DEXEDRINE (D-AMPHETAMINE SULFATE) AND LABORATORY-INDUCED ANXIETY

1960 ◽  
Vol 7 (7) ◽  
pp. 415
Author(s):  
G. Y. KENYON
Keyword(s):  
Amphetamine Sulfate

HYPERKALEMIC FAMILIAL PERIODIC PARALYSIS

PEDIATRICS ◽  
1959 ◽  
Vol 24 (5) ◽  
pp. 761-773
Author(s):  
T. J. Egan ◽  
R. Klein
Keyword(s):  
Urinary Excretion ◽  
Opposite Direction ◽  
Recovery Period ◽  
Acute Attack ◽  
Periodic Paralysis ◽  
Hospitalized Patients ◽  
High Concentration ◽  
Definite Improvement ◽  
Dextro Amphetamine ◽  
Amphetamine Sulfate

The clinical histories of three families are described, who have a variant of familial periodic paralysis characterized by high concentration of potassium during paralytic episodes unassociated with diminished urinary excretion of potassium. Data are presented concerning five hospitalized patients from the three families. The data indicate that the rise in concentration of potassium in serum results from a shift of potassium into the extracellular phase. During the recovery period potassium travels in the opposite direction. The administration of glucagon or epinephrine during an acute attack terminated the attack promptly. The administration of 10 to 15 mg of dextro-amphetamine sulfate daily in Spansule® form effectively controlled symptoms in two patients, and resulted in definite improvement in a third patient, treated for periods varying from 3 to 7 months.

Dexedrine (D-Amphetamine Sulfate) and Laboratory-Induced Anxiety

1960 ◽  
Vol 7 (3) ◽  
pp. 415-433
Author(s):  
G. Y. Kenyon ◽  
N. H. Pronko
Keyword(s):  
Amphetamine Sulfate

Collaborative Study of the Gas-Liquid Chromatographic Method for Determination of Stereochemical Composition of Amphetamine

1972 ◽  
Vol 55 (1) ◽  
pp. 146-148
Author(s):  
Clyde E Wells
Keyword(s):  
Column Chromatography ◽  
Chromatographic Method ◽  
Collaborative Study ◽  
Good Precision ◽  
Liquid Chromatographic Method ◽  
Precision And Accuracy ◽  
Standard Deviations ◽  
Liquid Chromatographic ◽  
Amphetamine Sulfate

Abstract Eight laboratories collaboratively studied a method for the quantitative GLC determination of d- and l-amphetamine in tablets. The drugs are separated from tablet excipients by column chromatography and reacted with Ntrifluoroacetyl-( 0-prolyl chloride, and the resulting derivatives are analyzed by GLC. The samples consisted of commercial d-amphetamine sulfate tablets (with and without butabarbital), dl-amphetamine sulfate tablets, and a mixed d- and l-amphetamine sulfate standard. Recoveries were acceptable, and the standard deviations never exceeded 0.64%. The results demonstrate that the method gives good precision and accuracy, and the method is recommended for adoption as official first action.

A method for chronic intravenous drug administration in squirrel monkeys

1970 ◽  
Vol 48 (8) ◽  
pp. 575-581 ◽  
Author(s):  
Roger Stretch ◽  
Gary J. Gerber
Keyword(s):  
Drug Administration ◽  
Blood Stream ◽  
Squirrel Monkeys ◽  
Intravenous Drug ◽  
Intravenous Catheter ◽  
Response Contingent ◽  
Amphetamine Sulfate

A system for the infusion of drug solutions into the blood stream of relatively unrestrained and unanesthetized squirrel monkeys, via a chronic intravenous catheter, is described. Results pertaining to the maintenance of schedule-controlled behavior by response-contingent infusions of d-amphetamine sulfate are included to illustrate a specific application of the technique.

scholarly journals 81 Bioequivalence of a Manipulation-Resistant Immediate-Release Amphetamine Sulfate Formulation Compared with Reference Standard

CNS Spectrums ◽  
2019 ◽  
Vol 24 (1) ◽  
pp. 216-216
Author(s):  
Steve Caras ◽  
Terrilyn Sharpe
Keyword(s):  
Single Dose ◽  
Healthy Volunteers ◽  
Peak Concentration ◽  
Immediate Release ◽  
Open Label ◽  
Time Curve ◽  
Time To Peak ◽  
Amphetamine Sulfate ◽  
Quantifiable Concentration ◽  
Funding Acknowledgements

AbstractStudy ObjectivesWe compared the bioavailability of racemic amphetamine (d-amphetamine and l-amphetamine) from a manipulation-resistant immediate-release (IR) amphetamine sulfate capsule (AR19) versus amphetamine sulfate IR tablets (reference).MethodIn this open-label, randomized, two-period, two-treatment, two-sequence, crossover study, 36 healthy volunteers aged 18–45 received a single dose (20-mg capsule) of AR19 in one period and a single dose (2 x 10-mg tablets) of reference in another period, after a 10-hour overnight fast. Each drug administration was separated by a washout period of at least 6days. Bioequivalence for d- and l-amphetamine was assessed using time to peak concentration (Tmax), peak concentration in plasma (Cmax), and area under the plasma concentration–time curve from time-zero to the time of the last quantifiable concentration (AUClast) and extrapolated to infinity (AUCinf).ResultsAll 36 volunteers completed both treatment sequences. Mean (standard deviation; SD) Tmax for d- and l-amphetamine was similar for AR19 (2.84[1.05]; 3.05[1.22], respectively) and reference (2.52[0.75]; 2.75[1.00], respectively). The geometric least-squares mean ratios and 90% confidence intervals were within the boundary of 80%–125% for bioequivalence for Cmax (d-amphetamine, 98.35% [96.12–100.64]; l-amphetamine, 98.82% [96.42–101.28]), AUClast (d-amphetamine, 99.45% [96.92–102.05]; l-amphetamine, 99.29% [96.55–102.10]), and AUCinf (d-amphetamine, 99.50%[96.77–102.30]; l-amphetamine, 99.23% [96.06–102.50]). A total of 13 mild adverse events were reported by 7 volunteers (AEs; AR19, n=5; reference, n=8). No serious AEs were reported.ConclusionAR19 was well tolerated and was bioequivalent to reference when administered as a 20-mg dose in healthy volunteers.Funding Acknowledgements: This study was funded by Arbor Pharmaceuticals, LLC.

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