scholarly journals Analytical applications of electrode sensitive to labetalol in pharmaceuticals

2003 ◽  
Vol 1 (3) ◽  
pp. 242-259 ◽  
Author(s):  
Ewa Gorodkiewicz ◽  
Paweł Falkowski ◽  
Anna Sankiewicz ◽  
Zbigniew Figaszewski
Keyword(s):  
Liquid Membrane ◽  
Inorganic Ions ◽  
Structural Similarity ◽  
Protonated Form ◽  
Direct Potentiometry ◽  
Analytical Properties ◽  
Nernstian Slope ◽  
Ph Range ◽  
Influence Of Ph

AbstractThe analytical properties of an ion-selective electrode sensitive to labetalol with a liquid membrane, based on ion-pair complexes with sodium tetraphenylborate (TPB-Na+) are described. The studied electrode can be used for the determination of labetalol hydrochloride as a protonated form of labetalol in pharmaceuticals. The calibration curve, e.g. EMF=f(pCLabHCl) is linear in the range from 10−5 to 10−2 mol L−1 with a correlation coefficient of 0.9992 and slope of 61.13 mV/decade, which is close to the Nernstian slope. The detection limit of the examined electrode is 7.20×10−6 mol L−1. The influence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.0–8.0. The main attributes of the developed electrode are: stability, good reproducibility of EMF and short response time, close to 30 seconds depending on labetalol concentration in the solution. The electrode shows good selectivity for many inorganic ions. The selectivity for drug cations is weaker due to the structural similarity of the interfering cations to labetalol. The results of labetalol determination using direct potentiometry in drugs such as Pressocard (Polpharma) and Trandate (GlaxoWellcome) were compatible with the quantity of labetalol declared by the manufacturer, and with parallel UV spectrophotometric and HPLC determinations.

scholarly journals Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)

2020 ◽  
Vol 11 (1) ◽  
pp. 21-29 ◽  
Author(s):  
Iyad Darweesh Al-Kashef ◽  
Salman Mostafa Saadeh ◽  
Khalid Ibrahim Abed Almonem ◽  
Nasser Mohammed Abu Ghalwa ◽  
Hazem Mohammed Abu Shawish
Keyword(s):  
Anticancer Drug ◽  
Limit Of Detection ◽  
Inorganic Ions ◽  
Potentiometric Sensors ◽  
Pvc Membrane ◽  
Carbon Paste ◽  
Curve Method ◽  
Nernstian Slope ◽  
Ph Range

Accurate, rapid and inexpensive determination of gemcitabine, an anticancer drug, is of high interest. This manuscript describes the use of potentiometric sensors as a basis for this work given their known attractive characteristics that meet our needs. Potentiometric sensors were comprised of carbon paste S1, coated wire S2 and PVC membrane S3, of gemcitabine (an anticancer drug) were fabricated, studied and evaluated. The calibration plots for these electrodes showed a Nernstian slope of 58.4±0.3, 59.5±0.3 and 58.3±0.3 mV per decade with the limit of detection: 6.50×10-5, 7.20×10-5 and 4.60×10-5 for sensors S1, S2 and S3, respectively. The electrodes have a short and stable response time of ~5 seconds and good reproducibility in a pH range of 2.5-9.5. The present sensors show distinct selectivity toward the drug ion in comparison to several inorganic ions, sugars, amino acids and some common drug excipients. Gemcitabine was determined successfully in ampoules and urine using these sensors by the calibration curve method.

scholarly journals Determination of Nd3+Ions in Solution Samples by a Coated Wire Ion-Selective Sensor

2012 ◽  
Vol 9 (1) ◽  
pp. 83-88 ◽  
Author(s):  
Hassan Ali Zamani
Keyword(s):  
High Selectivity ◽  
Water Solution ◽  
Fast Response ◽  
Indicator Electrode ◽  
Coated Wire ◽  
Nernstian Slope ◽  
Ph Range ◽  
Coated Wire Electrode ◽  
Selective Sensor

