scholarly journals Bone resorption mechanisms of middle ear cholesteatoma. Immunohistochemical study of decalcified ossicles and biochemical study of bone-resorbing activity produced by cholesteatoma tissue in culture.

Ensho ◽  
1990 ◽  
Vol 10 (5) ◽  
pp. 355-359
Author(s):  
Atsushi Kurihara ◽  
Shuji Koike ◽  
Masaru Toshima
Keyword(s):  
Bone Resorption ◽  
Middle Ear ◽  
Immunohistochemical Study ◽  
Biochemical Study ◽  
Middle Ear Cholesteatoma ◽  
Bone Resorbing Activity

scholarly journals Animal Models of Middle Ear Cholesteatoma

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Tomomi Yamamoto-Fukuda ◽  
Haruo Takahashi ◽  
Takehiko Koji
Keyword(s):  
Hearing Loss ◽  
Bone Resorption ◽  
Animal Models ◽  
Middle Ear ◽  
Future Prospect ◽  
Pathological Condition ◽  
Current Status ◽  
Morphologic Characteristics ◽  
Middle Ear Cholesteatoma ◽  
Acquired Cholesteatoma

Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. Unfortunately, our understanding of the mechanism underlying its pathogenesis is limited. To investigate its pathogenesis, different animal models have been used. This paper provides a brief overview of the current status of research in the field of pathogenesis of middle ear acquired cholesteatoma, four types of animal models previously reported on, up-to-date cholesteatoma research using these animal models, our current studies of the local hybrid ear model, and the future prospect of new animal models of middle ear cholesteatoma.

Possible participation of acidic pH in bone resorption in middle ear cholesteatoma

2013 ◽  
Vol 124 (1) ◽  
pp. 245-250 ◽  
Author(s):  
Khac‐Hung Nguyen ◽  
Hideaki Suzuki ◽  
Toyoaki Ohbuchi ◽  
Tetsuro Wakasugi ◽  
Hiroki Koizumi ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Middle Ear ◽  
Acidic Ph ◽  
Middle Ear Cholesteatoma

Histology, Pathogenesis, and Treatment of Cholesteatoma

1984 ◽  
Vol 93 (4_suppl) ◽  
pp. 125-128 ◽  
Author(s):  
Maxwell Abramson ◽  
Hiroshi Moriyama ◽  
Cheng Chun Huang
Keyword(s):  
Animal Model ◽  
Bone Resorption ◽  
Connective Tissue ◽  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Increase Bone Resorption ◽  
Pathogenic Factors ◽  
Middle Ear Cholesteatoma

Factors present in cholesteatoma connective tissue induce bone resorption in chronic otitis media. The presence of skin and its products appears to exacerbate the destructive influence of connective tissue. One exacerbating factor is pressure, shown in an animal model to increase bone resorption by influencing the subepithelial connective tissue. Consideration of pathogenic factors provides a rationale for modifications in the treatment of middle ear cholesteatoma.

The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma

2016 ◽  
Vol 274 (5) ◽  
pp. 2071-2078 ◽  
Author(s):  
Shumin Xie ◽  
Xiaoli Wang ◽  
Jihao Ren ◽  
Wei Liu
Keyword(s):  
Bone Resorption ◽  
Middle Ear ◽  
Middle Ear Cholesteatoma

A comparison of high resolution CT scan of temporal bone and operative findings in middle ear cholesteatoma

1993 ◽  
Vol 29 (5) ◽  
pp. 896
Author(s):  
Tae Beom Kweon ◽  
Hun Seong ◽  
Mal Soon Cheon ◽  
Hack Jin Kim ◽  
Keung Jae Jang ◽  
...  
Keyword(s):  
High Resolution ◽  
Ct Scan ◽  
Temporal Bone ◽  
Middle Ear ◽  
High Resolution Ct ◽  
Middle Ear Cholesteatoma ◽  
Operative Findings

Co-purification of bone resorbing activity and adenylate cyclase stimulating activity from human tumours associated with the humoral hypercalcaemia of malignancy

1987 ◽  
Vol 114 (1) ◽  
pp. 18-26 ◽  
Author(s):  
Chohei Shigeno ◽  
Itsuo Yamamoto ◽  
Shegiharu Dokoh ◽  
Megumu Hino ◽  
Jun Aoki ◽  
...  
Keyword(s):  
Bone Resorption ◽  
High Performance ◽  
Basic Protein ◽  
Gel Filtration ◽  
Exchange Chromatography ◽  
Protein Factor ◽  
Human Tumours ◽  
Acid Stable ◽  
Bone Resorbing Activity

Abstract. We have partially purified a tumour factor capable of stimulating both bone resorption in vitro and cAMP accumulation in osteoblastic ROS 17/2 cells from three human tumours associated with humoral hypercalcaemia of malignancy. Purification of tumour factor by sequential acid urea extraction, gel filtration and cation-exchange chromatography, reverse-phase high performance liquid chromatography followed by analytical isoelectric focussing provided a basic protein (pI > 9.3) with a molecular weight of approximately 13 000 as a major component of the final preparation which retained both the two bioactivities. Bone resorbing activity and cAMP-increasing activity in purified factor correlated with each other. cAMP-increasing activity of the factor was heat- and acid-stable, but sensitive to alkaline ambient pH. Treatment with trypsin destroyed cAMP-increasing activity of the factor. Synthetic parathyroid hormone (PTH) antagonist, human PTH-(3– 34) completely inhibited the cAMP-increasing activity of the factor. The results suggest that this protein factor, having its effects on both osteoclastic and osteoblastic functions, may be involved in development of enhanced bone resorption in some patients with humoral hypercalcaemia of malignancy.

MRI of middle ear cholesteatoma: The importance of observer reliance from diffusion sequences

2021 ◽  
Author(s):  
Natalie Fischer ◽  
Michaela Plaikner ◽  
Volker H. Schartinger ◽  
Christian Kremser ◽  
Herbert Riechelmann ◽  
...  
Keyword(s):  
Middle Ear ◽  
Middle Ear Cholesteatoma
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