scholarly journals Evaluation of a Porous Hydroxyapatite Granule and Gelatin Hydrogel Microsphere Composite in Bone Regeneration

2017 ◽  
Vol 26 (2) ◽  
pp. 203-214 ◽  
Author(s):  
Kensho Yokota ◽  
Tomonori Matsuno ◽  
Yasuhiko Tabata ◽  
Izumi Mataga
Keyword(s):  
Bone Regeneration ◽  
Porous Hydroxyapatite ◽  
Gelatin Hydrogel ◽  
Hydrogel Microsphere ◽  
Hydroxyapatite Granule

scholarly journals Clinical application of injectable growth factor for bone regeneration: a systematic review

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Yutaka Kuroda ◽  
Toshiyuki Kawai ◽  
Koji Goto ◽  
Shuichi Matsuda
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Femoral Head ◽  
Bone Regeneration ◽  
Clinical Application ◽  
Present Report ◽  
Basic Research ◽  
Limb Ischemia ◽  
Efficacy And Safety ◽  
Gelatin Hydrogel

Abstract Bone regeneration has been the ultimate goal in the field of bone and joint medicine and has been evaluated through various basic research studies to date. Translational research of regenerative medicine has focused on three primary approaches, which are expected to increase in popularity: cell therapy, proteins, and artificial materials. Among these, the local injection of a gelatin hydrogel impregnated with the protein fibroblast growth factor (FGF)-2 is a biomaterial technique that has been developed in Japan. We have previously reported the efficacy of gelatin hydrogel containing injectable FGF-2 for the regenerative treatment of osteonecrosis of the femoral head. Injectable growth factors will probably be developed in the future and gain popularity as a medical approach in various fields as well as orthopedics. Several clinical trials have already been conducted and have focused on this technique, reporting its efficacy and safety. To date, reports of the clinical application of FGF-2 in revascularization for critical limb ischemia, treatment of periodontal disease, early bone union for lower limb fracture and knee osteotomy, and bone regeneration for osteonecrosis of the femoral head have been based on basic research conducted in Japan. In the present report, we present an extensive review of clinical applications using injectable growth factors and discuss the associated efficacy and safety of their administration.

scholarly journals Bone Regeneration by Lactoferrin Released from a Gelatin Hydrogel

2011 ◽  
Vol 22 (12) ◽  
pp. 1581-1589 ◽  
Author(s):  
Ryohei Takaoka ◽  
Yoshiaki Hikasa ◽  
Kentaro Hayashi ◽  
Yasuhiko Tabata
Keyword(s):  
Bone Regeneration ◽  
Gelatin Hydrogel

Porous Hydroxyapatite Bioceramic Scaffolds for Drug Delivery and Bone Regeneration

2011 ◽  
Vol 18 (19) ◽  
pp. 192019 ◽  
Author(s):  
Dagnija Loca ◽  
Janis Locs ◽  
Kristine Salma ◽  
Juris Gulbis ◽  
Ilze Salma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bone Regeneration ◽  
Porous Hydroxyapatite

Augmented Bone Regeneration Activity of Platelet-Rich Plasma by Biodegradable Gelatin Hydrogel

2005 ◽  
Vol 11 (7-8) ◽  
pp. 1224-1233 ◽  
Author(s):  
Akishige Hokugo ◽  
Makoto Ozeki ◽  
Osamu Kawakami ◽  
Keisuke Sugimoto ◽  
Kozo Mushimoto ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Platelet Rich Plasma ◽  
Gelatin Hydrogel

Porous hydroxyapatite scaffolds containing dual microspheres based on poly(lactide-co-glycolide) and chitosan for bone regeneration

2017 ◽  
Vol 188 ◽  
pp. 387-391 ◽  
Author(s):  
Qin Wang ◽  
Jinyu Li ◽  
Taotao Xu ◽  
Xiaoying Lu ◽  
Wei Zhi ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Porous Hydroxyapatite

Gelatin hydrogel carrier with the W9-peptide elicits synergistic effects on BMP-2-induced bone regeneration

