scholarly journals Antiviral and anti-inflammatory effects of medicated thread moxibustion combined with Shujin Jiannao granule in the treatment of HFMD

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Yue Yan Huang
Keyword(s):  
Western Medicine ◽  
Combined Treatment ◽  
Clinical Effectiveness ◽  
Serum Levels ◽  
Normal Control Group ◽  
Control Group ◽  
Healthy Children ◽  
Effectiveness Rate ◽  
Anti Inflammatory ◽  
Experimental Group

Objective To investigate antiviral and anti-inflammatory effects of medicated thread moxibustion combined with Shujin Jiannao granule in the treatment of HFMD. Methods A total of 124 children with HFMD were collected to divided into western medicine group (62 cases) and experimental group(62 cases) while 62 healthy children were enrolled to become normal control group. Western medicine group was treated according to conventional therapy while experimental group was treated with combined treatment of traditional Chinese medicine(TCM) and western medicine. To determine serum levels of S100B, NSE, CRP and WBC and observe the clinical effectiveness. Results In the western medicine group the total effectiveness rate is 88.7% while it is 96.8% in the experimental group（P<0.05）; the average disappearance time of symptoms are shorter in the experimental group than that in the western medicine group（P<0.05）. Compared with the control group，the serum levels of S100B, NSE, CRP and WBC all rise in HFMD children（P<0.05 or P<0.01）. After treatment , the serum levels of S100B, NSE, CRP and WBC reduce in both the experimental group and the western medicine group, when compared with that before treatment.The difference is statistically significant（P<0.05 or P<0.01）. 

scholarly journals NEW APPROACHES TO POSTOPERATIVE TREATMENT PERITONITIS

2020 ◽  
Vol 19 (4) ◽  
pp. 43-46
Author(s):  
V. Maksymyuk ◽  
M. Sheremet
Keyword(s):  
Inflammatory Cytokines ◽  
Tissue Damage ◽  
Postoperative Treatment ◽  
Antioxidant Systems ◽  
Control Group ◽  
Septic Complications ◽  
Antigenic Properties ◽  
Anticytokine Therapy ◽  
Anti Inflammatory ◽  
Experimental Group

A significant role in the pathogenesis of peritonitis is attributed to free radical mechanisms of tissue damage. Due to inhibition of a number of membrane-bound enzymes and FRO of lipids of plasma membranes, foci of secondary necrosis appear in the peritoneum. Oxidized lipids have antigenic properties, and therefore stimulate autoimmune processes of tissue damage. In the pathogenesis of peritonitis, an important role is played by inflammatory mediators - cytokines. Their biological activity is manifested by the action on highly specific receptors located on cells. At the same time, interleukins and tumor necrosis factor act on all cells, exhibiting a systemic effect. It was found that the activity of ceruloplasmin in the blood plasma of patients in the control group progressively decreased from the first to the fifth day of the postoperative period, from 77.2 ± 5.61 to 59.32 ± 4.42 o.o. / g of protein, and in the patients of the experimental group it increased highly reliably - from 77.2 ± 5.61 to 97.31 ± 4.42 o.o. / h protein (p <0.001). The same pattern is characteristic of catalase activity. The activity of glutathione peroxidase in patients of both groups significantly decreased up to 3 days after the operation and increased on the fifth day, and it was more pronounced in the patients of the experimental group. When studying the level of cytokines, it was found that the expression of proinflammatory cytokines IL-1b, IL-8, TNFa exceeded the control values, while the expression of anti-inflammatory cytokines IL-1Ra was "delayed" (almost twofold). The highest expression of IL-1b, IL-8 potentiated further chain of pro-inflammatory reactions indicates the adequacy of the anti-inflammatory response and the relative balance between pro-inflammatory and anti-inflammatory cytokines and the adequacy of anticytokine therapy. The total number of septic complications (PBS) in the control group was 82.4%, and in the experimental group it was 66.7%. In dynamics study of pro- and antioxidant systems and serum concentra-tions of cytokine in the patients with acute peritonitis was high prognostic significance of results this study, which allows defining treatment tactic of these patients. To include in complex post-operative treatment of these pa-tients with evaluated antioxidant and anticytokine therapy allowed reducing the development of purulent-septic complications from 82.4 to 66.7%, which increased effectively of treatment in such patients and reduced the term of hospitality.

