scholarly journals Associations between Comorbid TDP-43, Lewy Body Pathology, and Neuropsychiatric Symptoms in Alzheimer’s Disease

2019 ◽  
Vol 69 (4) ◽  
pp. 953-961 ◽  
Author(s):  
Ece Bayram ◽  
Guogen Shan ◽  
Jeffrey L. Cummings
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Neuropsychiatric Symptoms ◽  
Lewy Body Pathology

Linkage of Parkinsonism and Alzheimer's disease with Lewy body pathology to chromosome 12

2002 ◽  
Vol 52 (4) ◽  
pp. 524-524
Author(s):  
William K. Scott ◽  
Jeffery M. Vance ◽  
Jonathan L. Haines ◽  
Margaret A. Pericak-Vance
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Chromosome 12 ◽  
Lewy Body Pathology

Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease

2003 ◽  
Vol 105 (5) ◽  
pp. 484-488 ◽  
Author(s):  
Yuri Trembath ◽  
Carolyn Rosenberg ◽  
John F. Ervin ◽  
Donald E. Schmechel ◽  
Perry Gaskell ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Familial Alzheimer’S Disease ◽  
Lewy Body Pathology ◽  
Familial Alzheimer's Disease

scholarly journals Neuropsychiatric symptoms correlated with functional trajectories among people living with Alzheimer’s disease dementia and Lewy body dementia

2020 ◽  
Vol 16 (S8) ◽  
Author(s):  
Miguel German Borda ◽  
Dag Aarsland ◽  
Ketil Oppedal ◽  
Lasse Melvær Giil ◽  
Audun Osland Vik‐Mo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Neuropsychiatric Symptoms ◽  
Lewy Body Dementia ◽  
Alzheimer’S Disease Dementia

scholarly journals Abnormal Sleep Behaviours Across the Spectrum of Alzheimer’s Disease Severity: Influence of APOE Genotypes and Lewy Bodies

2019 ◽  
Vol 16 (3) ◽  
pp. 243-250 ◽  
Author(s):  
Ka Yi G. Koo ◽  
Tom A. Schweizer ◽  
Corinne E. Fischer ◽  
David G. Munoz
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Sleep Disturbances ◽  
Braak Stage ◽  
Sleep Patterns ◽  
Apoe Ε4 ◽  
Lewy Body Pathology ◽  
The Relationship ◽  
Abnormal Sleep

Background: The Apolipoprotein (APOE) ε4 allele is a well-known risk factor for Alzheimer’s Disease (AD), and sleep disturbances are commonly associated with AD. However, few studies have investigated the relationship between APOE ε4 and abnormal sleep patterns (N+) in AD. Objective: To examine the relationship between APOE genotype, Lewy body pathology, and abnormal sleep patterns in a large group of subjects with known AD load evaluated upon autopsy. Method: Data from 2,368 cases obtained from the National Alzheimer’s Coordinating Centre database were categorized as follows: Braak Stage V/VI and CERAD frequent neuritic plaques as high load AD, Braak Stage III/IV and moderate CERAD as intermediate load AD, and Braak Stage 0/I/II and infrequent CERAD as no to low load AD. Cases discrepant between the two measures were discarded. Results: Disrupted sleep was more frequent in males (42.4%) compared to females (35.1%), and in carriers (42.3%) as opposed to non-carriers (36.5%) of ε4. Amongst female subjects with high AD load and Lewy body pathology, homozygous (ε4/ε4) carriers experienced disrupted sleep more often compared with heterozygous (ε4/x) or non-carriers of ε4. Such recessive, gender-specific, and Lewy body association is reminiscent of the ε4 effect on psychosis in AD. However, such association was lost after adjusting for covariates. In subjects with no to low AD pathology, female ε4 carriers had significantly more nighttime disturbances than non-carriers; this effect is independent of the presence of Lewy body pathology. Conclusion: The influence of APOE ε4 on sleep disturbances is dependent on gender and severity of AD load.

Predicting Lewy Body Pathology in a Community-Based Sample With Clinical Diagnosis of Alzheimer’s Disease

2006 ◽  
Vol 19 (4) ◽  
pp. 195-201 ◽  
Author(s):  
Debby Tsuang ◽  
Kate Simpson ◽  
Eric B. Larson ◽  
Elaine Peskind ◽  
Walter Kukull ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Clinical Diagnosis ◽  
Lewy Body ◽  
Community Based ◽  
Lewy Body Pathology

A-1 Neuropsychiatric Symptoms over Time in Autopsy-Confirmed Alzheimer’s Disease, Lewy Body Disease, and Mixed Pathology

2021 ◽  
Vol 36 (6) ◽  
pp. 1022-1022
Author(s):  
Jeff Schaffert ◽  
Will Goette ◽  
Anne Carlew ◽  
Allison Parker ◽  
Saranya Patel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Neuropsychiatric Symptoms ◽  
Depression Scale ◽  
Lewy Body Disease ◽  
Cognitive Status ◽  
Future Research ◽  
Final Visit ◽  
Over Time

Abstract Objective Neuropsychiatric symptoms (NPS) are common in neurodegenerative disease, but longitudinal studies using large autopsy-confirmed samples are lacking. Our primary aim was to investigate progression of NPS over time in autopsy-confirmed Alzheimer’s disease (ad), Lewy body disease (LBD), and mixed (ad+LBD) cohorts. Methods Data on individuals (age > =50) with autopsy-confirmed ad (N = 1568), ad+LBD (N = 349), and LBD (N = 142) was obtained from the National Alzheimer’s Coordinating Center (Mean visits = 2.61). Neuropsychiatric Inventory Questionnaire (NPI-Q) and 15-item Geriatric Depression Scale (GDS) scores were used to measure NPS. Multilevel zero-inflated binomial regression models were used to assess if NPI-Q and GDS scores differed among ad, ad+LBD, and LBD groups over time. Covariates included: years from baseline to final visit, cognitive status at baseline (i.e., normal, MCI, or dementia), demographic characteristics, MMSE, Functional Activities Questionnaire, and psychotropic treatment of psychiatric conditions. Results Higher NPI-Q and GDS scores were observed at baseline in the LBD group compared to ad (p’s < 0.001). NPI-Q scores increased over time in the LBD group compared to ad+LBD and ad groups (90% CI). GDS scores differed among all groups at baseline (95% CI), with more rapid increase in the LBD group vs. ad and ad+LBD groups. Conclusions Overall, the course of NPS differs among disease pathologies. Those with pure LBD appear to have more severe NPS over time compared to those with ad and ad+LBD. Depressive symptoms increased more in LBD and ad+LBD compared to ad over time. Future research examining clinical outcomes related to NPS burden (care needs, caregiver burden, and life expectancy) is needed.

scholarly journals The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease

2014 ◽  
Vol 23 (18) ◽  
pp. 4814-4821 ◽  
Author(s):  
C. Linnertz ◽  
M. W. Lutz ◽  
J. F. Ervin ◽  
J. Allen ◽  
N. R. Miller ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Pathology ◽  
Genetic Contributions

scholarly journals Lewy body pathology in Alzheimer's disease: A clinicopathological prospective study

2018 ◽  
Vol 139 (1) ◽  
pp. 76-81 ◽  
Author(s):  
Rodolfo Savica ◽  
Thomas G. Beach ◽  
Joseph G. Hentz ◽  
Marwan N. Sabbagh ◽  
Geidy E. Serrano ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Prospective Study ◽  
Lewy Body ◽  
Lewy Body Pathology
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