scholarly journals Synthesis, Anti-Bacterial and Anti-Fungal Evaluation of Pyrazoline Derivatives

2012 ◽  
Vol 9 (4) ◽  
pp. 1801-1809 ◽  
Author(s):  
Ashvin D. Panchal ◽  
Pravinkumar M. Patel
Keyword(s):  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
H Nmr ◽  
Fungal Activity ◽  
Amine Compounds ◽  
Anti Fungal ◽  
New Compounds

The Series of N-(5-(Substituted phenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine compounds were prepared by reaction of 4-amino-1,2,4-Triazole with Acetyl Chloride followed by different aromatic aldehydes and cyclization with hydrazine hydrate. The structures of new compounds were confirmed by IR and1H-NMR spectral data. Anti-bacterial and Anti-fungal activities were evaluated and compared with the standard drugs, some compounds of the series exhibited promising anti-microbial and anti-fungal activity compared to standard drugs.

scholarly journals Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones

2005 ◽  
Vol 2 (2) ◽  
pp. 109-112
Author(s):  
A. K. Parekh ◽  
K. K. Desai
Keyword(s):  
Antibacterial Activity ◽  
Spectral Data ◽  
Elemental Analysis ◽  
Aromatic Aldehydes ◽  
Gram Negative Bacteria ◽  
Gram Positive ◽  
Gram Negative ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
H Nmr

Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B. subtillis & S. aureus and Gram negative bacteria E. coli & S. typhi.

scholarly journals Synthesis ofN-(5-(Substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine from 4-Amino-4H-1,2,4-triazole

2011 ◽  
Vol 8 (3) ◽  
pp. 1180-1185
Author(s):  
Ashvin D. Panchal ◽  
Pravin M. Patel
Keyword(s):  
Thin Layer ◽  
Hydrazine Hydrate ◽  
Thin Layer Chromatography ◽  
Aromatic Aldehyde ◽  
Acetyl Chloride ◽  
Spectroscopic Studies ◽  
H Nmr ◽  
Ir Spectroscopic ◽  
Layer Chromatography

N-(4H-1,2,4-Triazol-4-yl)acetamide (2) were prepared by reaction of 4-amino-4H-1,2,4-triazole (1) with acetyl chloride in dry benzene. It has been reacted with various aromatic aldehyde to afford 3-(substitutedphenyl)-N-(4H-1,2,4-triazol-4-yl)acrylamide (3a-e). The synthesis ofN-(5-substitutedphenyl)-4,5-dihydro-1H-pyrazol-3-yl)-4H-1,2,4-triazol-4-amine (4a-e) is achieved by the cyclisation of3a-ewith hydrazine hydrate in ethanol. The structures of synthesized compounds were characterized by1H NMR and IR spectroscopic studies. The purity of the compounds was checked by thin layer chromatography.

scholarly journals SYNTHESIS OF SOME NOVEL TRIAZOLE DERIVATIVES AS SCHIFF BASES AND THEIR ANTIMICROBIAL EVALUATION

2016 ◽  
Vol 8 (9) ◽  
pp. 28
Author(s):  
Vaibhav Sharma ◽  
Dinesh Kumar Mehta ◽  
Rina Das ◽  
Preet Kawal Kaur
Keyword(s):  
Schiff Base ◽  
Benzoic Acid ◽  
Analytical Techniques ◽  
Aromatic Aldehydes ◽  
Gram Positive ◽  
Gram Negative ◽  
H Nmr ◽  
Schiff Base Derivatives ◽  
Weak Activity ◽  
Anti Fungal

<p><strong>Objective: </strong>This work involves the synthesis of some novel schiff base derivatives synthesized from <em>p-</em>amino benzoic acid.</p><p><strong>Methods: </strong>A series of 4-[4-(arylidene amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl]-benzoic acid complexes were synthesized from 4-(4-amino-5-mercapto-4H-[1, 2, 4] triazol-3-yl)-benzoic acid by reaction with different aromatic aldehydes. All the synthesized schiff base derivatives were characterized by using analytical techniques (FT-IR, <sup>1</sup>H NMR and Mass spectroscopy). The title compounds were evaluated for antibacterial activity against Gram-positive bacteria (<em>Staphylococcus aureus </em>and <em>Streptococcus pneumoniae) </em>and Gram-negative bacteria (<em>Escherichia coli and Pseudomonas aeruginosa)</em> and anti-fungal activity against (<em>Candida albicans </em>and <em>Aspergillus niger).</em></p><p><strong>Results: </strong>Schiff base derivatives 5(a-h) were synthesized in good yields and showed antimicrobial activity, among them, compounds 5c, 5d, 5e and 5f were significantly active against gram positive, gram negative bacterial and fungal strains and rest of compounds showed moderate to weak activity.</p><p><strong>Conclusion: </strong>The Schiff base obtained showed variation in the antimicrobial and antifungal activity, based on the structure of the substituted aromatic aldehydes.</p>

