scholarly journals Stromal Cell-Derived Factor-1 Is Essential for Photoreceptor Cell Protection in Retinal Detachment

2010 ◽  
Vol 177 (5) ◽  
pp. 2268-2277 ◽  
Author(s):  
Hiroki Otsuka ◽  
Noboru Arimura ◽  
Shozo Sonoda ◽  
Makoto Nakamura ◽  
Teruto Hashiguchi ◽  
...  
Keyword(s):  
Retinal Detachment ◽  
Stromal Cell ◽  
Photoreceptor Cell ◽  
Cell Protection ◽  
Stromal Cell Derived Factor

scholarly journals Stromal Cell-Derived Factor 1α (SDF-1α) in Invasive Breast Cancer: Associations with Vasculo-Angiogenic Factors and Prognostic Significance

Cancers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1952
Author(s):  
Elżbieta Zarychta ◽  
Barbara Ruszkowska-Ciastek ◽  
Kornel Bielawski ◽  
Piotr Rhone
Keyword(s):  
Breast Cancer ◽  
Invasive Breast Cancer ◽  
Stromal Cell ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Breast Cancer Patients ◽  
Roc Curve Analysis ◽  
Stromal Cell Derived Factor ◽  
A Prospective Study

(1) Background: Tumour angiogenesis is critical for the progression of neoplasms. A prospective study was designed to examine the utility of stromal cell-derived factor 1α (SDF-1α) and selected vasculo-angiogenic parameters for estimating the probability of disease relapse in 84 primary, operable invasive breast cancer (IBrC) patients (40 (48%) with stage IA and 44 (52%) with stage IIA and IIB). (2) Methods: We explored the prognostic value of the plasma levels of SDF-1α, vascular endothelial growth factor A (VEGF-A), the soluble forms of VEGF receptors type 1 and 2, and the number of circulating endothelial progenitor cells (circulating EPCs) in breast cancer patients. The median follow-up duration was 58 months, with complete follow-up for the first event. (3) Results: According to ROC curve analysis, the optimal cut-off point for SDF-1α (for discriminating between patients at high and low risk of relapse) was 42 pg/mL, providing 57% sensitivity and 75% specificity. Kaplan–Meier curves for disease-free survival (DFS) showed that concentrations of SDF-1α lower than 42 pg/dL together with a VEGFR1 lower than 29.86 pg/mL were significantly associated with shorter DFS in IBrC patients (p = 0.0381). Patients with both SDF-1α lower than 42 pg/dL and a number of circulating EPCs lower than 9.68 cells/µL had significantly shorter DFS (p = 0.0138). (4) Conclusions: Our results imply the clinical usefulness of SDF-1α, sVEGFR1 and the number of circulating EPCs as prognostic markers for breast cancer in clinical settings.

Stromal cell-derived factor-1 may play pivotal role in distraction-stimulated neovascularization of diabetic foot ulcer

2021 ◽  
pp. 110548
Author(s):  
Jiezhuang Fang ◽  
Jiankun Xu ◽  
Yuantao Zhang ◽  
Hongjiang Chen ◽  
Zebin Ma ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Stromal Cell ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Pivotal Role ◽  
Stromal Cell Derived Factor

scholarly journals Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment

2014 ◽  
Vol 5 (5) ◽  
pp. e1269-e1269 ◽  
Author(s):  
H Matsumoto ◽  
Y Murakami ◽  
K Kataoka ◽  
H Lin ◽  
K M Connor ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Detachment ◽  
Photoreceptor Cell
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