scholarly journals Induction of tolerance to Porphyromonas gingivalis LPS in human monocytes.

Ensho ◽  
2000 ◽  
Vol 20 (2) ◽  
pp. 147-154
Author(s):  
Hidetoshi Shimauchi ◽  
Tomohiko Ogawa ◽  
Takashi Hayashi ◽  
Kozo Okuda ◽  
Hiroshi Okada
Keyword(s):  
Porphyromonas Gingivalis ◽  
Human Monocytes ◽  
Porphyromonas Gingivalis Lps ◽  
Induction Of Tolerance

VIP Inhibits Porphyromonas gingivalis LPS-induced Immune Responses in Human Monocytes

2005 ◽  
Vol 84 (11) ◽  
pp. 999-1004 ◽  
Author(s):  
N. Foster ◽  
J. Cheetham ◽  
J.J. Taylor ◽  
P.M. Preshaw
Keyword(s):  
Immune Responses ◽  
Porphyromonas Gingivalis ◽  
Immune Cells ◽  
Nuclear Translocation ◽  
Dependent Manner ◽  
Human Monocytes ◽  
Tnf Α ◽  
Autoimmune Conditions ◽  
Porphyromonas Gingivalis Lps

Lipopolysaccharide (LPS) from the Gram-negative pathogen Porphyromonas gingivalis ( Pg) stimulates cytokine secretion in immune cells, and thereby initiates the inflammation associated with periodontitis. Modulation of pro-inflammatory cytokine activity is a plausible therapeutic target in periodontal disease. Vasoactive intestinal peptide (VIP) has a role in immunoregulation, and has been identified as a molecule with therapeutically beneficial immunosuppressive effects in inflammatory and autoimmune conditions. We aimed to investigate the effect of VIP on immune responses induced by Pg LPS in vitro. VIP (10−8 M) significantly (P < 0.05) inhibits TNF-α production by human monocytic THP1 cells stimulated with Pg LPS. In parallel, we showed that VIP inhibits nuclear translocation of NFκB and c-Jun in a time-dependent manner, but does not decrease the expression of CD14 receptors. This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes.

109. Repeated social defeat increases cytokine production by Porphyromonas gingivalis LPS-stimulated macrophages

2008 ◽  
Vol 22 (4) ◽  
pp. 34-35
Author(s):  
Michael Bailey ◽  
Steven Kinsey ◽  
Rebecca Allen ◽  
David Padgett ◽  
John Sheridan
Keyword(s):  
Porphyromonas Gingivalis ◽  
Cytokine Production ◽  
Social Defeat ◽  
Porphyromonas Gingivalis Lps

Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes

2012 ◽  
Vol 17 (4) ◽  
pp. 1279-1285 ◽  
Author(s):  
Gláucia de Camargo Pereira ◽  
Gustavo Narvaes Guimarães ◽  
Aline Cristiane Planello ◽  
Mauro Pedrine Santamaria ◽  
Ana Paula de Souza ◽  
...  
Keyword(s):  
Gene Expression ◽  
Porphyromonas Gingivalis ◽  
Hacat Keratinocytes ◽  
Expression Levels ◽  
Porphyromonas Gingivalis Lps ◽  
Gene Expression Levels

scholarly journals Induction of Lethal Shock and Tolerance by Porphyromonas gingivalis Lipopolysaccharide ind-Galactosamine-Sensitized C3H/HeJ Mice

1999 ◽  
Vol 67 (7) ◽  
pp. 3399-3402 ◽  
Author(s):  
Ken-Ichi Tanamoto
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Porphyromonas Gingivalis ◽  
Lethal Dose ◽  
Lethal Effect ◽  
Lethal Action ◽  
Lethal Toxicity ◽  
Porphyromonas Gingivalis Lipopolysaccharide ◽  
Lethal Shock ◽  
Induced Tolerance ◽  
Induction Of Tolerance

ABSTRACT Lipopolysaccharide (LPS) obtained from Porphyromonas gingivalis was found to exhibit marked lethal toxicity in galactosamine-sensitized C3H/HeJ mice. Although no lethality was observed in mice intraperitoneally challenged with 1 mg of P. gingivalis LPS without galactosamine, when they were sensitized with 30 mg of galactosamine, challenge with 1 and 10 μg of LPS resulted in 67 and 100% lethality, respectively. The lethal dose of LPS was almost the same in LPS-responsive C57BL/6 mice and non-LPS-responsive C3H/HeJ mice. Furthermore, when 1 μg of P. gingivalis LPS was administered to each mouse 90 min before the challenge with the same LPS with galactosamine, tolerance to the lethal action of LPS was induced, and the mice were completely protected from death, even at a dose 100-fold greater than the lethal dose of LPS. Neither a lethal effect nor induction of tolerance to the lethality ofP. gingivalis LPS was exhibited by SalmonellaLPS in galactosamine-sensitized C3H/HeJ mice. A protein-LPS complex derived from Pseudomonas aeruginosa, which exhibited strong lethality and induced tolerance to a subsequent challenge with a lethal dose of LPS in galactosamine-sensitized LPS-responsive mice, did not exhibit lethal toxicity in galactosamine-sensitized C3H/HeJ mice and failed to induce tolerance in these mice to the lethality of P. gingivalis LPS. These results indicate that P. gingivalis LPS plays the central role in the activation of non-LPS-responsive C3H/HeJ mice.

Porphyromonas gingivalis antagonises Campylobacter rectus induced cytokine production by human monocytes

Cytokine ◽  
2007 ◽  
Vol 39 (2) ◽  
pp. 147-156 ◽  
Author(s):  
N. Bostanci ◽  
R.P. Allaker ◽  
G.N. Belibasakis ◽  
M. Rangarajan ◽  
M.A. Curtis ◽  
...  
Keyword(s):  
Porphyromonas Gingivalis ◽  
Cytokine Production ◽  
Human Monocytes ◽  
Campylobacter Rectus
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