Effect of passive immunity on the development of a protective immune response against bovine viral diarrhea virus in calves

2003 ◽  
Vol 64 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Julia F. Ridpath ◽  
John D. Neill ◽  
Janet Endsley ◽  
James A. Roth
Keyword(s):  
Immune Response ◽  
Bovine Viral Diarrhea Virus ◽  
Protective Immune Response ◽  
Passive Immunity ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus

scholarly journals Recombinant Bovine Adenovirus Type 3 Expressing Bovine Viral Diarrhea Virus Glycoprotein E2 Induces an Immune Response in Cotton Rats

Virology ◽  
2000 ◽  
Vol 278 (1) ◽  
pp. 234-243 ◽  
Author(s):  
Mohit K. Baxi ◽  
Dirk Deregt ◽  
Jill Robertson ◽  
Lorne A. Babiuk ◽  
Tobias Schlapp ◽  
...  
Keyword(s):  
Immune Response ◽  
Bovine Viral Diarrhea Virus ◽  
Adenovirus Type ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Cotton Rats ◽  
Bovine Adenovirus Type 3 ◽  
Type 3 ◽  
Viral Diarrhea Virus

scholarly journals Recent Advances on the Bovine Viral Diarrhea Virus Molecular Pathogenesis, Immune Response, and Vaccines Development

2021 ◽  
Vol 8 ◽  
Author(s):  
Anwar A. G. Al-Kubati ◽  
Jamal Hussen ◽  
Mahmoud Kandeel ◽  
Abdullah I. A. Al-Mubarak ◽  
Maged Gomaa Hemida
Keyword(s):  
Immune Response ◽  
Viral Infection ◽  
Bovine Viral Diarrhea Virus ◽  
Molecular Pathogenesis ◽  
Bovine Viral Diarrhea ◽  
E2 Protein ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Novel Targets ◽  
Viral Diarrhea Virus

The bovine viral diarrhea virus (BVDV) consists of two species and various subspecies of closely related viruses of varying antigenicity, cytopathology, and virulence-induced pathogenesis. Despite the great ongoing efforts to control and prevent BVDV outbreaks and the emergence of new variants, outbreaks still reported throughout the world. In this review, we are focusing on the molecular biology of BVDV, its molecular pathogenesis, and the immune response of the host against the viral infection. Special attention was paid to discuss some immune evasion strategies adopted by the BVDV to hijack the host immune system to ensure the success of virus replication. Vaccination is one of the main strategies for prophylaxis and contributes to the control and eradication of many viral diseases including BVDV. We discussed the recent advances of various types of currently available classical and modern BVDV vaccines. However, with the emergence of new strains and variants of the virus, it is urgent to find some other novel targets for BVDV vaccines that may overcome the drawbacks of some of the currently used vaccines. Effective vaccination strategy mainly based on the preparation of vaccines from the homologous circulating strains. The BVDV-E2 protein plays important role in viral infection and pathogenesis. We mapped some important potential neutralizing epitopes among some BVDV genomes especially the E2 protein. These novel epitopes could be promising targets against the currently circulating strains of BVDV. More research is needed to further explore the actual roles of these epitopes as novel targets for the development of novel vaccines against BVDV. These potential vaccines may contribute to the global eradication campaign of the BVDV.

scholarly journals Protection of Piglets with Maternally Derived Antibodies from Sows Inoculated with an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns)

Pathogens ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 608
Author(s):  
SeEun Choe ◽  
Jihye Shin ◽  
Ki-Sun Kim ◽  
Sok Song ◽  
Ra Mi Cha ◽  
...  
Keyword(s):  
Bovine Viral Diarrhea Virus ◽  
Classical Swine Fever Virus ◽  
Protective Efficacy ◽  
Classical Swine Fever ◽  
Antibody Detection ◽  
Passive Immunity ◽  
Bovine Viral Diarrhea ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus

Here, we investigated the protective efficacy provided by passive immunity induced by a classical swine fever (Flc-LOM-BErns) vaccine with the newly developed DIVA (Differentiating Infected from Vaccinated Animals) function. Ten pigs (aged 40–60 days) with maternally derived antibodies (MDAs) obtained from sows inoculated with the Flc-LOM-BErns vaccine were challenged with virulent classical swine fever virus (CSFV). Pigs with an MDA titer of 6 log2 induced by the Flc-LOM-BErns vaccine were fully protected against virulent CSFV challenge but not the pigs with an MDA titer under 5 log2. In addition, Flc-LOM-BErns vaccine-derived MDAs successfully differentiated vaccinated pigs by bovine viral diarrhea virus (BVDV) Erns/CSFV Erns antibody detection, functioning as a DIVA.

scholarly journals Fusion to C3d Enhances the Immunogenicity of the E2 Glycoprotein of Type 2 Bovine Viral Diarrhea Virus

2004 ◽  
Vol 78 (4) ◽  
pp. 1616-1622 ◽  
Author(s):  
Lingshu Wang ◽  
J. Oriol Sunyer ◽  
Leonard J. Bello
Keyword(s):  
Immune Response ◽  
Bovine Viral Diarrhea Virus ◽  
Neutralizing Antibodies ◽  
Primary Immune Response ◽  
Enzyme Linked Immunosorbent Assay ◽  
Bovine Viral Diarrhea ◽  
Protein Subunit ◽  
Diarrhea Virus ◽  
Viral Diarrhea ◽  
Viral Diarrhea Virus

ABSTRACT The use of DNA and protein subunit vaccines in animals provides an opportunity to introduce vaccines that are arguably the safest that can be developed. For that reason, considerable effort is under way to devise methods of enhancing the immunogenicity of such vaccines. Seven years ago it was shown that fusing complement fragment C3d to hen egg lysozyme (HEL) enhanced the immunogenicity of HEL 10,000-fold. Based on this observation, we decided to evaluate the effect of C3d on the immunogenicity of the E2 protein of bovine viral diarrhea virus (BVDV). E2 is the major target of neutralizing antibody during BVDV infection. To test the effect of C3d on E2 immunogenicity, expression cassettes encoding a secreted form of E2 alone (E2s) or E2 fused to three copies of murine C3d (E2s-C3d) were constructed. The proteins were purified from the supernatants of transfected cells and used to immunize mice. The immune response was monitored by an enzyme-linked immunosorbent assay (ELISA) for E2s-specific antibody and by a virus neutralization test. The ELISA results indicated that the E2s-C3d protein is 10,000-fold more immunogenic than the E2s protein alone. The maximum primary immune response was elicited with <0.1 μg of E2s-C3d protein without an adjuvant. In addition, we have shown for the first time that high levels of anti-E2s and neutralizing antibodies can be elicited when this same low concentration of E2s-C3d is used to both prime and boost the immune response. We conclude that the E2s-C3d fusion protein has significant potential as a subunit vaccine against BVDV infection.

Sign in / Sign up

Export Citation Format

Share Document