scholarly journals The role of a chemokine receptor, CCR2, in suppressing the development of arthritis in IL-1 receptor antagonist-deficient mice

2012 ◽  
Vol 32 (3) ◽  
pp. 124-131 ◽  
Author(s):  
Hiroshi Fujii ◽  
Tomohisa Baba ◽  
Masakazu Yamagishi ◽  
Mitsuhiro Kawano ◽  
Naofumi Mukaida
Keyword(s):  
Receptor Antagonist ◽  
Chemokine Receptor ◽  
Deficient Mice ◽  
Chemokine Receptor Ccr2

scholarly journals Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria

2003 ◽  
Vol 71 (6) ◽  
pp. 3648-3651 ◽  
Author(s):  
Elodie Belnoue ◽  
Fabio T. M. Costa ◽  
Ana M. Vigário ◽  
Tatiana Voza ◽  
Françoise Gonnet ◽  
...  
Keyword(s):  
T Cells ◽  
Cerebral Malaria ◽  
Chemokine Receptor ◽  
Experimental Cerebral Malaria ◽  
T Cell Migration ◽  
Mice Brain ◽  
The Brain ◽  
Deficient Mice ◽  
Chemokine Receptor Ccr2

ABSTRACT Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8+ T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+ T-cell migration to the brain was not abolished.

scholarly journals Role of interleukin-25 in development of spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice

2017 ◽  
Vol 12 ◽  
pp. 62-65
Author(s):  
Yasuharu Abe ◽  
Aya Nambu ◽  
Sachiko Yamaguchi ◽  
Ayako Takamori ◽  
Hajime Suto ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Interleukin 1 ◽  
Interleukin 1 Receptor Antagonist ◽  
Interleukin 25 ◽  
Deficient Mice

scholarly journals Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient mice

2006 ◽  
Vol 103 (10) ◽  
pp. 3781-3786 ◽  
Author(s):  
E. Trogan ◽  
J. E. Feig ◽  
S. Dogan ◽  
G. H. Rothblat ◽  
V. Angeli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chemokine Receptor ◽  
Foam Cells ◽  
Deficient Mice

scholarly journals Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived Dendritic Cells in Allergic Airway Inflammation

2013 ◽  
Vol 288 (23) ◽  
pp. 16262-16273 ◽  
Author(s):  
Keqiang Chen ◽  
Mingyong Liu ◽  
Ying Liu ◽  
Chunyan Wang ◽  
Teizo Yoshimura ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Chemokine Receptor ◽  
Allergic Airway Inflammation ◽  
Leukocyte Accumulation ◽  
Signal Relay ◽  
Cc Chemokine Receptor 2 ◽  
Chemokine Receptor Ccr2 ◽  
Formylpeptide Receptor

Chemoattractant receptors regulate leukocyte accumulation at sites of inflammation. In allergic airway inflammation, although a chemokine receptor CCR2 was implicated in mediating monocyte-derived dendritic cell (DC) recruitment into the lung, we previously also discovered reduced accumulation of DCs in the inflamed lung in mice deficient in formylpeptide receptor Fpr2 (Fpr2−/−). We therefore investigated the role of Fpr2 in the trafficking of monocyte-derived DCs in allergic airway inflammation in cooperation with CCR2. We report that in allergic airway inflammation, CCR2 mediated the recruitment of monocyte-derived DCs to the perivascular region, and Fpr2 was required for further migration of the cells into the bronchiolar area. We additionally found that the bronchoalveolar lavage liquid from mice with airway inflammation contained both the CCR2 ligand CCL2 and an Fpr2 agonist CRAMP. Furthermore, similar to Fpr2−/− mice, in the inflamed airway of CRAMP−/− mice, DC trafficking into the peribronchiolar areas was diminished. Our study demonstrates that the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially mediates the trafficking of DCs within the inflamed lung.

IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions

2007 ◽  
Vol 292 (1) ◽  
pp. G262-G267 ◽  
Author(s):  
Hitomi Seino ◽  
Haruyasu Ueda ◽  
Masahiro Kokai ◽  
Noriko M. Tsuji ◽  
Shinichiro Kashiwamura ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Restraint Stress ◽  
Histidine Decarboxylase ◽  
Water Immersion ◽  
Gastric Lesions ◽  
Wild Type ◽  
Stress Indicators ◽  
Prior Administration ◽  
Deficient Mice

A role of IL-18 in the induction of gastric lesions by water immersion and restraint stress (WRS) was investigated. When wild-type BALB/c mice were exposed to WRS, levels of IL-18 in the serum and stomach increased rapidly with the development of acute gastric lesions. In IL-18-deficient mice [IL-18 knockout (KO) mice] similarly exposed to WRS, no gastric lesions were observed, but the administration of IL-18 before exposure to WRS resulted in the induction of WRS-induced gastric lesions. WRS enhanced gastric histidine decarboxylase (HDC) activity with concomitant increases in gastric histamine content. In IL-18 KO mice, the WRS-induced elevation of gastric HDC activity and histamine levels was much less than that in wild-type mice, but it was augmented by prior administration of IL-18. Treatment of wild-type mice with cimetidine, a histamine H2 receptor antagonist, inhibited the formation of WRS-induced gastric lesions with no effect on the induction of gastric IL-18 by WRS. Levels of corticosterone, one of the stress indicators, were lower in IL-18 KO mice than in wild-type mice. The glucocorticoid receptor antagonist mifepristone had no effect on gastric IL-18 and histamine levels but aggravated the stress-induced gastric lesions, indicating that corticosterone was not involved in the IL-18-mediated formation of stress-induced gastric lesions. These results indicate that IL-18 is involved in the induction of gastric lesions by WRS through augmentation of HDC activity and production of histamine in the stomach.

The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis

2005 ◽  
Vol 83 (9) ◽  
pp. 672-681 ◽  
Author(s):  
Marlon P. Quinones ◽  
Carlos A. Estrada ◽  
Yogeshwar Kalkonde ◽  
Sunil K. Ahuja ◽  
William A. Kuziel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chemokine Receptor ◽  
Collagen Induced Arthritis ◽  
Therapeutic Targeting ◽  
Chemokine Receptor Ccr2
Sign in / Sign up

Export Citation Format

Share Document