scholarly journals Tobacco smoke exposure and sleep: estimating the association of urinary cotinine with sleep quality

2020 ◽  
Vol 40 (3) ◽  
pp. 70-80 ◽  
Author(s):  
Moe Zandy ◽  
Vicky Chang ◽  
Deepa P. Rao ◽  
Minh T. Do
Keyword(s):  
Logistic Regression ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Tobacco Smoke ◽  
Sleep Problems ◽  
Biological Marker ◽  
Quality Measures ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Urinary Cotinine

Introduction A majority of studies on tobacco smoke exposure and sleep quality have relied on self-reported smoking, resulting in potential exposure misclassification and biases related to self-report. The objective of this study was to investigate associations between urinary cotinine, a biological marker of tobacco smoke exposure, and sleep quality measures, including sleep duration, sleep continuity or efficiency, sleep satisfaction and alertness during normal waking hours. Methods Using data on a national sample of 10 806 adults (aged 18–79 years) from the Canadian Health Measures Survey (2007–2013), we performed binary logistic regression analyses to estimate associations between urinary cotinine concentrations and sleep quality measures, while controlling for potential confounders. Additionally, we performed ordinal logistic regression to assess the association between urinary cotinine concentrations and increased number of sleep problems. Results Overall, 28.7% of adult Canadian survey respondents had urinary cotinine concentrations above the limit of detection (LOD), and the prevalence of each sleep problem ranged from 5.5% to 35.6%. Elevated urinary cotinine concentrations (quartile 4 vs. $lt;LOD) were associated with significantly higher odds of short or long sleep duration (OR = 1.41; 95% CI: 1.02–1.95; p-trend = .021), trouble falling or staying asleep (OR = 1.71; 95% CI: 1.28–2.27; p-trend = .003), sleep dissatisfaction (OR = 1.87; 95% CI: 1.21–2.89; p-trend = .011), and increased number of sleep problems (OR = 1.64; 95% CI: 1.19–2.26; p-trend = .001). Stronger associations were observed among females compared to males. Conclusion Using a biological marker of tobacco smoke exposure, our study contributes to the body of literature of toxic environmental exposures on sleep quality by supporting an association between tobacco smoke exposure and poorer sleep quality. To address the limitations of a cross-sectional study design and to better assess the temporality of tobacco smoke exposure and sleep quality, longitudinal studies are recommended.

Assessment of tobacco smoke exposure in Hong Kong preschool children: questionnaire or urinary cotinine?

2012 ◽  
Vol 13 ◽  
pp. S67-S68
Author(s):  
T.F. Leung ◽  
I.H.S. Chan ◽  
T.C. Liu ◽  
W.C. Chan ◽  
H.Y. Sy ◽  
...  
Keyword(s):  
Hong Kong ◽  
Preschool Children ◽  
Tobacco Smoke ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Urinary Cotinine

scholarly journals URINARY COTININE AS A MEASURE OF TOBACCO SMOKE EXPOSURE IN UTERO AND INFANCY

1984 ◽  
Vol 18 ◽  
pp. 229A-229A
Author(s):  
R Etzel ◽  
R Greenberg ◽  
N Haley ◽  
F Loda
Keyword(s):  
Tobacco Smoke ◽  
In Utero ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Urinary Cotinine

scholarly journals Assessing secondhand and thirdhand tobacco smoke exposure in Canadian infants using questionnaires, biomarkers, and machine learning

2021 ◽  
Author(s):  
Jaclyn Parks ◽  
Kathleen E. McLean ◽  
Lawrence McCandless ◽  
Russell J. de Souza ◽  
Jeffrey R. Brook ◽  
...  
Keyword(s):  
Machine Learning ◽  
Tobacco Smoke ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Linear Regression Models ◽  
Thirdhand Smoke ◽  
Urinary Cotinine ◽  
Smoking Exposure ◽  
Shs Exposure ◽  
Technological Improvements

Abstract Background As smoking prevalence has decreased in Canada, particularly during pregnancy and around children, and technological improvements have lowered detection limits, the use of traditional tobacco smoke biomarkers in infant populations requires re-evaluation. Objective We evaluated concentrations of urinary nicotine biomarkers, cotinine and trans-3’-hydroxycotinine (3HC), and questionnaire responses. We used machine learning and prediction modeling to understand sources of tobacco smoke exposure for infants from the CHILD Cohort Study. Methods Multivariable linear regression models, chosen through a combination of conceptual and data-driven strategies including random forest regression, assessed the ability of questionnaires to predict variation in urinary cotinine and 3HC concentrations of 2017 3-month-old infants. Results Although only 2% of mothers reported smoking prior to and throughout their pregnancy, cotinine and 3HC were detected in 76 and 89% of the infants’ urine (n = 2017). Questionnaire-based models explained 31 and 41% of the variance in cotinine and 3HC levels, respectively. Observed concentrations suggest 0.25 and 0.50 ng/mL as cut-points in cotinine and 3HC to characterize SHS exposure. This cut-point suggests that 23.5% of infants had moderate or regular smoke exposure. Significance Though most people make efforts to reduce exposure to their infants, parents do not appear to consider the pervasiveness and persistence of secondhand and thirdhand smoke. More than half of the variation in urinary cotinine and 3HC in infants could not be predicted with modeling. The pervasiveness of thirdhand smoke, the potential for dermal and oral routes of nicotine exposure, along with changes in public perceptions of smoking exposure and risk warrant further exploration.

scholarly journals Limited Value of Urinary Cotinine to Creatinine Ratio as an Indicator for Tobacco Smoke Exposure

1992 ◽  
Vol 2 (2) ◽  
pp. 91-95
Author(s):  
Masahiro Kihara ◽  
Masako Kihara ◽  
Naoyuki Okamoto ◽  
Eigo Higashi ◽  
Shigeru Matsukura ◽  
...  
Keyword(s):  
Tobacco Smoke ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Creatinine Ratio ◽  
Urinary Cotinine

A monoclonal antibody-based enzyme-linked immunosorbent assay for human urinary cotinine to monitor tobacco smoke exposure

2011 ◽  
Vol 3 (9) ◽  
pp. 1995 ◽  
Author(s):  
Norihiro Kobayashi ◽  
Erika Banzono ◽  
Yuko Shimoda ◽  
Hiroyuki Oyama ◽  
Toshiomi Kunihiro ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Immunosorbent Assay ◽  
Tobacco Smoke ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Enzyme Linked Immunosorbent Assay ◽  
Urinary Cotinine

A Validated Method for Urinary Cotinine Quantification Used to Classify Active and Environmental Tobacco Smoke Exposure

2013 ◽  
Vol 9 (3) ◽  
pp. 447-456 ◽  
Author(s):  
Silvia Fustinoni ◽  
Laura Campo ◽  
Elisa Polledri ◽  
Rosa Mercadante ◽  
Laura Erspamer ◽  
...  
Keyword(s):  
Environmental Tobacco Smoke ◽  
Tobacco Smoke ◽  
Environmental Tobacco Smoke Exposure ◽  
Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Urinary Cotinine
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