Low Oxygen Tension and Discrimination Reversal

1969 ◽  
Vol 29 (2) ◽  
pp. 415-424
Author(s):  
Ralph Gunter ◽  
Edwin T. Wright ◽  
W. Jann Brown ◽  
Eleanor R. Gunter
Keyword(s):  
Oxygen Deprivation ◽  
Normal Control Group ◽  
Control Group ◽  
Low Oxygen ◽  
Observable Effect ◽  
Form Discrimination ◽  
Reversal Performance ◽  
Learning Group ◽  
New Learning ◽  
Experimental Group

An experimental group of 9 cats were trained to a visual form discrimination; the valences of the stimuli were then reversed and the cats were subjected to various levels of oxygen deprivation after which they were tested for retention and reversal performance. A normal control group ( N = 9) were trained identically to the experimental group but were not subjected to hypoxia. 10 naive cats constituted the post-hypoxia new-learning group. It was found that 70 min. of oxygen deprivation had a significant effect on retention and reversal performance; one exposure had no observable effect on either function. No differential effects were found on retention or new learning as measured by either retention new-learning or reversal-reversal comparisons.

Study on mechanism of Tim-3 on immune escape in benzene-induced acute myeloid leukemia

2020 ◽  
Author(s):  
qiong Ning ◽  
xiangxin li ◽  
Xiangdong Jian ◽  
Xiaopeng He
Keyword(s):  
Bone Marrow ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Immune Escape ◽  
Serum Levels ◽  
Control Group ◽  
M2 Macrophages ◽  
Experimental Group ◽  
Group Serum ◽  
Acute Myeloid

Abstract To study the mechanism of Tim-3 on immune escape in benzene-induced acute myeloid leukemia (AML), to provide potential targets of clinical monitoring and intervention of hematological toxicity in benzene-induced AML . C3H/He mice were randomly divided into control group and experimental group. Serum levels of IL-12 in the experimental group were significantly lower than that in the control group. Serum levels of TGF-β1 in the experimental group were significantly higher than that in the control group( p <0.05). The proportion of Tim-3 positive CD14 + monocytes of bone marrow and spleen in the experimental group were both significantly higher than that in the control group ( p <0.05) by Flow cytometry (FCM). Compared with the control group, the expression of Tim-3 on (M1+M2) macrophages of bone marrow in the experimental group significantly increased by immunofluorescence assay. The expression of type M2 macrophages in (M1+M2) macrophages of bone marrow and spleen tissues in the experimental group were both higher than that in the control group. The expression levels of p-PI3K, p-AKT and p-mTOR in the experimental group were all significantly higher than that in the control group. Tim-3 was highly expressed in macrophages in benzene-induced AML. It promoted the activation of PI3K/AKT/mTOR signaling pathway, stimulated the secretion of anti-inflammatory cytokines, and inhibited the secretion of pro-inflammatory cytokines. High expression of Tim-3 changed the phenotype and function of macrophages by promoting the macrophages polarization, thus inducing negative immune response in the tumor microenvironment and tumor immune escape.

scholarly journals Da-Cheng-Qi Decoction Combined with Conventional Treatment for Treating Postsurgical Gastrointestinal Dysfunction

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Jin ◽  
Qingjie Li ◽  
Xiaoqiong Luo ◽  
Juan Zhong ◽  
Yang Song ◽  
...  
Keyword(s):  
Western Medicine ◽  
Group Intervention ◽  
Methodological Quality ◽  
Data Extraction ◽  
Test Group ◽  
Clinical Effectiveness ◽  
Effective Rate ◽  
Control Group ◽  
Gastrointestinal Dysfunction ◽  
Outcome Index

Aim. To assess the current clinical evidence of the effectiveness of Da-Cheng-Qi Decoction (DCQD) for the treatment of Postoperative gastrointestinal dysfunction (PGD).Methods. Randomized controlled trails (RCTs) of Da-Cheng-Qi Decoction (DCQD) to PGD were searched from available major electronic databases to September 2016. The intervention must be a modified DCQD or DCQD integrated to Western Medicine (WM) compared with WM or placebo or blank. The main outcome index was clinical effectiveness and improvement of major symptoms. Data extraction, data analysis, and methodological quality assessment are conducted according to the Cochrane Handbook for Systematic Review of Interventions, version 5.0.2. RevMan 5.3 software was applied to our data analyses.Results. Seven RCTs involving 494 participants were recruited and identified. The methodological quality of all trials were assessed and generally of low-level. Those studies were published between 2004 and 2013. All 7 studies which used herbals (modified DCQD) integrate WM in test group compared with WM as the intervention and only one study (Sunyouxu 2013) integrates placebo to Western Medicine as the control group intervention. The treatment course was 1 week to 2 weeks. Evaluation of intervention effectiveness consists of the clinical effective rate indicator and the PGD symptoms indicator including time of borborygmus, time of gastrointestinal exhaust, and time of defecate. The clinical effectiveness results are beneficial to the test group.Conclusion. DCQD could improve PGD symptoms and promotion clinical effectiveness.

Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: A 5-year controlled clinical trial

2014 ◽  
Vol 29 (3) ◽  
pp. 134-141 ◽  
Author(s):  
A. González Isasi ◽  
E. Echeburúa ◽  
J.M. Limiñana ◽  
A. González-Pinto
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Behavioral Therapy ◽  
Pharmacological Treatment ◽  
Behavioral Therapy ◽  
Combined Treatment ◽  
Control Group ◽  
Time Points ◽  
Evaluation Time ◽  
Experimental Group

AbstractObjective:The aim of this research, which represents an additional and longer follow-up to a previous trial, was to evaluate a 5-year follow-up study of a combined treatment (pharmacological + psychoeducational and cognitive-behavioral therapy) as compared with a standard pharmacological treatment in patients with refractory bipolar disorder.Method:Forty patients were randomly assigned to either an Experimental group–under combined treatment — or a Control group — under pharmacological treatment. Data were analyzed by analysis of variance (ANOVA), with repeated measures at different evaluation time points.Results:Between-group differences were significant at all evaluation time points after treatment. Experimental group had less hospitalization events than Control group in the 12-month evaluation (P = 0.015). The Experimental group showed lower depression and anxiety in the 6-month (P = 0.006; P = 0.019), 12-month (P = 0.001; P < 0.001) and 5-year (P < 0.001, P < 0.001) evaluation time points. Significant differences emerged in mania and misadjustment already in the post-treatment evaluation (P = 0.009; P < 0.001) and were sustained throughout the study (6-month: P = 0.006, P < 0.001; 12-month: P < 0.001, P < 0.001; 5-year: P = 0.004, P < 0.001). After 5-year follow-up, 88.9% of patients in the Control group and 20% of patients in the Experimental group showed persistent affective symptoms and/or difficulties in social-occupational functioning.Conclusions:A combined therapy is long-term effective for patients with refractory bipolar disorder. Suggestions for future research are commented.

scholarly journals Qing Re Liang Xue Decoction Alleviates Hypercoagulability in Kawasaki Disease

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Jiao-yang Chen ◽  
Ji-ming Yin ◽  
Zhong-dong Du ◽  
Jing Hao ◽  
Hui-min Yan
Keyword(s):  
Treatment Group ◽  
Kawasaki Disease ◽  
Integrative Medicine ◽  
Western Medicine ◽  
Control Group ◽  
Healthy Children ◽  
Protective Effects ◽  
Laboratory Findings ◽  
Necrosis Factor Alpha ◽  
Interleukin 33

Objective. Kawasaki disease (KD) is a multisystemic autoimmune vasculitis. Intravenous immunoglobulin (IVIG) is the first-line treatment for KD. It is unclear whether traditional Chinese medicine (TCM) has an effect on KD. We aimed to observe the clinical efficacy of TCM on acute KD via serum interleukin-33 (IL-33) and tumor necrosis factor alpha (TNF-α) measurements.Methods. Thirty-one KD patients were treated with Qing Re Liang Xue decoction and Western medicine (integrative medicine treatment group), while 28 KD patients were treated with Western medicine only (Western medicine treatment group). Thirty patients were included in a febrile group and 28 healthy children were included in the control group. Clinical characteristics and laboratory findings were gathered and compared. Serum IL-33 and TNF-αlevels were measured by multiplex Luminex assay.Results. The platelet count in the integrative medicine treatment group was significantly lower than that in the Western medicine treatment group. The integrative medicine group had a shorter fever duration and lower IL-33 and TNF-αlevels than those in the Western medicine group, but there were no significant differences between the two KD groups after treatment.Conclusion. Qing Re Liang Xue decoction improved the hypercoagulable state of KD patients. Potential myocardial protective effects require further research.

scholarly journals PO-118 Effects of field-battle hypoxia supporter on free radical metabolism after exercise at high altitude

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Taobo Liu
Keyword(s):  
Free Radical ◽  
High Altitude ◽  
Serum Levels ◽  
Control Group ◽  
Free Radical Damage ◽  
Oxygen Inhalation ◽  
Total Antioxidant ◽  
Radical Damage ◽  
Experimental Group ◽  
Free Radical Metabolism

