scholarly journals Synthesis of Dynamic 2-Ethoxycarbonyl-4H-3, 1-Benzoxazin-4-one and its Behavior Towards Nitrogen Nucleophiles

2008 ◽  
Vol 4 (3) ◽  
pp. 548-553 ◽  
Author(s):  
M. A. El-Hashash ◽  
Yaser Abdel-Moemen El-Badry
Keyword(s):  
Formic Acid ◽  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Mass Spectroscopy ◽  
Acid Hydrazide ◽  
Aromatic Aldehydes ◽  
Glucosamine Hydrochloride ◽  
Ft Ir ◽  
Nitrogen Nucleophiles

The behavior of  2-ethoxycarbonyl-4H-3,1-benzoxazin-4-one and its behavior towards nitrogen nucleophiles namely, hydrazine hydrate, formamide, benzylamine, ethylamine, piperidine, ethanol amine, o-phenylenediamine, and glucosamine hydrochloride has been investigated. Also the reaction of 3-[aminoquinazolin-4(3H)-one-2-yl]formic acid hydrazide with aromatic aldehydes and phenylisothiocyanate has been discussed. The structure of the prepared compounds are elucidated using physical and spectral data like, FT-IR, 1HNMR, and mass spectroscopy.

Synthesis, Characterization and Application of N,N-Dimethyl-N-Sulfoethan Ammonium tetra-Chloro Aluminate: A Novel micro-Heterogeneous Cata-lyst for Synthesis of tri-Arylmethanes

2020 ◽  
Vol 17 ◽  
Author(s):  
Saeid Azimi ◽  
Niloofar Mohamadighader
Keyword(s):  
Ionic Liquid ◽  
Heterogeneous Catalyst ◽  
Mass Spectroscopy ◽  
Aromatic Aldehydes ◽  
Solid Catalyst ◽  
Sem Images ◽  
One Pot ◽  
Acidic Catalyst ◽  
Eds Analysis ◽  
Ft Ir

Abstract: A new solid catalyst was synthesized from an ionic liquid and heterogenised by changing anion reaction. The new heterogeneous acidic catalyst was characterized by SEM images, EDS analysis, AFM images, Ft-IR, HNMR, 13CNMR and Mass Spectroscopy. It was applied to synthesis of tri-arylmethanes throughout one-pot tri-component reactions among aromatic aldehydes, N,N-dimethylaniline and other carbonic nucleophiles such as anisole and indole. Hence, synthesis of convenient and inexpensive micro-heterogeneous catalyst was introduced, the efficiency of which was confirmed. Also, various useful products were synthesized throughout this simple and clean procedure.

scholarly journals Antimicrobial Screening of Synthesized some Novel Azomethines via Organic Base

2015 ◽  
Vol 43 ◽  
pp. 26-33
Author(s):  
G.R. Patel ◽  
J.J. Maru ◽  
Rakesh Yadav
Keyword(s):  
Acetic Acid ◽  
Mass Spectroscopy ◽  
Elemental Analysis ◽  
New Products ◽  
Acid Hydrazide ◽  
Catalytic Amount ◽  
Organic Base ◽  
Antibacterial Effects ◽  
Gram Negative ◽  
Ft Ir

The author has synthesized azomethines in which carbonyl group is replaced by amine of acid hydrazides. The intermediates were prepared by using 2-mercapto benzimidazole with N-(4-Acetyl-phenyl)-2-chloro-acetamide in the presence of K2CO3. The Resulted product was further treated with different substituted of acid hydrazide in ethanol to yield the titled compounds using a catalytic amount of acetic acid. New products were examined for their antibacterial effects against Gram-positive and Gram-negative strains and antifungal were highly potent with lowest MIC Values. The structural assignments of the new products were done on the basis of FT-IR, NMR, Mass spectroscopy and elemental analysis.

scholarly journals Synthesis, Characterization and Screening of Anti-tubercular activity of 2, 5-Disubstituted-1, 3, 4-Oxadiazole

2013 ◽  
Vol 1 (03) ◽  
pp. 12-19
Author(s):  
Alex Martin
Keyword(s):  
Spectral Analysis ◽  
Carboxylic Acid ◽  
Microwave Irradiation ◽  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Acid Hydrazide ◽  
Mass Spectral Data ◽  
Furoic Acid ◽  
Mass Spectral ◽  
Phosphorous Oxychloride

The synthesis of 2-furyl-5-(substituted)-1,3,4-oxadiazoles was carried out by microwave irradiation of 2-furoic acid and ethanol followed by subsequent hydrazinolysis with hydrazine hydrate. Finally furan-2-acid hydrazide was treated with appropriate carboxylic acid in the presence of phosphorous oxychloride to produce title compounds. The structures of the newly synthesized compounds were established on the basis of spectral analysis such as IR, H1NMR and Mass spectral data. The synthesized compounds were screened for their anti-tubercular activity.

