scholarly journals Animal Models of Middle Ear Cholesteatoma

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Tomomi Yamamoto-Fukuda ◽  
Haruo Takahashi ◽  
Takehiko Koji
Keyword(s):  
Hearing Loss ◽  
Bone Resorption ◽  
Animal Models ◽  
Middle Ear ◽  
Future Prospect ◽  
Pathological Condition ◽  
Current Status ◽  
Morphologic Characteristics ◽  
Middle Ear Cholesteatoma ◽  
Acquired Cholesteatoma

Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. Unfortunately, our understanding of the mechanism underlying its pathogenesis is limited. To investigate its pathogenesis, different animal models have been used. This paper provides a brief overview of the current status of research in the field of pathogenesis of middle ear acquired cholesteatoma, four types of animal models previously reported on, up-to-date cholesteatoma research using these animal models, our current studies of the local hybrid ear model, and the future prospect of new animal models of middle ear cholesteatoma.

Pediatric middle ear cholesteatoma: the comparative study of congenital cholesteatoma and acquired cholesteatoma

2015 ◽  
Vol 273 (5) ◽  
pp. 1155-1160 ◽  
Author(s):  
Yuka Morita ◽  
Yutaka Yamamoto ◽  
Shinsuke Oshima ◽  
Kuniyuki Takahashi ◽  
Sugata Takahashi
Keyword(s):  
Comparative Study ◽  
Middle Ear ◽  
Congenital Cholesteatoma ◽  
Middle Ear Cholesteatoma ◽  
Acquired Cholesteatoma ◽  
The Comparative Study

Effect of Certain Head and Neck Tumors and Their Treatment on the Ventilatory Function of the Eustachian Tube and Hearing Loss

1983 ◽  
Vol 92 (6_suppl) ◽  
pp. 24-25
Author(s):  
E. N. Myers ◽  
Q. C. Beery ◽  
C. D. Bluestone ◽  
M. B. Möller ◽  
B. A. Sigler ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Animal Models ◽  
Cleft Palate ◽  
Head And Neck ◽  
Middle Ear ◽  
Clinical Condition ◽  
Ventilatory Function ◽  
Neck Tumors ◽  
Pathological Conditions ◽  
Middle Ear Disease

The management of patients with middle ear disease should be based on an understanding of the pathogenesis of the disease and its course. In this group of investigations, patients with pathological conditions such as cleft palate, which affects ET function, are studied. Animal models are then developed to simulate the clinical condition, thus providing a method of isolating the variables.

Role of Langerhans cells, Ki-67 protein and apoptosis in acquired cholesteatoma: prospective clinical study

2013 ◽  
Vol 127 (3) ◽  
pp. 252-259 ◽  
Author(s):  
V Akdogan ◽  
I Yilmaz ◽  
T Canpolat ◽  
L N Ozluoglu
Keyword(s):  
Middle Ear ◽  
Langerhans Cells ◽  
Prospective Clinical Study ◽  
Ear Canal ◽  
Ki 67 ◽  
Middle Ear Cholesteatoma ◽  
Proliferation And Apoptosis ◽  
Acquired Cholesteatoma ◽  
Open Versus

AbstractObjective:To investigate the role of Langerhans cells in the pathogenesis and clinical picture of middle-ear cholesteatoma.Subjects and methods:The study included 40 patients operated upon for a diagnosis of chronic otitis due to acquired cholesteatoma.Results and analysis:A closed surgical technique was used in 20 per cent of patients and an open technique in 80 per cent. Langerhans cells were more densely accumulated in cholesteatoma epithelium, compared with external ear canal skin (p < 0.001). Staining for Ki-67 protein was greater in cholesteatoma epithelium (p < 0.001) and Apo2.7 protein staining (indicating apoptosis) was more prominent (p < 0.001), compared with ear canal skin. Regarding significant relationships between clinical and pathological findings, staining for Ki-67 (p = 0.046) and Apo2.7 (p = 0.037) was more prominent in patients undergoing open versus closed surgery.Conclusion:Using cell proliferation and apoptosis markers, a dense Langerhans cell infiltration was found to occur as a host response to middle-ear cholesteatoma.

scholarly journals Problems of middle ear and hearing in cleft children

2009 ◽  
Vol 42 (S 01) ◽  
pp. S144-S148
Author(s):  
Ramesh Kumar Sharma ◽  
Vipul Nanda
Keyword(s):  
Hearing Loss ◽  
Cleft Palate ◽  
Middle Ear ◽  
Otitis Media With Effusion ◽  
Review Article ◽  
Current Status ◽  
Palate Repair ◽  
Hearing Abilities ◽  
Recurrent Otitis Media