A new coated wire electrode (CWE) using 5-(methylsulfanyl)-3-phenyl-1H-1,2,4-triazole (MPT) as an ionophore has been developed as a neodymium ion-selective sensor. The sensor exhibits Nernstian response for the Nd3+ions in the concentration range of 1.0×10−6-1.0×10−2M with detection limit of 3.7×10−7M. It displays a Nernstian slope of 20.2±0.2 mV/decade in the pH range of 2.7–8.1. The proposed sensor also exhibits a fast response time of ∼5 s. The sensor revealed high selectivity with respect to all common alkali, alkaline earth, transition and heavy metal ions, including members of the lanthanide family other than Nd3+. The electrode was used as an indicator electrode in the potentiometric titration of Nd(III) ions with EDTA. The electrode was also employed for the determination of the Nd3+ions concentration in water solution samples.

scholarly journals Potentiometric sensor for iron (III) quantitative determination: experimental and computational approaches

BMC Chemistry ◽  
2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Somayeh Badakhshan ◽  
Saeid Ahmadzadeh ◽  
Anoushiravan Mohseni-Bandpei ◽  
Majid Aghasi ◽  
Amir Basiri
Keyword(s):  
Tap Water ◽  
Basis Set ◽  
Stable Complex ◽  
Wastewater Sample ◽  
Adsorption Sites ◽  
Electrocoagulation Process ◽  
Nernstian Slope ◽  
Dynamic Concentration ◽  
Ph Range

AbstractThe current work deals with fabrication and validation of a new highly Fe3+ selective sensor based on benzo-18-crown-6 (b-18C6) using the potentiometric method. The proposed sensor revealed satisfactory performance for quantitative evaluation of Fe3+ trace amount in environmental samples. The ratio of membrane ingredients optimized and the membrane with the composition of 4:30:65.5:0.5 mg of b-18C6:PVC:o-NPOE:KTpClPB exhibited the desirable Nernstian slope of 19.51 ± 0.10 (mV per decade of activity) over the pH range from 2.5 to 5.7 with an acceptable dynamic concentration range of 1.0 × 10−6 M to 1.0 × 10−1 M and lower detection limit of 8.0 × 10−7 M. The proposed sensor demonstrated an appropriate reproducibility with a rapid response time of 12 s and the suitable lifetime of 10 weeks. To validate the accurate response of the proposed sensor, AAS technique applied for the determination of Fe3+ in real aqueous mediums such as drinking tap water and hospital wastewater sample after treatment by electrocoagulation process. Theoretical studies carried out using DFT/B3LYP computational level with 6-311G basis set to optimize the adsorption sites of Fe+3 cationic species by b-18C6. The obtained adsorption energy with large negative value confirmed the formation of a stable complex.

scholarly journals Construction of Eu3+Ion-Selective Electrode Based on 1,2-Diaminopropane-N,N,N',N'-tetraacetic acid

2011 ◽  
Vol 8 (s1) ◽  
pp. S467-S473 ◽  
Author(s):  
Mohammad Reza Abedi ◽  
Hassan Ali Zamani
Keyword(s):  
Alkaline Earth ◽  
Dynamic Range ◽  
Pvc Membrane ◽  
Membrane Electrode ◽  
Tetraacetic Acid ◽  
Pvc Membrane Electrode ◽  
Nernstian Slope ◽  
Wide Linear Dynamic Range ◽  
Ph Range

A new Eu3+PVC membrane electrode based on 1,2-diaminopropane-N, N,N',N'-tetraacetic acid (DAPTA) as a suitable ionophore has been prepared and studied. The electrode shows a good selectivity for Eu(III) ion with respect to most common cations including alkali, alkaline earth, transition and heavy metal ions. This electrode has a wide linear dynamic range from 1.0×10-6to 1.0×10-2M with a Nernstian slope of 19.7±0.5 mV per decade and a low detection limit of 7.2×10-7M in the pH range of 2.5–9.1, while the response time was rapid (<10 s). The practical utility of the electrodes has been demonstratedby their use as indicator electrodes in the potentiometric titration of Eu3+ions with EDTA and for the determination of Eu3+in some water sample solutions.

scholarly journals PVC-Membrane Potentiometric Electrochemical Sensor Based on 2-(4-Oxopentan-2-ylideneamino)isoindoline-1,3-dione for Selective Determination of Holmium(III)

