Impact of canonical β-catenin/wnt signaling in normal and impaired by endocrine disruptor dichlordiphenyltrichloroethane postnatal development of the adrenal medulla

2019 ◽  
Vol XIV (2) ◽  
Author(s):  
D.A. Tsomartova ◽  
N.V. Yaglova ◽  
S.V. Nazimova ◽  
S.S. Obernikhin ◽  
V.V. Yaglov
Keyword(s):  
Wnt Signaling ◽  
Postnatal Development ◽  
Adrenal Medulla ◽  
Endocrine Disruptor

Changes in Histophysiology of the Adrenal Medulla in Rats after Prenatal and Postnatal Exposure to Endocrine Disruptor DDT

2020 ◽  
Vol 169 (3) ◽  
pp. 398-400
Author(s):  
N. V. Yaglova ◽  
E. P. Timokhina ◽  
V. V. Yaglov ◽  
S. S. Obernikhin ◽  
S. V. Nazimova ◽  
...  
Keyword(s):  
Adrenal Medulla ◽  
Endocrine Disruptor ◽  
Postnatal Exposure

scholarly journals Asthma Pregnancy Alters Postnatal Development of Chromaffin Cells in the Rat Adrenal Medulla

PLoS ONE ◽  
2011 ◽  
Vol 6 (5) ◽  
pp. e20337 ◽  
Author(s):  
Xiu-Ming Wu ◽  
Cheng-Ping Hu ◽  
Xiao-Zhao Li ◽  
Ye-Qiang Zou ◽  
Jun-Tao Zou ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Adrenal Medulla ◽  
Chromaffin Cells

scholarly journals MORPHOLOGICAL CHANGES OF THE RETICULAR ZONE OF THE CORTEX OF ADRENAL GLANDS AND OF THE SECRETORY ACTIVITY OF ITS CORTICOSTEROCYTES IN THE PUBERTAL PERIOD IN RATS DEVELOPING AT THE INFLUENCE OF THE ENDOCRINAL DISRUPTER DICHLORODIPHENYLTRICHLOROETHANE

2018 ◽  
Vol 26 (2) ◽  
pp. 22-25
Author(s):  
D. A. Tsomartova ◽  
N. V. Yaglova ◽  
V. V. Yaglov ◽  
S. S. Obernikhin ◽  
S. V. Nazimova ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Postnatal Development ◽  
Sex Steroids ◽  
Endocrine Disruptor ◽  
Morphological Changes ◽  
Secretory Activity ◽  
Progressive Increase ◽  
Daily Consumption ◽  
Zona Reticularis ◽  
Structural Support

Affection of developing organism by endocrine disruptors is an actively studied topic of scientific research in medicine, caused by a progressive increase in the number of diseases and disorders in the development of the reproductive and endocrine systems. Dichlorodiphenyltrichloroethane (DDT) is the most wide-spread endocrine disruptor. Low-dose exposure to DDT disrupts production of sex steroids by poorly known mechanisms. The research was focused on assessment of morphology of adrenal zona reticularis and fine structure of reticularis endocrine cells and changes in their secretory machinery in rats exposed to low doses of DDT during prenatal and postnatal development. The experimental group consisted of the male offspring of dams, who daily consumed solution of o, p-DDT at a concentration of 20 µg/l, from mating until the end of the suckling period in offspring, which then consumed a similar solution of DDT. Daily consumption of DDT by the offspring was 2,90±0,12 µg/kg body weight. These doses corresponds to levels of exposure of humans to DDT with food products taking to account the differences in metabolism of DDT in rats and humans. The control and experimental rats were sacrificed on the 42nd day of postnatal development (pubertal period). Light microscopy of adrenal sections found hypoplasia of zona reticularis in rats after developmental exposure to endocrine disruptor. Electron microscopy revealed prevalence of cells with low lipid content in cytoplasm, less developed endoplasmatic reticulum and Golgi complex and signs of lowered functional activity of mitochondria indicated decreased steroidogenic activity of zona reticularis. These findings explain previously found impaired production of sex steroids in DDT-exposed rats. Electron microscopy also found that disruption of steroid secretion in reticularis cells by DDT led to compensatory enlargement of cells and increase in number of mitochondria per m2 of cytoplasm indicating development of structural support for long-term enhancement of steroidogenic activity.

Opossum adrenal medulla: I. Postnatal development and normal anatomy

1987 ◽  
Vol 179 (3) ◽  
pp. 211-219 ◽  
Author(s):  
Stephen W. Carmichael ◽  
Daniel B. Spagnoli ◽  
Richard G. Frederickson ◽  
William J. Krause ◽  
James L. Culberson
Keyword(s):  
Postnatal Development ◽  
Adrenal Medulla ◽  
Normal Anatomy

Maternal Perinatal Undernutrition Alters Postnatal Development of Chromaffin Cells in the Male Rat Adrenal Medulla

2009 ◽  
Vol 90 (1) ◽  
pp. 54-66 ◽  
Author(s):  
Olivier Molendi-Coste ◽  
Christine Laborie ◽  
Maria Cristina Scarpa ◽  
Valérie Montel ◽  
Didier Vieau ◽  
...  
Keyword(s):  
Postnatal Development ◽  
Adrenal Medulla ◽  
Chromaffin Cells ◽  
Male Rat
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