Objective To explore the effects of field-battle hypoxia supporter on free radical metabolism after exercise at high altitude． Methods A total of 40 healthy fighters stationed in the 3800m plateau for 10 days were randomly divided into two groups. Each group of 20 men, armed with heavy weapons and hypoxia supporter, hiked 5 km and then climbed a 4,300 m peak, a total distance of 10 km. The control group closed the valve of hypoxia supporter without oxygen inhalation, the experimental group opened the valve and inhaled oxygen. The serum levels of superoxide dismutase(SOD), total antioxidant capacity(T-AOC), reactive oxygen species (ROS) and malondialdehyde (MDA) were measured at rest and after exercise. In addition, The average marching speed of the two groups were compared． Results The T-AOC, ROS and MDA were increased both in the control group and experimental group after exercise, and the SOD increased significanly in experimental group (P<0.01)．Compared with control group, the SOD and T-AOC were increase but the ROS and MDA were decreased significanly after exercise(P<0.01)．The average speed of 10km cross-country march in the control group and the experimental group was (3.0±0.3)km/h and (2.3±0.5)km/h respectively, and there were significant differences (P<0.01). Conclusions The field-battle hypoxia supporter can restrain free radical damage after exercise at high altitude and increase the efficiency of work at high altitude. Acknowledgements: This work was supported by the Guangdong Science and Technology Equipment Mobilization project (Research and application of field-battle hypoxia supporter).  

scholarly journals Analysis of Intestinal Flora and Levels of Epidermal Growth Factor Receptor, Interleukin-32, and Gastrin 17 in Patients with Gastric Cancer via Carbon Nanoparticle Laparoscopy

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Liping Bai ◽  
Fubing Yu ◽  
Lixian Bai ◽  
Yinhui Zhang ◽  
Zhi Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Intestinal Flora ◽  
Growth Factor Receptor ◽  
Serum Levels ◽  
Control Group ◽  
Carbon Nanoparticle ◽  
Laparoscopic Operation ◽  
Distal Gastric Cancer ◽  
Experimental Group

In order to explore the changes of intestinal flora and serum levels of relevant substances in patients with gastric cancer before and after surgery with carbon nanoparticle laparoscopy, a total of 180 patients with early distal gastric cancer who adopted laparoscopic radical gastrectomy for distal gastric cancer in the general surgery department of TCM Hospital of Shi Jia Zhuang City from January 2018 to January 2020 were selected and randomly divided into two groups: traditional laparoscopic operation (control group) and carbon nanoparticle laparoscopic operation (experimental group) were adopted for treatment for the two groups, respectively. Postoperative evaluation included the difference between the two groups in the operative time, the efficiency of intraoperative lymph node dissection, and the number of lymph node detection. The adverse reactions, changes of intestinal flora before and after surgery in the two groups, and the serum levels of epidermal growth factor receptor (EGFR), interleukin-32 (IL-32), and gastrin 17 were evaluated. In the experimental group, the success rate of carbon nanoparticle tracer black staining reached 100%, and the operation time of the experimental group was significantly shorter than that of the control group ( P < 0.05 ). The lymph node detection rate of the experimental group was higher than that of the control group ( P < 0.05 ), but there was no significant difference in the lymph node metastasis rate between the two groups ( P > 0.05 ). The sentinel lymph node sensitivity of the experimental group reached 92.3%, and the specificity, accuracy, and positive and negative prediction rates reached 100%; the experimental group patients were with an obviously higher incidence of level I-II gastrointestinal reaction ( P < 0.05 ). Postoperative increases in Bifidobacteria and Lactobacillus were observed in both groups, while decreases in Enterococcus and Escherichia coli were observed in both groups ( P < 0.05 ). Moreover, the degree of increase and decrease in the experimental group was greater than that in the control group ( P < 0.05 ). The serum levels of EGFR, IL-32, and gastrin 17 in the two groups were significantly lower than those in the control group on 3 d, 7 d, and 15 d after surgery ( P < 0.05 ). In the radical gastrectomy for distal gastric cancer, carbon nanoparticle laparoscopy was not only helpful for the localization of small tumors but also for the thorough dissection of lymph nodes after the surgery, and the postoperative adverse reactions of carbon nanoparticle laparoscopy were also less, which was of great significance for the improvement of intestinal flora and the reduction of serum levels of EGFR, IL-32, and gastrin 17 in gastric cancer patients.