scholarly journals Synthesis and Characterization of some new Ibuprofen Derivatives and Study Antibacterial Activity

2020 ◽  
Vol 10 (03) ◽  
pp. 454-458
Author(s):  
Khalida A. Thejeel
Keyword(s):  
Antibacterial Activity ◽  
Acetyl Chloride ◽  
Acid Hydrazide ◽  
Aromatic Aldehydes ◽  
Secondary Amines ◽  
Schiff’S Base ◽  
E Coli ◽  
Aldehydes And Ketones ◽  
Ft Ir

The series of ibuprofen compounds (1–5) have been synthesized. Acid chloride (4-isobutylphenyl) acetyl chloride (1) was obtained from interaction ibuprofen with thionyl chloride, this compound (1) was treated with hydrazine to give acid hydrazide 2-(4-isobutylphenyl) acetohydrazide (2). Schiff’s base of 2-(4-isobutylphenyl) acetohydrazide derivatives (3a–e) were prepared by refluxing (2) with different aromatic aldehydes and ketones. The (4-isobutylphenyl) acetyl chloride (1) converts to esters (4a–f) by reacting with alcohols, and with secondary amines to give amide compounds of (4-isobutylphenyl) acetyl chloride (5a–b). All structures of synthesized compounds have been confirmed by elemental analysis (C, H, and N) and spectral data (FT-IR and 1H NMR). The prepared compounds (3a–e) and (4a–f) have been screened for their antibacterial activity for S. aureus, B. subtilis, E. coli, P. aeuroginosa, and were shown to have antibacterial activity.

scholarly journals Synthesis and Antimicrobial Activity of Some 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl- 1H-imidazolin-5(4H)-one Compounds

2019 ◽  
Vol 35 (2) ◽  
pp. 822-828
Author(s):  
Cong Tien Nguyen ◽  
Dao Thi Hong Dinh ◽  
Thin Van Nguyen ◽  
Giang Duc Le ◽  
Hien Cao Nguyen
Keyword(s):  
Antimicrobial Activity ◽  
Hydrazine Hydrate ◽  
Spectral Data ◽  
1H Nmr ◽  
Aromatic Aldehydes ◽  
Antimicrobial Activities ◽  
Gram Negative Bacteria ◽  
Schiff’S Bases ◽  
Gram Negative ◽  
Schiff's Bases

4-Chlorobenzylidene-2-methyl-(4H)-oxazol-5-one, which were prepared from 4-chlorobenzaldehyde and acetylglycine in reaction with hydrazine hydrate in ethanol gave 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one. However, treatment of 4-chlorobenzylidene-2-methyl-(4H)-oxazol-5-one with hydrazine hydrate in pyridine yielded 3-(4-chlorophenyl)propanohydrazide. Reaction of 1-amino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-one with aromatic aldehydes gave eight corresponding Schiff’s bases namely 1-arylideneamino-4-(4-chlorobenzylidene)-2-methyl-1H-imidazolin-5(4H)-ones. The structure of the 3-(4-chlorophenyl)propanohydrazide and the imidazoline-5-one compounds was confirmed by IR, 1H-NMR and MS spectral data. The Schiff’s bases were tested for antimicrobial activities against several strains of Gram-positive, Gram-negative bacteria, molds and yeasts.

scholarly journals Synthesis, Anti-Bacterial and Anti-Fungal Evaluation of Pyrazoline Derivatives

2012 ◽  
Vol 9 (4) ◽  
pp. 1801-1809 ◽  
Author(s):  
Ashvin D. Panchal ◽  
Pravinkumar M. Patel
Keyword(s):  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
H Nmr ◽  
Fungal Activity ◽  
Amine Compounds ◽  
Anti Fungal ◽  
New Compounds

The Series of N-(5-(Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine compounds were prepared by reaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by different aromatic aldehydes and cyclization with hydrazine hydrate. The structures of new compounds were confirmed by IR and1H-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with the standard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activity compared to standard drugs.

scholarly journals Synthesis and characterization of some novel 1,2,4-triazoles, 1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents

2015 ◽  
Vol 65 (2) ◽  
pp. 117-132 ◽  
Author(s):  
Mohamed Reda Aouad ◽  
Mouslim Messali ◽  
Nadjet Rezki ◽  
Adeeb Al-Sheikh Ali ◽  
Alain Lesimple
Keyword(s):  
Hydrazine Hydrate ◽  
Schiff Bases ◽  
Antimicrobial Agents ◽  
Potassium Hydroxide Solution ◽  
Acid Hydrazide ◽  
Aromatic Aldehydes ◽  
Mass Spectral ◽  
H Nmr ◽  
Acidic Conditions

