scholarly journals Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology

2010 ◽  
Vol 177 (6) ◽  
pp. 3037-3050 ◽  
Author(s):  
Karen A. Lewis ◽  
Yang Su ◽  
Olina Jou ◽  
Caroline Ritchie ◽  
Chan Foong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Pathology ◽  
Abnormal Neurites

Linkage of Parkinsonism and Alzheimer's disease with Lewy body pathology to chromosome 12

2002 ◽  
Vol 52 (4) ◽  
pp. 524-524
Author(s):  
William K. Scott ◽  
Jeffery M. Vance ◽  
Jonathan L. Haines ◽  
Margaret A. Pericak-Vance
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Chromosome 12 ◽  
Lewy Body Pathology

Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease

2003 ◽  
Vol 105 (5) ◽  
pp. 484-488 ◽  
Author(s):  
Yuri Trembath ◽  
Carolyn Rosenberg ◽  
John F. Ervin ◽  
Donald E. Schmechel ◽  
Perry Gaskell ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Familial Alzheimer’S Disease ◽  
Lewy Body Pathology ◽  
Familial Alzheimer's Disease

scholarly journals Abnormal Sleep Behaviours Across the Spectrum of Alzheimer’s Disease Severity: Influence of APOE Genotypes and Lewy Bodies

2019 ◽  
Vol 16 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Ka Yi G. Koo ◽  
Tom A. Schweizer ◽  
Corinne E. Fischer ◽  
David G. Munoz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Sleep Disturbances ◽  
Braak Stage ◽  
Sleep Patterns ◽  
Apoe Ε4 ◽  
Lewy Body Pathology ◽  
The Relationship ◽  
Abnormal Sleep

Background: The Apolipoprotein (APOE) ε4 allele is a well-known risk factor for Alzheimer’s Disease (AD), and sleep disturbances are commonly associated with AD. However, few studies have investigated the relationship between APOE ε4 and abnormal sleep patterns (N+) in AD. Objective: To examine the relationship between APOE genotype, Lewy body pathology, and abnormal sleep patterns in a large group of subjects with known AD load evaluated upon autopsy. Method: Data from 2,368 cases obtained from the National Alzheimer’s Coordinating Centre database were categorized as follows: Braak Stage V/VI and CERAD frequent neuritic plaques as high load AD, Braak Stage III/IV and moderate CERAD as intermediate load AD, and Braak Stage 0/I/II and infrequent CERAD as no to low load AD. Cases discrepant between the two measures were discarded. Results: Disrupted sleep was more frequent in males (42.4%) compared to females (35.1%), and in carriers (42.3%) as opposed to non-carriers (36.5%) of ε4. Amongst female subjects with high AD load and Lewy body pathology, homozygous (ε4/ε4) carriers experienced disrupted sleep more often compared with heterozygous (ε4/x) or non-carriers of ε4. Such recessive, gender-specific, and Lewy body association is reminiscent of the ε4 effect on psychosis in AD. However, such association was lost after adjusting for covariates. In subjects with no to low AD pathology, female ε4 carriers had significantly more nighttime disturbances than non-carriers; this effect is independent of the presence of Lewy body pathology. Conclusion: The influence of APOE ε4 on sleep disturbances is dependent on gender and severity of AD load.

Predicting Lewy Body Pathology in a Community-Based Sample With Clinical Diagnosis of Alzheimer’s Disease

2006 ◽  
Vol 19 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Debby Tsuang ◽  
Kate Simpson ◽  
Eric B. Larson ◽  
Elaine Peskind ◽  
Walter Kukull ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Diagnosis ◽  
Lewy Body ◽  
Community Based ◽  
Lewy Body Pathology

scholarly journals The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease

2014 ◽  
Vol 23 (18) ◽  
pp. 4814-4821 ◽  
Author(s):  
C. Linnertz ◽  
M. W. Lutz ◽  
J. F. Ervin ◽  
J. Allen ◽  
N. R. Miller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Pathology ◽  
Genetic Contributions

scholarly journals Lewy body pathology in Alzheimer's disease: A clinicopathological prospective study

2018 ◽  
Vol 139 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Rodolfo Savica ◽  
Thomas G. Beach ◽  
Joseph G. Hentz ◽  
Marwan N. Sabbagh ◽  
Geidy E. Serrano ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prospective Study ◽  
Lewy Body ◽  
Lewy Body Pathology
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