ABSTRACTThe hearing loss in a cleft patient is a well known complication, but generally gets ignored. These children continue to have recurrent otitis media with effusion that affects the hearing abilities. Unfortunatley the middle ear function may not improve with palatoplasty. Cleft palate teams need to follow up all such children beginning at birth and going into adulthood, decades after a ‘successful’ palate repair. These patients should have careful otological and audiological surveillance with appropriate interventions whenever required. The review article discusses the current status of hearing management in patients with cleft palate.

scholarly journals Expression of tumor necrosis factor Alpha, interleukin-1 and matrix metalloproteinase-9 and pathomorphological changes in acquired middle ear cholesteatoma

2021 ◽  
Vol 12 (1) ◽  
pp. 29-38
Author(s):  
Dalibor Vranješ ◽  
Predrag Špirić ◽  
Mirjana Gnjatić
Keyword(s):  
Middle Ear ◽  
Interleukin 1 ◽  
Tympanic Cavity ◽  
Middle Ear Mucosa ◽  
Necrosis Factor Alpha ◽  
Middle Ear Cholesteatoma ◽  
Acquired Cholesteatoma ◽  
Factor Alpha ◽  
Metalloproteinase 9 ◽  
Mucosal Hypertrophy

Introduction. The inflammatory mediators play a central role in the pathogenesis of the inflammatory process of the middle ear and cholesteatoma from the aspect of initiating and maintaining the inflammatory response to infection and lesion. The aim of the study was to examine if the presence of acquired cholesteatoma could predict pathomorphological changes of the tympanic cavity mucosa in relation to the control tissue of the inflamed middle ear mucosa and to examine and compare the expression levels of tumor necrosis factor-alpha (TNF-a), interleukin-1 (IL-1) and matrix metalloproteinase 9 (MMP-9) with pathomorphological changes in the middle ear mucosa in chronic otitis media (COM), with and without acquired cholesteatoma (AC). Methods. The immunohistochemical study included 178 patients of both sexes, aged 5 to 75, who underwent microsurgical treatment of COM from 2015 to 2018. Patients were divided into two groups based on the presence or absence of AC of the middle ear: 97 with cholesteatoma (CCOM) and 81 without cholesteatoma (COM). Samples of the perimatrix of AC and inflamed middle ear mucosa were taken intraoperatively. The condition of the tympanic cavity mucosa was examined by otomicroscopy exploration intraoperatively. The expression levels of TNF-a, IL-1 and MMP-9 were determined by immunohistochemical analysis. Results. The difference in the percentage distribution of patients according to the condition of the tympanic cavity mucosa between both groups was statistically significant (p <0.01) where in the COM group the highest frequency was 43.2% of patients with mucosal hypertrophy, and in the CCOM 56.7% with granulations. With highly positive expression of TNF-R2 and IL-1, a higher probability of the presence of mucosal hypertrophy and granulations can be expected, and with highly positive expression of MMP-9 the presence of granulations. Conclusion. Acquired middle ear cholesteatoma is a statistically significant predictor of the occurence of mucosal hypertrophy and granulations in the tympanic cavity in relation to the control tissue of the inflamed middle ear mucosa. The high expression of TNF-R2, IL-1 and MMP-9 shows a statistically significant association with the presence of granulations and mucosal hypertrophy in acquired middle ear cholesteatoma which may have clinical significance in the evaluation and prognosis of the disease.

Possible participation of acidic pH in bone resorption in middle ear cholesteatoma

2013 ◽  
Vol 124 (1) ◽  
pp. 245-250 ◽  
Author(s):  
Khac‐Hung Nguyen ◽  
Hideaki Suzuki ◽  
Toyoaki Ohbuchi ◽  
Tetsuro Wakasugi ◽  
Hiroki Koizumi ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Middle Ear ◽  
Acidic Ph ◽  
Middle Ear Cholesteatoma

Histology, Pathogenesis, and Treatment of Cholesteatoma

1984 ◽  
Vol 93 (4_suppl) ◽  
pp. 125-128 ◽  
Author(s):  
Maxwell Abramson ◽  
Hiroshi Moriyama ◽  
Cheng Chun Huang
Keyword(s):  
Animal Model ◽  
Bone Resorption ◽  
Connective Tissue ◽  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Increase Bone Resorption ◽  
Pathogenic Factors ◽  
Middle Ear Cholesteatoma

Factors present in cholesteatoma connective tissue induce bone resorption in chronic otitis media. The presence of skin and its products appears to exacerbate the destructive influence of connective tissue. One exacerbating factor is pressure, shown in an animal model to increase bone resorption by influencing the subepithelial connective tissue. Consideration of pathogenic factors provides a rationale for modifications in the treatment of middle ear cholesteatoma.

The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma

2016 ◽  
Vol 274 (5) ◽  
pp. 2071-2078 ◽  
Author(s):  
Shumin Xie ◽  
Xiaoli Wang ◽  
Jihao Ren ◽  
Wei Liu
Keyword(s):  
Bone Resorption ◽  
Middle Ear ◽  
Middle Ear Cholesteatoma
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