scholarly journals Immunomodulatory and Anti-Inflammatory Potentials of Trigona Honey in the Therapy and Prevention against Respiratory Infection in Wistar Rats

2020 ◽  
Vol 11 (3) ◽  
pp. 2955-2962
Author(s):  
Ibrahim Khaled Al-kafaween ◽  
Abu Bakar Mohd Hilmi ◽  
Mohamed M. Soliman
Keyword(s):  
Respiratory Infection ◽  
Wistar Rats ◽  
Serum Levels ◽  
Negative Control Group ◽  
Treated Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Gene Expressions ◽  
Anti Inflammatory

Trigona honey (TH) is well known for its therapeutic characteristics. To date, the study of Trigona honey as a prophylactic or immune booster prior to the bacterial infection of the invivo model is not well covered. This study aims to investigate anti-inflammatory and immune activities in Wistar rats infected with respiratory infection following with Trigona honey. 25 Wistar rats were assigned to possitive groups, negative control group, positive control group was fed TH (5 g / kg body weight) orally, the untreated group was infected with Staphylococcus aureus to induce respiratory infection, the treated group has been infected with S. aureus followed by treatment with TH at a dose of 1.5 ×108 CFU / mL and the preventive group ingested TH one week before S. aureus infection. Blood was obtained for biochemical analysis. Lung tissues have been collected for molecular examination. The results showed a significant decrease in serum levels of ALT, AST, urea and creatinine in the preventive and treated groups, serum IgG increased significantly (P<0.05) in the preventive and treated groups, IFN-y increased in the preventive group while decreased in the treated group, and IL-8 increased in the treated group while decreased in the preventive group. The mRNA expression of AGP is up-regulated in the positive control, preventive and treated groups. The α2-MG, TNF-α , and mRNA expressions showed lower regulation after administration of TH in preventive and treated groups. The results show the ability of TH to counteract immune and inflammatory changes in serum levels and gene expressions.

scholarly journals Ketoprofen as an Add-on Treatment to Sertraline for Drug-Naïve Major Depressed Patients: Normalization of Plasma Levels of Indoleamine-2,3-Dioxygenase in Association with Pro-Inflammatory and Immune Regulatory Cytokines

2018 ◽  
Author(s):  
Hussein Al-Hakeim ◽  
Ahmed Jasim Twayej ◽  
Arafat Hussein Al-Dujaili ◽  
Michael Maes
Keyword(s):  
Clinical Efficacy ◽  
Transforming Growth Factor ◽  
Inflammatory Responses ◽  
Serum Levels ◽  
Future Research ◽  
Control Group ◽  
Clinical Effects ◽  
Indoleamine 2,3 Dioxygenase ◽  
Anti Inflammatory ◽  
Normal Controls

Major Depression Disorder (MDD) is accompanied by an immune response characterized by increased levels of pro-inflammatory and immune-regulatory cytokines and cytokine-induced stimulation of indoleamine-2,3-dioxygenase (IDO). There is also some evidence that anti-inflammatory drugs may have a clinical efficacy in MDD.The aim of this study is to examine the clinical effects of an eight-week combinatorial treatment of ketoprofen (a nonsteroidal anti-inflammatory drug) combined or not with sertraline, on serum levels of IDO, interferon (IFN)-&gamma;, interleukin (IL)-4 and transforming growth factor (TGF)-&beta;1 in association with changes in the Beck-Depression Inventory-II (BDI-II). The study included 140 MDD patients and 40 normal controls. The pre-treatment serum levels of IDO, IFN-&gamma;, TGF-&beta;1 and IL-4 were significantly higher in MDD patients compared with the control group. Treatment with sertraline with or without ketoprofen significantly reduced the increased baseline production of all 4 biomarkers to levels which were similar as those of normal controls. Ketoprofen add-on had a significantly greater effect on IDO and BDI-II as compared with placebo. The reductions in IDO, IL-4 and TGF-&beta;1 during treatment were significantly associated with those in the BDI-II.In conclusion, the clinical efficacy of both sertraline + ketoprofen may be ascribed at least in part to attenuated IDO levels and immune-inflammatory responses in MDD. Moreover, add-on treatment with ketoprofen may augment the efficacy of sertraline by attenuating IDO. However, these treatments may also significantly reduce the more beneficial properties of T helper-2 and T regulatory (Treg) immune subsets. Future research should develop immune treatments that target the immune-inflammatory response in MDD, while enhancing the compensatory immune-regulatory system (CIRS).

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