Abstract (1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2- thiol (1) with ethylbromobutyrate, followed by addition of hydrazine hydrate. Treatment of acid hydrazide 3 with carbon disulfide in an ethanolic potassium hydroxide solution gave the intermediate potassium dithiocarbazinate salt, which was cyclized to 4-amino-5-[(1,4,5-triphenylimidazol- -2-yl)thiopropyl]-2H-1,2,4-triazole-3-thione (4) in the presence of hydrazine hydrate. Condensation of compound 3 with alkyl/arylisothiocyanate afforded the corresponding 1-[4-(1,4,5-triphenylimidazol-2-ylthio)butanoyl]-4-alkyl/arylthiosemicarbazides (5-7), which upon refluxing with sodium hydroxide, yielded the corresponding 1,2,4-triazole - -3-thiols 8-10. Under acidic conditions, compounds 4-6 were converted to aminothiadiazoles 11-13. Moreover, the series of Schiff bases 14-18 were synthesized from the condensation of compound 3 with different aromatic aldehydes. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral analyses. They were also preliminarily screened for their antimicrobial activity.

Synthesis of 2-methyl-3-(5-phenyl or 1,5-diphenyl-2-pyrazolin-3-yl)-1,8-naphthyridines

1988 ◽  
Vol 53 (7) ◽  
pp. 1543-1548 ◽  
Author(s):  
Maringanti Thirumala Chary ◽  
Kaleru Mogilaiah ◽  
Bathula Sreenivasulu
Keyword(s):  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Fungicidal Activity ◽  
Aromatic Aldehydes ◽  
Elemental Analyses

3-Cinnamoyl-2-methyl-1,8-naphthyridines II have been synthesized utilizing Claisen-Schmidt condensation of 3-acetyl-2-methyl-1,8-naphthyridine I with aromatic aldehydes. The cinnamoyl naphthyridines react with hydrazine hydrate and phenylhydrazine to create the corresponding pyrazolinyl 1,8-naphthyridine derivatives (III and IV). The structures II-IV have been confirmed by their elemental analyses and spectral data. Some of the compounds have been screened for their fungicidal activity.

scholarly journals Synthesis and Characterization of New Polyimide Contain Heterocyclic

2013 ◽  
Vol 10 (4) ◽  
pp. 1203-1210
Author(s):  
Baghdad Science Journal
Keyword(s):  
Nucleophilic Substitution ◽  
Hydrazine Hydrate ◽  
Carbon Disulfide ◽  
13C Nmr ◽  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
Spectroscopic Methods ◽  
Synthetic Route ◽  
Ft Ir

Novel heterocyclic polyimide 5(a,b) have been synthesized based on polyacrylic backbone. The synthetic route start with nucleophilic substitution of 2-amino, or 4-amino, pyridine 1(a,b) to the polyacryloyl chloride afforded poly substituted amide 2(a,b). Another nucleophilic substitution were carried with adipoyl chloride to form polyimide chloride 3(a,b). Treatment of 3(a,b) with hydrazine hydrate afforded acid hydrazide polyimide 4(a,b), which upon cyclocondensation with carbon disulfide gave the target heterocyclic polyimide. The synthesized compounds were identified by spectroscopic methods: FT-IR, 1H-NMR and 13C-NMR.

scholarly journals Synthesis and Characterization of Novel Subs. -1,3,4-Thiadiazolependant on Modified Poly(5-Vinyl Tetrazole-Co-MA)

2020 ◽  
pp. 472-484
Author(s):  
Raghad Hamid ◽  
Intisar Obaid
Keyword(s):  
Hydrazine Hydrate ◽  
Methyl Acrylate ◽  
Carbon Disulphide ◽  
Acid Hydrazide ◽  
Synthesis And Characterization ◽  
Second Step ◽  
Chloroacetyl Chloride ◽  
Phenyl Hydrazine ◽  
Ft Ir

New polymers were prepared from a monomer (5-vinyl-1H-tetrazole), which was prepared from acrylonitrile with sodium azide in the presence of ZnCl2.Another monomer (Methyl acrylate) was also used. Co-monomers were polymerized usingBPO as initiator. The second step was the preparation of copoly acid hydrazide from the reaction of compound2 with hydrazine hydrate, followed by the reaction with carbon disulphide in the presence of KOH to obtain copoly (5-subs.-2-mercapto-1,3,4-thiadiazole). Next,compound4 was reacted with chloroacetyl chloride to yield compound4 5 which was reacted with (hydrazine hydrate , phenyl hydrazine and 2,4-di nitro phenyl hydrazine) as shown in scheme(1). Physical properties of all the prepared copolymers were characterized by FT-IR and, in certain cases,by1HNMR spectroscopy.

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