scholarly journals Evaluation on Clinical Effect of Platelet Rich Plasma in Treatment of Non-infective Bone Ununion

2018 ◽  
Keyword(s):  
Clinical Effect ◽  
Platelet Rich Plasma

scholarly journals The clinical effect of platelet-rich plasma injections on symptomatic meniscal tears of the knee

2021 ◽  
Vol 26 (3) ◽  
pp. 367-370
Author(s):  
Veysel Delen ◽  
Levent Ediz ◽  
Mahmut Alpaycı
Keyword(s):  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
Meniscal Tears

Perineural Platelet-Rich Plasma for Diabetic Neuropathic Pain, Could It Make a Difference?

Pain Medicine ◽  
2019 ◽  
Vol 21 (4) ◽  
pp. 757-765
Author(s):  
Manal Hassanien ◽  
Abdelraheem Elawamy ◽  
Emad Zarief Kamel ◽  
Walaa A Khalifa ◽  
Ghada Mohamed Abolfadl ◽  
...  
Keyword(s):  
Medical Treatment ◽  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
University Hospital ◽  
Pain Clinic ◽  
Diabetic Neuropathic Pain ◽  
Group I ◽  
Scale Scores ◽  
Peripheral Nerve Function ◽  
Group Ii

AbstractObjectiveTo evaluate the clinical effect of perineural platelet-rich plasma (PRP) injection for pain and numbness alleviation in diabetic peripheral neuropathy (DPN).Study DesignA randomized prospective clinical trial.SettingPain clinic and Rheumatology and Rehabilitation Departments, Assiut University Hospital.MethodsSixty adult patients with type II DM accompanied by DPN of at least six months’ duration were assessed by modified Toronto Clinical Neuropathy Score (mTCNS) and randomly allocated into two groups. Group I underwent ultrasound-guided perineural PRP injection and medical treatment, and Group II received medical treatment only. Patients were followed up at months 1, 3, and 6 with regard to pain and numbness visual analog scale (VAS) and mTCNS scores.ResultsSignificant improvement was recorded in pain and numbness VAS scale scores in group I vs group II (P ≤ 0.001 during the whole study period for both parameters); at the same time, mTCNS improved in group I in comparison with group II with P = 0.01, 0.001, and <0.001 at months 1, 3, and 6, respectively.ConclusionsPerineural PRP injection is an effective therapy for alleviation of diabetic neuropathy pain and numbness and enhancement of peripheral nerve function.

Effect of Platelet-Rich Plasma on the Outcome of Early Loaded Dental Implants: A 3-Year Follow-up Study

2013 ◽  
Vol 39 (S1) ◽  
pp. 256-263 ◽  
Author(s):  
Gulfem Ergun ◽  
Ferhan Egilmez ◽  
Isil Cekic-Nagas ◽  
İnci Rana Karaca ◽  
Suleyman Bozkaya
Keyword(s):  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
Resonance Frequency Analysis ◽  
Implant Stability ◽  
Median Line ◽  
Implant Stability Quotient ◽  
Metal Ceramic ◽  
Ceramic Crowns ◽  
Prosthetic Complications

This study evaluated the effect of local application of platelet-rich plasma (PRP) on the outcome of early loaded implants. Two implants were placed in the posterior region or bilaterally symmetric to the median line of the maxilla. Then, PRP was either applied or not applied to the implant sockets. Outcome measures were prosthesis and implant success as well as biological and prosthetic complications. Stability of individual implants was assessed manually and with a resonance frequency analysis device. The implant stability quotient (ISQ) was recorded on the operation day, on postoperative day 4, and at postoperative week 1. At the end of the first postoperative week, implants with ISQ values >60 were early loaded on day 7 with metal-ceramic crowns. Measurements were repeated at postoperative weeks 2, 3, and 4 and at postoperative months 6, 12, 24, and 36. One of the 64 implants was dropped out after 3 months of loading. No prosthesis failed. There were no prosthetic complications. Statistical analysis revealed significant differences between ISQ values of PRP and non-PRP implants on the operation day. Moreover, no statistically significant differences were found between ISQ values of PRP and non-PRP implants in the follow-up periods (P > .05). No appreciable clinical effect was observed when using PRP in the maxilla.

scholarly journals Use of Autologous Leucocyte- and Platelet-Rich Plasma (L-PRP) in the Treatment of Aural Hematoma in Dogs

2021 ◽  
Vol 8 (9) ◽  
pp. 172
Author(s):  
Roberta Perego ◽  
Eva Spada ◽  
Elena Moneta ◽  
Luciana Baggiani ◽  
Daniela Proverbio
Keyword(s):  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
Healing Process ◽  
Short Term ◽  
Clinical Resolution ◽  
The Mean ◽  
Clinical Healing ◽  
Mean Time

Leukocyte- and platelet-rich plasma (L-PRP) can accelerate the healing process by providing increased concentrations of platelet-derived growth factors. The objective of this study was to evaluate the clinical effect of L-PRP in the treatment of canine aural hematomas associated with otitis externa. Twenty mL of citrated whole blood was collected from each of the 17 dogs included and autologous L-PRP was produced. The aural hematoma was drained and 0.5–1 mL of L-PRP was injected. The dogs were examined weekly until 7 days after complete clinical healing. A final clinical follow-up was performed 6 weeks after the first treatment with L-PRP. If there was recurrence of the aural hematoma at the first follow-up, the treatment was repeated. In total, 2/17 cases were lost after the first follow-up. In 5/17 dogs, a short-term recurrence occurred. In 12/15 cases, complete clinical resolution was achieved with a single L-PRP application (Group A1) and in 3/15 with two treatments (Group A2). The mean time to complete clinical resolution was 16 ± 8.7 days (A1) and 23.3 ± 4 days (A2), respectively. No side effects were reported. The in situ administration of autologous L-PRP resulted in a complete resolution of the aural hematoma in all dogs that completed the clinical trial.