New phthalocyanines containing bulky electron rich substituents

2009 ◽  
Vol 13 (06) ◽  
pp. 753-759 ◽  
Author(s):  
İbrahim Özçeşmeci ◽  
Orhan Güney ◽  
Ali İhsan Okur ◽  
Ahmet Gül
Keyword(s):  
Energy Transfer ◽  
Metal Ions ◽  
Spectral Data ◽  
Electronic Spectra ◽  
Fluorescence Spectra ◽  
Radiative Decays ◽  
Metal Free ◽  
H Nmr ◽  
Elemental Analyses ◽  
New Compounds

Metal-free and metallophthalocyanines with four 9-anthroyl groups bound through ethylthio ester bridges on the periphery have been prepared. The new compounds were characterized by elemental analyses, 1 H NMR, IR, mass and UV-vis spectral data. The electronic spectra exhibit an intense π-π* transition of 9-anthroyl identity together with characteristic Q and B bands of the phthalocyanine core. Effect of metal ions on intensity of fluorescence spectra of phthalocyanine derivatives substituted with 9-anthroyl groups was investigated. The energy transfer to the phthalocyanine core and radiative decays of the 9-anthroyl emission and phthalocyanine core were examined.

Partially oxidized porphyrazines

2006 ◽  
Vol 10 (07) ◽  
pp. 996-1002 ◽  
Author(s):  
Ayhan Nazli ◽  
Ergün Gonca ◽  
Ahmet Gül
Keyword(s):  
Spectral Data ◽  
Elemental Analysis ◽  
Trifluoroacetic Acid ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Ft Ir ◽  
New Compounds

Magnesium porphyrazinate substituted with eight (1-naphthyl) groups on the peripheral positions has been synthesized by cyclotetramerization of 3,4-(1-naphthyl)pyrroline-2,5-diimine, 4-(1-naphthyl)pyrroline-2,5-diimine in the presence of magnesium butanolate. Its demetalation by treatment with trifluoroacetic acid, resulted in a partially oxidized product, namely, octakis(1-naphthyl)-2-seco-porphyrazine-2,3-dione. Further reaction of this product with copper(II) acetate, zinc(II) acetate and cobalt(II) acetate led to the metallo derivatives, [octakis(1-naphthyl)-2-seco-2,3-dioxoporphyrazinato]M(II) ( M = Cu , Zn or Co ). These new compounds have been characterized by elemental analysis, together with FT-IR, 1 H NMR, UV-vis and mass spectral data.

scholarly journals Synthesis and Antifungal Activities of 5-(o-Hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole

2011 ◽  
Vol 8 (2) ◽  
pp. 594-597 ◽  
Author(s):  
Shiv K. Gupta ◽  
P. K. Sharma ◽  
M. Bansal ◽  
B. Kumar
Keyword(s):  
Antifungal Activity ◽  
Spectral Data ◽  
Antifungal Activities ◽  
H Nmr ◽  
New Compounds

New series of 5-(o-hydroxy phenyl)-2-[4'aryl-3'chloro-2'azetidinon-1-yl]-1,3,4-thiadiazole have been synthesized and the structures of the new compounds were established on the basis of IR,1H NMR spectral data.In vitroantifungal activity (MIC activity) was evaluated and compared with standard drugs of ketoconazole. Compounds3cin the series has shown interesting antifungal activity against bothC. albicansandA. nigerfungus. In the gratifying result, most of the compounds were found to have moderate antifungal activity.

scholarly journals Synthesis of Some New Pyrrolo Heterocycles of Pharmaceutical Interest from 1,4-Diphenylpyrrolidine-2,3,5-trione+

1990 ◽  
Vol 45 (3) ◽  
pp. 382-384 ◽  
Author(s):  
Mohamed Abbas Metwally ◽  
M. A. Sofan
Keyword(s):  
Hydrazine Hydrate ◽  
Spectral Data ◽  
Mass Spectra ◽  
Structural Identification ◽  
H Nmr ◽  
Pharmacological Interest ◽  
Derivatives Of

Continuing earlier studies designed to obtain derivatives of pharmacological interest, some novel compounds 2, 5, 6, 7 and 8 were prepared using 1,4-diphenylpyrrolidine-2,3,5-trione (1) and 1,2-phenylenediamines, o-aminophenol, 1,3-diphenylacetone and thiosemicarbazide, respectively. The hydrazino derivative (8) was obtained from 7 and hydrazine hydrate. Structural identification was obtained by 1H NMR, mass spectra and IR spectral data.