2011 ◽  
Vol 8 (s1) ◽  
pp. S97-S104 ◽  
Author(s):  
Hassan Ali Zamani
Keyword(s):  
Heavy Metal Ions ◽  
Alkaline Earth ◽  
Fast Response ◽  
Pvc Membrane ◽  
Indicator Electrode ◽  
Selective Determination ◽  
Nernstian Slope ◽  
Neutral Ionophore ◽  
Ph Range

2-(4-Oxopentan-2-ylideneamino) isoindoline-1,3-dione (OID) was found to be a suitable neutral ionophore in the fabrication of a highly selective Ho3+membrane sensor. The electrode has a near-Nernstian slope of 19.6±0.5 mV per decade with a wide concentration range between 1.0×10-6and 1.0×10-2mol/L in the pH range of 3.5–8.8, having a fast response time (∼5 s) and a detection limit of 5.8×10-7mol/L. This electrode presented very good selectivity and sensitivity towards the Ho3+ions over a wide variety of cations, including alkali, alkaline earth, transition and heavy metal ions. The practical utility of the electrode has been demonstrated by its use as an indicator electrode for the potentiometric titration of a Ho3+solution with EDTA and for the determination of Ho3+ions concentration in mixtures of two and three different ions.

New Liquid Membrane Electrode for Determination of Lidocaine in Local Anesthetic Formulations

1986 ◽  
Vol 69 (4) ◽  
pp. 618-620
Author(s):  
Saad S M Hassan ◽  
Mona A Ahmed
Keyword(s):  
Local Anesthetic ◽  
Liquid Membrane ◽  
Pharmaceutical Preparations ◽  
Ion Pair ◽  
Membrane Electrode ◽  
Lidocaine Concentration ◽  
Ph Range ◽  
Liquid Membrane Electrode ◽  
The U.S

Abstract A new lidocaine-responsive liquid membrane electrode based on the use of the lidocaine reineckate ion pair complex in nitrobenzene solvent has been developed. The electrode displays a linear response for 10-2-10-5M lidocaine over the pH range of 3-6.5. The response time varies from 35 s to 1 min depending on the lidocaine concentration. The life span of the electrode is at least 1 month. Excipients and diluents commonly used in local anesthetic formulations do not interfere. Determination of lidocaine in some pharmaceutical preparations gives results with an average recovery of 99% of the nominal values and a mean standard deviation of 1.7% which compare favorably with those obtained by the U.S. Pharmacopeia method.

scholarly journals Novel Potentiometric 2,6-Dichlorophenolindo-phenolate (DCPIP) Membrane-Based Sensors: Assessment of Their Input in the Determination of Total Phenolics and Ascorbic Acid in Beverages

Sensors ◽  
2019 ◽  
Vol 19 (9) ◽  
pp. 2058 ◽  
Author(s):  
Nada H. A. Elbehery ◽  
Abd El-Galil E. Amr ◽  
Ayman H. Kamel ◽  
Elsayed A. Elsayed ◽  
Saad S. M. Hassan
Keyword(s):  
Direct Determination ◽  
Inorganic Ions ◽  
Ion Association ◽  
Fast Response ◽  
Plasticized Pvc ◽  
Promising Tool ◽  
Total Antioxidant ◽  
Nernstian Slope ◽  
High Potential Stability

In this work, we demonstrated proof-of-concept for the use of ion-selective electrodes (ISEs) as a promising tool for the assessment of total antioxidant capacity (TAC). Novel membrane sensors for 2,6-dichlorophenolindophenolate (DCPIP) ions were prepared and characterized. The sensors membranes were based on the use of either CuII-neocuproin/2,6-dichlorophenolindo-phenolate ([Cu(Neocup)2][DCPIP]2) (sensor I), or methylene blue/2,6-dichlorophenolindophenolate (MB/DCPIP) (sensor II) ion association complexes in a plasticized PVC matrix. The sensors revealed significantly enhanced response towards DCPIP ions over the concentration range 5.13 × 10−5–1.0 × 10−2 and 5.15 × 10−5–1.0 × 10−2 M at pH 7 with detection limits of 6.3 and 9.2 µg/mL with near-Nernstian slope of −56.2 ± 1.7 and −51.6 ± 2 mV/decade for sensors I and II, respectively. The effects of plasticizers and various foreign common ions were also tested. The sensors showed enhanced selectivity towards DCPIP over many other phenolic and inorganic ions. Long life span, high potential stability, high reproducibility, and fast response were also observed. Method validation was also verified by measuring the detection limit, linearity range, accuracy, precision, repeatability and between-day-variability. The sensors were introduced for direct determination of TAC in fresh and canned juice samples collected from local markets. The obtained results agreed fairly well with the data obtained by the standard method.

