):  
Potential Role ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Myocardial Dysfunction ◽  
Left Ventricular ◽  
Tnf Α ◽  
A Disintegrin And Metalloproteinase ◽  
Factor Α ◽  
Necrosis Factor

Excessive tumor necrosis factor-α (TNF-α) could enhance cell death and aggravate left ventricular remodeling and myocardial dysfunction.

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