The molecular structure and role of CCL2 (MCP‐1) and C‐C chemokine receptor CCR2 in skeletal biology and diseases

2021 ◽  
Author(s):  
Sipin Zhu ◽  
Mei Liu ◽  
Samuel Bennett ◽  
Ziyi Wang ◽  
Kevin D. G. Pfleger ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Chemokine Receptor ◽  
Skeletal Biology ◽  
Chemokine Receptor Ccr2

scholarly journals Signal Relay by CC Chemokine Receptor 2 (CCR2) and Formylpeptide Receptor 2 (Fpr2) in the Recruitment of Monocyte-derived Dendritic Cells in Allergic Airway Inflammation

2013 ◽  
Vol 288 (23) ◽  
pp. 16262-16273 ◽  
Author(s):  
Keqiang Chen ◽  
Mingyong Liu ◽  
Ying Liu ◽  
Chunyan Wang ◽  
Teizo Yoshimura ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Chemokine Receptor ◽  
Allergic Airway Inflammation ◽  
Leukocyte Accumulation ◽  
Signal Relay ◽  
Cc Chemokine Receptor 2 ◽  
Chemokine Receptor Ccr2 ◽  
Formylpeptide Receptor

Chemoattractant receptors regulate leukocyte accumulation at sites of inflammation. In allergic airway inflammation, although a chemokine receptor CCR2 was implicated in mediating monocyte-derived dendritic cell (DC) recruitment into the lung, we previously also discovered reduced accumulation of DCs in the inflamed lung in mice deficient in formylpeptide receptor Fpr2 (Fpr2−/−). We therefore investigated the role of Fpr2 in the trafficking of monocyte-derived DCs in allergic airway inflammation in cooperation with CCR2. We report that in allergic airway inflammation, CCR2 mediated the recruitment of monocyte-derived DCs to the perivascular region, and Fpr2 was required for further migration of the cells into the bronchiolar area. We additionally found that the bronchoalveolar lavage liquid from mice with airway inflammation contained both the CCR2 ligand CCL2 and an Fpr2 agonist CRAMP. Furthermore, similar to Fpr2−/− mice, in the inflamed airway of CRAMP−/− mice, DC trafficking into the peribronchiolar areas was diminished. Our study demonstrates that the interaction of CCR2 and Fpr2 with their endogenous ligands sequentially mediates the trafficking of DCs within the inflamed lung.

Molecular structure, expression, and the emerging role of Siglec‐15 in skeletal biology and cancer

2021 ◽  
Author(s):  
Sarah Rashid ◽  
Dezhi Song ◽  
Jinbo Yuan ◽  
Benjamin H. Mullin ◽  
Jiake Xu
Keyword(s):  
Molecular Structure ◽  
Skeletal Biology

Molecular structure, expression, and functional role of Clec11a in skeletal biology and cancers

2020 ◽  
Vol 235 (10) ◽  
pp. 6357-6365 ◽  
Author(s):  
Miao Wang ◽  
Jianmin Guo ◽  
Lingli Zhang ◽  
Vincent Kuek ◽  
Jiake Xu ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Functional Role ◽  
Skeletal Biology

scholarly journals Chemokine Receptor CCR2 Is Not Essential for the Development of Experimental Cerebral Malaria

2003 ◽  
Vol 71 (6) ◽  
pp. 3648-3651 ◽  
Author(s):  
Elodie Belnoue ◽  
Fabio T. M. Costa ◽  
Ana M. Vigário ◽  
Tatiana Voza ◽  
Françoise Gonnet ◽  
...  
Keyword(s):  
T Cells ◽  
Cerebral Malaria ◽  
Chemokine Receptor ◽  
Experimental Cerebral Malaria ◽  
T Cell Migration ◽  
Mice Brain ◽  
The Brain ◽  
Deficient Mice ◽  
Chemokine Receptor Ccr2

ABSTRACT Infection with Plasmodium berghei ANKA induces cerebral malaria in susceptible mice. Brain-sequestered CD8+ T cells are responsible for this pathology. We have evaluated the role of CCR2, a chemokine receptor expressed on CD8+ T cells. Infected CCR2-deficient mice were as susceptible to cerebral malaria as wild-type mice were, and CD8+ T-cell migration to the brain was not abolished.

The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis

2005 ◽  
Vol 83 (9) ◽  
pp. 672-681 ◽  
Author(s):  
Marlon P. Quinones ◽  
Carlos A. Estrada ◽  
Yogeshwar Kalkonde ◽  
Sunil K. Ahuja ◽  
William A. Kuziel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chemokine Receptor ◽  
Collagen Induced Arthritis ◽  
Therapeutic Targeting ◽  
Chemokine Receptor Ccr2

scholarly journals The role of a chemokine receptor, CCR2, in suppressing the development of arthritis in IL-1 receptor antagonist-deficient mice

2012 ◽  
Vol 32 (3) ◽  
pp. 124-131 ◽  
Author(s):  
Hiroshi Fujii ◽  
Tomohisa Baba ◽  
Masakazu Yamagishi ◽  
Mitsuhiro Kawano ◽  
Naofumi Mukaida
Keyword(s):  
Receptor Antagonist ◽  
Chemokine Receptor ◽  
Deficient Mice ◽  
Chemokine Receptor Ccr2
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