Comparison of two tourniquets and determination of amikacin sulfate concentrations after metacarpophalangeal joint lavage performed simultaneously with intravenous regional limb perfusion in horses

2011 ◽  
Vol 72 (5) ◽  
pp. 613-619 ◽  
Author(s):  
Stephane B. Alkabes ◽  
Stephen B. Adams ◽  
George E. Moore ◽  
Kira C. Alkabes
Keyword(s):  
Metacarpophalangeal Joint ◽  
Limb Perfusion ◽  
Amikacin Sulfate ◽  
Joint Lavage

Determination of the prevalence and severity of metacarpophalangeal joint osteoarthritis in Thoroughbred racehorses via quantitative macroscopic evaluation

2010 ◽  
Vol 71 (11) ◽  
pp. 1284-1293 ◽  
Author(s):  
Richelle H. Neundorf ◽  
Mark B. Lowerison ◽  
Antonio M. Cruz ◽  
Jeff J. Thomason ◽  
Beverley J. McEwen ◽  
...  
Keyword(s):  
Metacarpophalangeal Joint ◽  
Thoroughbred Racehorses

Use of vitamin B12 in joint lavage for determination of dilution factors of canine synovial fluid

2005 ◽  
Vol 66 (11) ◽  
pp. 1903-1906 ◽  
Author(s):  
Tanya de Bruin ◽  
Hilde de Rooster ◽  
Henri van Bree ◽  
Eric Cox
Keyword(s):  
Synovial Fluid ◽  
Vitamin B12 ◽  
Joint Lavage

scholarly journals Quantitative determination of amikacin Sulfate using vanillin from pure and commercial brands available in Pakistan

2015 ◽  
Vol 8 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Ubed-Ur Rehman Mughal ◽  
Abdullah Dayo ◽  
Muhammad Ali Ghoto ◽  
Madan Lal ◽  
Mudassar Iqbal Arain ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Amikacin Sulfate

Effect of Dose on Intra-Articular Amikacin Sulfate Concentrations Following Intravenous Regional Limb Perfusion in Horses

2016 ◽  
Vol 45 (8) ◽  
pp. 1077-1082 ◽  
Author(s):  
Alison Harvey ◽  
Isabelle Kilcoyne ◽  
Barbara A. Byrne ◽  
Jorge Nieto
Keyword(s):  
Limb Perfusion ◽  
Amikacin Sulfate

scholarly journals Reagent-free determination of amikacin content in amikacin sulfate injections by FTIR derivative spectroscopy in a continuous flow system

2014 ◽  
Vol 4 (2) ◽  
pp. 125-131 ◽  
Author(s):  
José F. Ovalles ◽  
Máximo Gallignani ◽  
María R. Brunetto ◽  
Rebeca A. Rondón ◽  
Carlos Ayala
Keyword(s):  
Continuous Flow ◽  
Flow System ◽  
Continuous Flow System ◽  
Derivative Spectroscopy ◽  
Amikacin Sulfate

scholarly journals Intra-articular concentration of gentamicin administered by intravenous regional limb perfusion in healthy horses

2020 ◽  
Vol 50 (11) ◽  
Author(s):  
Renan Grigoletto ◽  
Renata Gebara Sampaio Dória ◽  
Gustavo Morandini Reginato ◽  
Pedro Henrique Salles Brito ◽  
Marília Alves Ferreira ◽  
...  
Keyword(s):  
Minimum Inhibitory Concentration ◽  
Synovial Fluid ◽  
Efficient Method ◽  
Inhibitory Concentration ◽  
Metacarpophalangeal Joint ◽  
Maximal Concentration ◽  
Treatment Groups ◽  
Limb Perfusion ◽  
Dose Volume ◽  
Ringer’S Lactate

ABSTRACT: Intravenous regional limb perfusion (IRLP) is an efficient method to treat horses with synovial infections. However, information on the dose, volume, and intervals of administration is lacking. The aim of this study was to evaluate the intra-articular concentration of gentamicin administered by IRLP in horses over 24 h post-administration and evaluate the influence of the total perfused volume. Twenty horses were assigned to two treatment groups. Gentamicin 60 group (G60, n=10) and Gentamicin 250 group (G250, n=10) received IRLP of 6.6 mg/kg of gentamicin diluted in Ringer’s lactate for a total volume of 60 ml (G60) and 250 ml (G250), respectively. Synovial fluid harvests were performed in the metacarpophalangeal joint before (0) and 4, 8, 12, 16, 20, and 24 hours after IRLP. Agar diffusion was the assay for measuring gentamicin concentrations. Four hours after IRLP, the intra-articular concentration of gentamicin was 47.58±49.21 μg/ml in G60 and 10.92±6.11 μg/ml in G250. During the 24 h of harvest, the intra-articular concentration of gentamicin remained above the minimum inhibitory concentration for horses (MIC; 2 μg/ml) in both experimental groups. In G60, the concentration of gentamicin in synovial fluid reached the maximal concentration and remained 8 to 10-fold higher than the MIC (Cmax: 16 to 20 μg/ml) during 12 h after IRLP. These findings support that IRLP with 6.6 mg/kg of gentamicin diluted to a volume of 60 ml promotes intra-articular concentrations higher than 250 ml, remaining above the MIC for 24 h and at the maximum concentration for 12 h.

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