Role of Red Blood Cells in the Early Stages of Platelet Activation by Collagen

1986 ◽  
Vol 56 (03) ◽  
pp. 376-381 ◽  
Author(s):  
M Teresa Santos ◽  
Juana Vallés ◽  
Justo Aznar ◽  
J Luis Pérez-Requejo
Keyword(s):  
Red Blood Cells ◽  
Platelet Activation ◽  
Blood Cells ◽  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
Lower Number ◽  
Antithrombotic Drug ◽  
A Cell

SummaryRed blood cells (RBC) increase the proaggregatory capacity of a cell-free supernatant obtained by stimulating platelet-rich plasma (PRP) samples with collagen (1 μg/ml) as measured by the BASIC wave; this effect increases with the number of RBC and is proportionally greater with a lower number of platelets or when lower collagen concentrations are used.Aspirin (ASA) modifies the RBC behaviour in relation to their platelet-collagen interaction. This is demonstrated by the fact that when PRP and RBC obtained from the same subjects before and two hours after the ingestion of ASA (0.5 g) were mixed, it was found that non-AS A-RBC stimulate ASA-PRP, probably through a platelet cyclooxygenase independent pathway; ASA-RBC, however, stimulate non-ASA-PRP, but not ASA-PRP, which suggests that they may need an active platelet cyclooxygenase system for their action. This effect of ASA on RBC is not transient and was also observable 48 h after ASA ingestion. In addition, it was found that ASA-RBC greatly increase the activation of a mixture containing a small proportion of non-ASA-PRP in ASA-PRP, a situation that is expected to be encountered “in vivo” after ASA treatment. This effect of ASA-RBC on platelet activation may help to explain the sometimes contradictory clinical effect of aspirin as an antithrombotic drug.

scholarly journals Clinical Analysis on the Treatment of Kaschin-Beck Disease of the End-Stage Ankle by Tibiotalocalcaneal Arthrodesis Using Lateral Approach With Platelet-Rich Plasma

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0050
Author(s):  
Li Yi ◽  
Liang Xiaojun ◽  
Zhao Hong-Mou
Keyword(s):  
Internal Fixation ◽  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
Fusion Rate ◽  
Lateral Approach ◽  
Distal Fibula ◽  
Tibiotalocalcaneal Arthrodesis ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Beck Disease

Category: Ankle Arthritis; Ankle Introduction/Purpose: Objective To study the effectiveness of treated Kaschin-Beck Disease of the ankle by tibiotalocalcaneal arthrodesis using lateral approach with autologous platelet-rich plasma. Methods: Retrospective analysis was conducted on the clinical effect of our department on the treatment of 23 patients (25 ankle joints) with severe Kaschin-Beck Disease from May 2014 to May 2016. All patients were treated with tibiotalocalcaneal arthrodesis by using lateral approach of fibula osteotomy with distal fibula cancellous bone combined with autologous platelet rich plasma for bone grafting and internal fixation with full thread cannulated screws or auxiliary lateral plate. Surgical time, blood loss, joint fusion time, delayed wound healing, infection, nonunion of osteotomy surface, chronic pain and other complications were recorded. VAS score and AOFAS ankle and hind foot score were compared before and at the last follow-up. Results: The mean healing time was 14.7 weeks. Postoperative wound healing was delayed in 3 patients. One patient developed superficial infection 1 week after surgery. Bone graft absorption, nonunion of osteotomy surface and loosening of internal fixation were observed in 2 patients. The bone healed at 13 weeks after surgery. 22patients were followed up for an average of 15.7 months. The postoperative AOFAS score was 76 points, and the postoperative VAS score was 2 points with statistically significant differences from the preoperative AOFAS (t=19.13, P<0.01) and VAS (t=17.27, P<0.01). In 21 cases, tibial calcaneal joint fusion was performed in the first stage, and the fusion rate was 87.5%.21 patients received the first stage of bone fusion after surgery, and the fusion rate was 87.5%. Conclusion: Ankle joint and subtalar joint can be well exposed through the lateral approach of fibular osteotomy. The distal fibula autograft with sufficient cancellous bone mass and the combination of autologous platelet rich plasma graft can promote bone healing, and the reliable internal fixation can help achieve satisfactory clinical effect of tibiotalocalcaneal arthrodesis.

scholarly journals Role of Platelet-Rich Plasma (PRP) in Chronic Tendinopathy

2012 ◽  
Vol 23 (1) ◽  
pp. 32-35
Author(s):  
Manoj Sivan ◽  
James Brown
Keyword(s):  
Growth Factors ◽  
Tissue Repair ◽  
Clinical Effect ◽  
Platelet Rich Plasma ◽  
Single Case ◽  
Repair Process ◽  
Future Research ◽  
Sedentary Population ◽  
Randomised Controlled

Abstract Platelet-rich plasma (PRP) is increasingly being used in the treatment of chronic tendinopathy in both sporting and sedentary population. It is rich source of various growth factors and is believed to stimulate and enhance the tissue repair process in tendinopathy. The current literature has six clinical studies (excluding single case studies) which have investigated the effect of PRP in tendinopathy of various tendons. The evidence so far is inconclusive in demonstrating the superiority of PRP over placebo injection or eccentric loading exercises. Future research should focus on conducting randomised controlled studies to establish the clinical effect and support or refute the current widespread use of PRP in chronic tendinopathy.

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