scholarly journals Construction and Evaluation of Scopolamine Ion- Selective Electrode

2000 ◽  
Vol 68 (3) ◽  
pp. 247-261
Author(s):  
A. Shalaby ◽  
M. El-Maamly ◽  
H. Abdellatef
Keyword(s):  
Pharmaceutical Preparations ◽  
Electrode System ◽  
Potentiometric Determination ◽  
Membrane Electrode ◽  
Selective Membrane ◽  
Nernstian Slope ◽  
Ion Associate ◽  
Ph Range ◽  
Associate Species

The construction of plasticised PVC matrix-type scopolamine ion- selective membrane electrode and its use in the potentiometric determination of scopolamine in pharmaceutical preparations are described. It is based on the use of tlie ion-associate species, fonned by scopolainine cation and 5-nitrobarbitoric counter ion. The basic electrode peifonnance characteristics are evaluated according to IUPAC I-ecoininendatioiis. It exhibited a linear response for 1x10-2–1x10-5 M of scopolamine solutions with a cationic Nernstian slope over the pH range of 4-7. Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 1x10-2–1x10-5 M aqueous tubocurarine chloride using this membrane electrode system showed an average recovery of 99.05 with a mean standard deviation of 0.12. This electrode system was successfully applied to the potentiometric determination of scopolamine in some pharmaceutical preparations.

scholarly journals Liquid membrane ion-selective electrodes for potentiometric dosage of coper and nickel

2005 ◽  
Vol 70 (2) ◽  
pp. 269-276 ◽  
Author(s):  
Maria Pleniceany ◽  
Marian Isvoranu ◽  
Cezar Spinu
Keyword(s):  
Liquid Membrane ◽  
Organic Ligand ◽  
Theoretical Data ◽  
Membrane Electrodes ◽  
Nickel Ions ◽  
Direct Potentiometry ◽  
Graphite Rod ◽  
Active Substances

This paper presents experimental and theoretical data regarding the preparation and characterization of three liquid-membrane electrodes, which have not been mentioned in the specialized literature so far. The active substances, the solutions of which in nitrobenzene formed the membranes on a graphite rod, are simple complex combinations of Cu(II) and Ni(II) ions with an organic ligand belonging to the Schiff base class: N-[2-thienylmethilidene]-2-aminoethanol (TNAHE). The Cu2+ -selective and Ni2+ -selective electrodes were used to determine the copper and nickel ions in aqueous solutions, both by direct potentiometry and by potentiometric titration with EDTA. They were also used for the determination of Cu2+ and Ni2+ ions in industrial waters by direct potentiometry.

scholarly journals Studies on a Pb2+ - selective electrode with a macrocyclic liquid membrane: Potentiometric determination of pb2+ ions

2006 ◽  
Vol 71 (12) ◽  
pp. 1345-1352 ◽  
Author(s):  
Marian Isvoranu ◽  
Constantin Luca ◽  
Maria Pleniceanu ◽  
Cezar Spinu
Keyword(s):  
Atomic Absorption Spectrometry ◽  
Liquid Membrane ◽  
Theoretical Data ◽  
Absorption Spectrometry ◽  
Systematic Errors ◽  
Ion Selective Electrode ◽  
Selective Electrode ◽  
Active Complex ◽  
Direct Potentiometry

This paper presents experimental and theoretical data regarding the design, characterization and analytical applications of a non-expensive, liquid-membrane ion-selective electrode for Pb2+ ions. The membrane is a solution of the active complex formed by Pb2+ ions with dibenzo-18-crown-6-ionophore (DB-[18]-C-6) extracted in propylene carbonate (PC). The successful application of the developed electrode for the determination of Pb2+ ions in aqueos solution samples by direct potentiometry and potentiometric titration is presented. For the presented analytical results, there are insignificant systematic errors between the direct potentiometric method with the developed ion-selective electrode and atomic absorption spectrometry. .

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