Study of biocompatibility of the material based on small intestinal submucosa in tests in vitro and in vivo

2019 ◽  
Vol XIV (2) ◽  
Author(s):  
А.А. Dolgalev ◽  
А.А. Venediktov ◽  
D.V. Bobryshev ◽  
А.D. Kruchinina ◽  
А.А. Chagarov ◽  
...  
Keyword(s):  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

In vivo release of bovine serum albumin from an injectable small intestinal submucosa gel

2011 ◽  
Vol 420 (2) ◽  
pp. 266-273 ◽  
Author(s):  
Kkot Nim Kang ◽  
Da Yeon Kim ◽  
So Mi Yoon ◽  
Jin Seon Kwon ◽  
Hyo Won Seo ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Small Intestinal Submucosa ◽  
In Vivo Release ◽  
Small Intestinal ◽  
Intestinal Submucosa

scholarly journals Effect of Multilaminate Small Intestinal Submucosa as a Barrier Membrane on Bone Formation in a Rabbit Mandible Defect Model

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Weiyi Wu ◽  
Bowen Li ◽  
Yuhua Liu ◽  
Xinzhi Wang ◽  
Lin Tang
Keyword(s):  
Bone Regeneration ◽  
Porous Scaffold ◽  
Small Intestinal Submucosa ◽  
Control Group ◽  
Collagen Membrane ◽  
Defect Model ◽  
Barrier Membrane ◽  
Small Intestinal ◽  
Intestinal Submucosa

A barrier membrane (BM) is essential for guided bone regeneration (GBR) procedures. Absorbable BMs based on collagen have been widely applied clinically due to their excellent biocompatibility. The extracellular matrix (ECM) provides certain advantages that can compensate for the rapid degradation and insufficient mechanical strength of pure collagen membrane due to the porous scaffold structure. Recently, small intestinal submucosa (SIS), one of the most widely used ECM materials, has drawn much attention in bone tissue engineering. In this study, we adopted multilaminate SIS (mSIS) as a BM and evaluated its in vivo and in vitro properties. mSIS exhibited a multilaminate structure with a smooth upper surface and a significantly coarser bottom layer according to microscopic observation. Tensile strength was 13.10 ± 2.56 MPa. In in vivo experiments, we selected a rabbit mandibular defect model and subcutaneous implantation to compare osteogenesis and biodegradation properties with one of the most commonly used commercial collagen membranes. mSIS was retained for up to 3 months and demonstrated longer biodegradation time than commercial collagen membrane. Quantification of bone regeneration revealed significant differences in each group. Micro-computed tomography (micro-CT) revealed that the quantity and maturity of bones in the mSIS group were significantly higher than those in the blank control group (P < 0.05) and were similar to those in a commercial collagen membrane group (P > 0.05) at 4 and 12 weeks after surgery. Hematoxylin and eosin staining revealed large amounts of mature lamellar bone at 12 weeks in mSIS and commercial collagen membrane groups. Therefore, we conclude that mSIS has potential as a future biocompatible BM in GBR procedures.

IN VIVO TISSUE ENGINEERING OF THE COMMON BILE DUCT USING SMALL INTESTINAL SUBMUCOSA IN A CANINE MODEL

ASAIO Journal ◽  
2002 ◽  
Vol 48 (2) ◽  
pp. 197
Author(s):  
Dai Kimura ◽  
Tatsuo Nakamura ◽  
Kenji Kaino ◽  
Yoshio Hori ◽  
Masaki Nio ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bile Duct ◽  
Common Bile Duct ◽  
Canine Model ◽  
Small Intestinal Submucosa ◽  
In Vivo Tissue Engineering ◽  
The Common ◽  
Small Intestinal ◽  
Intestinal Submucosa

In Vivo Motility Evaluation of the Grafted Gastric Wall with Small Intestinal Submucosa

2010 ◽  
Vol 16 (5) ◽  
pp. 1761-1768 ◽  
Author(s):  
Taku Nishimura ◽  
Tomio Ueno ◽  
Hiroki Nakatsu ◽  
Atsunori Oga ◽  
Sei Kobayashi ◽  
...  
Keyword(s):  
Gastric Wall ◽  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

Characterization of Small Intestinal Submucosa Regenerated Canine Detrusor: Assessment of Reinnervation, in Vitro Compliance and Contractility

1996 ◽  
Vol 156 (2S) ◽  
pp. 599-607 ◽  
Author(s):  
Bradley P. Kropp ◽  
Barry D. Sawyer ◽  
Harlon E. Shannon ◽  
Marian K. Rippy ◽  
Stephen F. Badylak ◽  
...  
Keyword(s):  
Small Intestinal Submucosa ◽  
Small Intestinal ◽  
Intestinal Submucosa

Small Intestinal Submucosa: A Tissue-Derived Extracellular Matrix That Promotes Tissue-Specific Growth and Differentiation of Cells in Vitro

1998 ◽  
Vol 4 (2) ◽  
pp. 157-174 ◽  
Author(s):  
Sherry L. Voytik-Harbin ◽  
Andrew O. Brightman ◽  
Beverly Z. Waisner ◽  
J. Paul Robinson ◽  
Carlton H. Lamar
Keyword(s):  
Extracellular Matrix ◽  
Specific Growth ◽  
Small Intestinal Submucosa ◽  
Tissue Specific ◽  
Small Intestinal ◽  
Intestinal Submucosa
Sign in / Sign up

Export Citation Format

Share Document