scholarly journals Autophagy Is a Component of Epithelial Cell Fate in Obstructive Uropathy

2010 ◽  
Vol 176 (4) ◽  
pp. 1767-1778 ◽  
Author(s):  
Ling Li ◽  
Diana Zepeda-Orozco ◽  
Rachel Black ◽  
Fangming Lin
Keyword(s):  
Epithelial Cell ◽  
Cell Fate ◽  
Obstructive Uropathy

scholarly journals Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling

2013 ◽  
Vol 378 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Changgong Li ◽  
Aimin Li ◽  
Yiming Xing ◽  
Min Li ◽  
Belinda Chan ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Fate ◽  
Tgf Beta ◽  
Pulmonary Epithelial Cell

scholarly journals Medial Edge Epithelial Cell Fate during Palatal Fusion

2000 ◽  
Vol 220 (2) ◽  
pp. 343-357 ◽  
Author(s):  
C. Martı́nez-Álvarez ◽  
C. Tudela ◽  
J. Pérez-Miguelsanz ◽  
S. O'Kane ◽  
J. Puerta ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Fate ◽  
Palatal Fusion ◽  
Medial Edge

p21WAF1 Control of Epithelial Cell Cycle and Cell Fate

2002 ◽  
Vol 13 (6) ◽  
pp. 453-464 ◽  
Author(s):  
Wendy C. Weinberg ◽  
Mitchell F. Denning
Keyword(s):  
Cell Cycle ◽  
Epithelial Cell ◽  
Cell Fate ◽  
Cell Biology ◽  
Kinase Inhibitor ◽  
Growth Arrest ◽  
Nuclear Antigen ◽  
Central Position ◽  
Cyclin Dependent Kinase ◽  
Cyclin Dependent Kinase Inhibitor

As a broad-acting cyclin-dependent kinase inhibitor, p21WAF1 occupies a central position in the cell cycle regulation of self-renewing tissues such as oral mucosa and skin. In addition to regulating normal cell cycle progression decisions, p21WAF1 integrates genotoxic insults into growth arrest and apoptotic signaling pathways that ultimately determine cell fate. As a result of its complex interactions with cell cycle machinery and response to mutagenic agents, p21WAF1 also has stage-specific roles in epithelial carcinogenesis. Finally, a view is emerging of p21WAF1 as not merely a cyclin-dependent kinase inhibitor, but also as a direct participant in regulating genes involved in growth arrest, senescence, and aging, thus providing an additional layer of control over matters of the cell cycle. This review discusses these various roles played by p21WAF1 in cell cycle control, and attempts to relate these to epithelial cell biology, with special emphasis on keratinocytes. (Abbreviations used include the following: Brdu, 5-Bromo-2-deoxyuridine; cdk, cyclin-dependent kinase; EGF, epidermal growth factor; KIP, kinase inhibitor protein; PCNA, proliferating cell nuclear antigen; and TPA, 12-O-tetradecanoylphorbol-13-acetate.)

SMAD-Mediated TGFβ Family Signaling Regulates Epithelial Cell Fate in the Developing Vagina Through Expression of ΔNp63.

2012 ◽  
Vol 87 (Suppl_1) ◽  
pp. 147-147 ◽  
Author(s):  
Monica M. Laronda ◽  
Kenji Unno ◽  
Lindsey M. Butler ◽  
Vanida A. Serna ◽  
Alea A. Mills ◽  
...  
Keyword(s):  
Epithelial Cell ◽  
Cell Fate
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