Evaluation of the safety of an abbreviated course of injections of allergen extracts (rush immunotherapy) for the treatment of dogs with atopic dermatitis

2001 ◽  
Vol 62 (3) ◽  
pp. 307-310 ◽  
Author(s):  
Ralf S. Mueller ◽  
Sonya V. Bettenay
Keyword(s):  
Atopic Dermatitis ◽  
Rush Immunotherapy ◽  
Allergen Extracts

Efficacy and safety of rush immunotherapy with alumprecipitated allergens in canine atopic dermatitis

2014 ◽  
Vol 42 (03) ◽  
pp. 162-173
Author(s):  
Ralf Mueller ◽  
S. Hobi
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Allergen Immunotherapy ◽  
Specific Treatment ◽  
Small Animal ◽  
Common Disease ◽  
Efficacy And Safety ◽  
Canine Atopic Dermatitis ◽  
Rush Immunotherapy ◽  
Clinical Problems

Summary Objectives: Canine atopic dermatitis is a very common disease in small animal practice. Its only specific treatment is allergen immunotherapy. In rush-immunotherapy (RIT) increasing doses of allergen extract are injected subcutaneously in short intervals. Maintenance doses are achieved within one day compared to weeks or months with conventional immunotherapy. The aim of this study was to evaluate the safety and efficacy of RIT with alum-precipitated allergens. Materials and methods: A series of 20 dogs with atopic dermatitis underwent RIT with alum-precipitated allergens. Pruritus and medications at the start of the immunotherapy and 12 months afterwards were compared and adverse effects were recorded. Results: Significant improvement in pruritus (p = 0.0001) and medication scores (p = 0.0004) was noted after approximately 12 months of treatment. The observed clinical response was good to excellent in 70% of the dogs, consistent with other published reports. One dog vomited once during the induction day, with no other clinical problems and completion of the normal protocol. The other 19 dogs showed no adverse effects at all during or after RIT. Conclusion and clinical relevance: RIT with alum-precipitated allergens seems to be a safe and efficacious method to treat dogs with atopic dermatitis.

scholarly journals Conventional and rush immunotherapy in canine atopic dermatitis

2004 ◽  
Vol 15 (s1) ◽  
pp. 4-4 ◽  
Author(s):  
R. S. Mueller ◽  
K. V. Fieseler ◽  
S. Zabel ◽  
R. A. W. Rosychuk
Keyword(s):  
Atopic Dermatitis ◽  
Canine Atopic Dermatitis ◽  
Rush Immunotherapy

Efficacy of 10-Injection Induced Modified Rush Immunotherapy in Dogs with Atopic Dermatitis

2020 ◽  
Vol 37 (3) ◽  
pp. 141-144
Author(s):  
Hyun-Tae Kim ◽  
Wang-Hui Lee ◽  
Seong-Jun Park
Keyword(s):  
Atopic Dermatitis ◽  
Rush Immunotherapy

Safety of an Ultra-Rush Immunotherapy Build-Up Schedule with Therapeutic Vaccines Containing Depigmented and Polymerized Allergen Extracts

2006 ◽  
Vol 139 (2) ◽  
pp. 153-158 ◽  
Author(s):  
M. Casanovas ◽  
R. Martín ◽  
C. Jiménez ◽  
R. Caballero ◽  
E. Fernández-Caldas
Keyword(s):  
Therapeutic Vaccines ◽  
Rush Immunotherapy ◽  
Allergen Extracts

scholarly journals Do Human Mite Allergen Extracts Contain the Relevant Allergens for Treating Canine Atopic Dermatitis?

2017 ◽  
Vol 139 (2) ◽  
pp. AB259
Author(s):  
Raquel Moya ◽  
Jerónimo Carnés ◽  
Nuria Sinovas ◽  
Laura Ramio ◽  
Pilar Brazis ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mite Allergen ◽  
Canine Atopic Dermatitis ◽  
Allergen Extracts

scholarly journals Rush sublingual immunotherapy in canine atopic dermatitis: a prospective pilot study

2016 ◽  
Vol 19 (1) ◽  
pp. 3-6 ◽  
Author(s):  
M. Fujimura ◽  
H. Ishimaru
Keyword(s):  
Atopic Dermatitis ◽  
Adverse Effects ◽  
Sublingual Immunotherapy ◽  
Pilot Trial ◽  
Maintenance Phase ◽  
Severity Index ◽  
Canine Atopic Dermatitis ◽  
Prospective Pilot Study ◽  
Environmental Allergen ◽  
Allergen Extracts

Abstract Twenty dogs with canine atopic dermatitis (CAD) were treated with rush sublingual immunotherapy (SLIT), with a 48 hour build-up phase and 6 months maintenance phase (treated by antigen once every 3-4 weeks). The canine atopic dermatitis extent and severity index (CADESI)-4 was evaluated before treatment (baseline) and after 6 months. An open, non-controlled, non-randomized pilot trial was conducted to assess the effectiveness and safety of rush SLIT for environmental allergen extracts (Dematophagoides pteronyssinus and D.farinae mix and other). Three dogs dropped out and 17 dogs finished the trial. CADESI-4 at baseline was 60.6±27.1 (range 17-107, n=17). After 6 months of SLIT treatment, CADESI-4 was 37.4±36.0 (range 5-152, n=17) (p <0.01), which was a 38.3% reduction. A significant improvement, defined as a CADESI-4 reduction of > 30%, was observed in 13 out of 17 dogs (76%). A moderate improvement, defined as a CADESI-4 reduction of ≦30%, was observed in 2 dogs (12%). In the other 2 dogs (12%), CADESI-4 worsened or showed no change. However, no severe adverse effects were observed during the trial. Therefore, rush SLIT against environmental allergen extract for CAD showed effectiveness and safety as evidenced by the reduction of CADESI-4 after 6 months SLIT without severe adverse effects.

scholarly journals Safety and Utility of Rush Immunotherapy with Aqueous Allergen Extracts for the Treatment of Respiratory Allergies

2021 ◽  
Vol 36 (3) ◽  
Author(s):  
Ji-Ho Lee ◽  
Jae-Hwa Choi ◽  
Keun-Bae Jeong ◽  
Seok Jeong Lee ◽  
Myoung Kyu Lee ◽  
...  
Keyword(s):  
Respiratory Allergies ◽  
Rush Immunotherapy ◽  
Allergen Extracts
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