scholarly journals Stromal Cell-Derived Factor 1 Gene Polymorphism Is Associated with Susceptibility to Adverse Long-Term Allograft Outcomes in Non-Diabetic Kidney Transplant Recipients

2014 ◽  
Vol 15 (7) ◽  
pp. 12495-12506 ◽  
Author(s):  
Chung-Jieh Wang ◽  
Jen-Pi Tsai ◽  
Shun-Fa Yang ◽  
Jong-Da Lian ◽  
Horng-Rong Chang
Diabetes ◽  
1988 ◽  
Vol 37 (9) ◽  
pp. 1247-1252 ◽  
Author(s):  
J. A. Van der Vliet ◽  
X. Navarro ◽  
W. R. Kennedy ◽  
F. C. Goetz ◽  
J. J. Barbosa ◽  
...  

Diabetes ◽  
1988 ◽  
Vol 37 (9) ◽  
pp. 1247-1252 ◽  
Author(s):  
J. A. Van Der Vliet ◽  
X. Navarro ◽  
W. R. Kennedy ◽  
F. C. Goetz ◽  
J. J. Barbosa ◽  
...  

2021 ◽  
Vol 46 (2) ◽  
pp. 245-249
Author(s):  
Monika Cahova ◽  
Martin Kveton ◽  
Vojtech Petr ◽  
David Funda ◽  
Helena Dankova ◽  
...  

<b><i>Background:</i></b> Preclinical studies suggested that pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) by ACE inhibitors (ACEis) or angiotensin II receptor blockers (ARBs) may increase local angiotensin-converting enzyme 2 (<i>ACE2</i>) expression. <b><i>Methods:</i></b> In this study, we evaluated the effect of ACEi or ARB treatment on expression of <i>ACE2</i>, <i>ACE</i>, and <i>AGTR1</i> in 3-month protocol kidney allograft biopsies of stable patients using RT-qPCR (<i>n</i> = 48). Protein ACE2 expression was assessed using immunohistochemistry from paraffin sections. <b><i>Results:</i></b> The therapy with RAAS blockers was not associated with increased <i>ACE2, ACE</i>, or <i>ATGR1</i> expression in kidney allografts and also ACE2 protein immunohistochemistry did not reveal differences among groups. <b><i>Conclusions:</i></b> ACEis or ARBs in kidney transplant recipients do not affect local ACE2 expression. This observation supports long-term RAAS treatment in kidney transplant recipients, despite acute complications such as COVID-19 where ACE2 serves as the entry protein for infection.


2018 ◽  
Vol 19 (5) ◽  
pp. 1444-1451 ◽  
Author(s):  
Hege K. Pihlstrøm ◽  
Geir Mjøen ◽  
Sören Mucha ◽  
Andre Franke ◽  
Alan Jardine ◽  
...  

2014 ◽  
Vol 97 (9) ◽  
pp. 925-933 ◽  
Author(s):  
Jeffrey J. Gaynor ◽  
Gaetano Ciancio ◽  
Giselle Guerra ◽  
Junichiro Sageshima ◽  
Lois Hanson ◽  
...  

Xenobiotica ◽  
2013 ◽  
Vol 43 (7) ◽  
pp. 641-649 ◽  
Author(s):  
Shripad D. Chitnis ◽  
Ken Ogasawara ◽  
Björn Schniedewind ◽  
Reginald Y. Gohh ◽  
Uwe Christians ◽  
...  

2012 ◽  
Vol 94 (10S) ◽  
pp. 362
Author(s):  
N. Goto ◽  
Y. Matsuda ◽  
M. Takada ◽  
T. Yamamoto ◽  
M. Tsujita ◽  
...  

2019 ◽  
Vol 103 (8) ◽  
pp. 1705-1713 ◽  
Author(s):  
Tracey Ying ◽  
Germaine Wong ◽  
Wai H. Lim ◽  
Philip Clayton ◽  
John Kanellis ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document