scholarly journals Microwave-Assisted Synthesis of Arylidene Acetophenones

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Sheauly Khatun ◽  
M. Z. H. Khan ◽  
Khodeza Khatun ◽  
M. A. Sattar
Keyword(s):  
Microwave Irradiation ◽  
Microwave Heating ◽  
Spectral Data ◽  
Condensation Reaction ◽  
Aromatic Aldehydes ◽  
Conventional Heating ◽  
Microwave Assisted Synthesis ◽  
Efficient Synthesis ◽  
H Nmr ◽  
Microwave Assisted

An efficient synthesis of arylidene acetophenones have been achieved by using the microwave heating in comparison to the conventional heating. In this work compound 1-phenyle-3-(4-droxyphenyle)-2-propen-1-one, 1-(4-chlorophenyle)-3-phenyle-2-propen-1-one, and 1-(4-chlorophenyle)-3-(4-hydroxyphenyle)-2-propen-1-one have been synthesized by the condensation reaction between aromatic aldehydes and substituted acetophenones under microwave irradiation. The compounds of aldehydes and acetophenones were used as benzaldehyde, parahydroxybenzaldehyde, acetophenone, and parachloroacetophenone. The result shows that the time taken for the reaction was reduced from the conventional 1-2 hours to 60–120 seconds. The yield of the compounds in the conventional heating was moderate while the highest yield of 90–98% was observed in MWI method. The structure of the compounds was characterized by their IR,1H-NMR spectral data.

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES

INDIAN DRUGS ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 40-44
Author(s):  
.Aishwarya T.C ◽  
◽  
James Jainey ◽  
Vijay Kumar M. ◽  
B.C. Revanasiddappa
Keyword(s):  
Spectral Data ◽  
Anticonvulsant Activity ◽  
Aromatic Aldehydes ◽  
Oxidative Cyclization ◽  
Mercuric Oxide ◽  
Mass Spectral Data ◽  
Mass Spectral ◽  
H Nmr ◽  
Oxadiazole Derivatives

2 Oxo-2h-chromene-3-carbohydrazide (1) reacts with various aromatic aldehydes to give corresponding 2-oxo-2h-chromene-3-carbohydrazide arylidene hydrazides (SB1-8). Oxidative cyclization of (SB1-8) with mercuric oxide and iodine in DMF medium furnishes the title compounds 3-(5-aryl-1,3,4-oxadiazol2-yl)-2h-chromen-2-ones (2a-h). All the synthesized compounds were assigned structures on the basis of IR, 1 H-NMR and Mass spectral data. Some of the selected compounds were evaluated for In vivo anticonvulsant activity by MES and PTZ models.

scholarly journals Microwave Assisted Synthesis of N-Substituted-7-hydroxy-4-methyl-2-oxoquinolines as Anticonvulsant Agents

2011 ◽  
Vol 8 (2) ◽  
pp. 945-951 ◽  
Author(s):  
P. Y. Pawar ◽  
P. M. Gaikwad ◽  
P. H. Balani
Keyword(s):  
Microwave Irradiation ◽  
Anticonvulsant Activity ◽  
Acetyl Chloride ◽  
Aromatic Aldehydes ◽  
Analysis Data ◽  
Microwave Assisted Synthesis ◽  
Elemental Analysis Data ◽  
H Nmr ◽  
Microwave Assisted ◽  
Coumarin 1

The reaction of resorcinol with ethylacetoacetate yielded the 7-hydroxy-4-methyl coumarin (1), which on treatment with benzidine gives 1-(4ʹ-amino-biphenyl-4-yl)-7-hydroxy-4-methyl-1H-quinolin-2-one (2). 1-{4ʹ-[(Substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (3a-j) were obtained by reacting 1-(4ʹ-amino-biphenyl-4-yl)-7-hydroxy-4-methyl-1H-quinolin-2-one (2) with different substituted aromatic aldehydes in presence of glacial acetic acid by microwave irradiation. The compound 1-{4ɴ-[(substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (3a-j) on cyclization with chloro acetyl chloride in presence of triethylamine as catalyst under microwave irradiation furnished 1-{4ʹ-[3-chloro-2-(substituted phenyl)-4-oxo-azetidin-1-yl]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (4a-j). Purity of synthesized compounds was checked by TLC and the structures were elucidated by their IR,1H NMR, Mass and elemental analysis data. The synthesized compounds were screened for anticonvulsant activity.

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