2013 ◽  
Vol 55 (4) ◽  
pp. 217-223 ◽  
Author(s):  
Md. Abdullah Al Mamun ◽  
Md. Abdulla Al Masud Khan ◽  
Neil Alles ◽  
Makoto Matsui ◽  
Yasuhiko Tabata ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Synergistic Effects ◽  
Gelatin Hydrogel

scholarly journals Effects of Enhanced Hydrophilic Titanium Dioxide-Coated Hydroxyapatite on Bone Regeneration in Rabbit Calvarial Defects

2018 ◽  
Vol 19 (11) ◽  
pp. 3640 ◽  
Author(s):  
Ji-Eun Lee ◽  
Chung Bark ◽  
Hoang Quy ◽  
Seung-Jun Seo ◽  
Jae-Hong Lim ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Uv Irradiation ◽  
Early Stage ◽  
Healing Process ◽  
Negative Control ◽  
Control Group ◽  
Graft Material ◽  
Porous Hydroxyapatite ◽  
Significant Difference ◽  
Calvarial Defects

The regeneration of bone defects caused by periodontal disease or trauma is an important goal. Porous hydroxyapatite (HA) is an osteoconductive graft material. However, the hydrophobic properties of HA can be a disadvantage in the initial healing process. HA can be coated with TiO2 to improve its hydrophilicity, and ultraviolet irradiation (UV) can further increase the hydrophilicity by photofunctionalization. This study was designed to evaluate the effect of 5% TiO2-coated HA on rabbit calvarial defects and compare it with that of photofunctionalization on new bone in the early stage. The following four study groups were established, negative control, HA, TiO2-coated HA, and TiO2-coated HA with UV. The animals were sacrificed and the defects were assessed by radiography as well as histologic and histomorphometric analyses. At 2 and 8 weeks postoperatively, the TiO2-coated HA with UV group and TiO2-coated HA group showed significantly higher percentages of new bone than the control group (p < 0.05). UV irradiation increased the extent of new bone formation, and there was a significant difference between the TiO2-coated HA group and TiO2-coated HA with UV group. The combination of TiO2/HA and UV irradiation in bone regeneration appears to induce a favorable response.

scholarly journals Bone Regeneration and Remodeling within a Unidirectional Porous Hydroxyapatite Bone Substitute at a Cortical Bone Defect Site: Histological Analysis at One and Two Years after Implantation

Materials ◽  
2015 ◽  
Vol 8 (8) ◽  
pp. 4884-4894 ◽  
Author(s):  
Masashi Iwasashi ◽  
Toru Funayama ◽  
Arata Watanabe ◽  
Hiroshi Noguchi ◽  
Toshinori Tsukanishi ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Cortical Bone ◽  
Bone Defect ◽  
Bone Substitute ◽  
Histological Analysis ◽  
Porous Hydroxyapatite ◽  
Defect Site

Porous Hydroxyapatite Scaffolds by Polymer Sponge Method

2008 ◽  
Vol 396-398 ◽  
pp. 703-706 ◽  
Author(s):  
A.C.B.M. Fook ◽  
A.H. Aparecida ◽  
Thiago Bizerra Fideles ◽  
R.C. Costa ◽  
Marcus Vinícius Lia Fook
Keyword(s):  
Chemical Composition ◽  
Bone Regeneration ◽  
Bone Substitutes ◽  
High Porosity ◽  
Porous Hydroxyapatite ◽  
Pore Sizes ◽  
Hydroxyapatite Scaffold

This study aimed to develop porous hydroxyapatite scaffold for bone regeneration using the replica of the polymeric sponge technique. Polyurethane sponges were used with varying densities to obtain the scaffolds. The results indicate the porous HA scaffolds developed in this study as potential materials for application as bone substitutes to have high porosity (> 70%), chemical composition, interconnectivity and pore sizes appropriate to the bone regeneration.

scholarly journals Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment

Drug Delivery ◽  
2021 ◽  
Vol 28 (1) ◽  
pp. 319-324
Author(s):  
Xingwen Han ◽  
Jingjing He ◽  
Zhan Wang ◽  
Zhongtian Bai ◽  
Peng Qu ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Bone Regeneration ◽  
Fracture Treatment ◽  
Gelatin Hydrogel ◽  
Hydrogel System
Sign in / Sign up

Export Citation Format

Share Document